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Gene Review

LDLR  -  low density lipoprotein receptor

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Disease relevance of ldlr


High impact information on ldlr


Biological context of ldlr


Anatomical context of ldlr


Associations of ldlr with chemical compounds

  • The major supply of cholesterol, the precursor for steroid and androgen biosynthesis, to ovarian cells is from circulating lipoproteins via membrane receptors from the low density lipoprotein receptor (LDL) superfamily [15].
  • In the current studies the sequence of amino acids at the NH2-terminus of the bovine adrenal LDL receptor was determined, and a synthetic peptide corresponding to amino acids 1-16 was prepared [12].
  • One of these sites, binding to which is inhibited by 30 mM EDTA, appears identical to the LDL receptor by ligand and immunoblotting and other characteristics [13].
  • The increased efficacy was blocked by heparin and was further increased by cell culture in 1% (vs. 10%) fetal bovine serum, suggesting that the effect may, at least in part, be mediated via the LDL receptor [16].
  • Cellular internalization of chol-modified oligonucleotide occurred at least partially through the LDL receptor; it was increased in mouse spleen cells by cell culture in lipoprotein-deficient medium and/or lovastatin, and it was decreased by culture in high serum medium [16].

Physical interactions of ldlr


Other interactions of ldlr


Analytical, diagnostic and therapeutic context of ldlr


  1. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Agnello, V., Abel, G., Elfahal, M., Knight, G.B., Zhang, Q.X. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. In Vitro Interaction between Hepatitis C Virus (HCV) Envelope Glycoprotein E2 and Serum Lipoproteins (LPs) Results in Enhanced Cellular Binding of Both HCV E2 and LPs. Wunschmann, S., Muller, H.M., Stipp, C.S., Hemler, M.E., Stapleton, J.T. J. Infect. Dis. (2006) [Pubmed]
  3. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Marchetti, M., Longhi, C., Conte, M.P., Pisani, S., Valenti, P., Seganti, L. Antiviral Res. (1996) [Pubmed]
  4. Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution. Anderson, R.G., Vasile, E., Mello, R.J., Brown, M.S., Goldstein, J.L. Cell (1978) [Pubmed]
  5. Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. Dehouck, B., Dehouck, M.P., Fruchart, J.C., Cecchelli, R. J. Cell Biol. (1994) [Pubmed]
  6. Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. Davies, P.F., Truskey, G.A., Warren, H.B., O'Connor, S.E., Eisenhaure, B.H. J. Cell Biol. (1985) [Pubmed]
  7. cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA. Russell, D.W., Yamamoto, T., Schneider, W.J., Slaughter, C.J., Brown, M.S., Goldstein, J.L. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  8. Molecular cloning of bovine LDL receptor cDNAs. Russell, D.W., Yamamoto, T. Meth. Enzymol. (1986) [Pubmed]
  9. Identification of a point mutation in growth factor repeat C of the low density lipoprotein-receptor gene in a patient with homozygous familial hypercholesterolemia that affects ligand binding and intracellular movement of receptors. Soutar, A.K., Knight, B.L., Patel, D.D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. Flow-related responses of intracellular inositol phosphate levels in cultured aortic endothelial cells. Prasad, A.R., Logan, S.A., Nerem, R.M., Schwartz, C.J., Sprague, E.A. Circ. Res. (1993) [Pubmed]
  11. Expression of mRNA of lipoprotein receptor related protein 8, low density lipoprotein receptor, and very low density lipoprotein receptor in bovine ovarian cells during follicular development and corpus luteum formation and regression. Argov, N., Sklan, D. Mol. Reprod. Dev. (2004) [Pubmed]
  12. Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. Schneider, W.J., Slaughter, C.J., Goldstein, J.L., Anderson, R.G., Capra, J.D., Brown, M.S. J. Cell Biol. (1983) [Pubmed]
  13. Membrane binding sites for plasma lipoproteins on endosomes from rat liver. Jaeckle, S., Brady, S.E., Havel, R.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  14. mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits. Hofmann, S.L., Russell, D.W., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  15. Lipid transport in the developing bovine follicle: messenger RNA expression increases for selective uptake receptors and decreases for endocytosis receptors. Argov, N., Moallem, U., Sklan, D. Biol. Reprod. (2004) [Pubmed]
  16. Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy. Krieg, A.M., Tonkinson, J., Matson, S., Zhao, Q., Saxon, M., Zhang, L.M., Bhanja, U., Yakubov, L., Stein, C.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  17. Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. Orr, A.W., Elzie, C.A., Kucik, D.F., Murphy-Ullrich, J.E. J. Cell. Sci. (2003) [Pubmed]
  18. Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG. Ji, Z.S., Mahley, R.W. Arterioscler. Thromb. (1994) [Pubmed]
  19. Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor. Jackman, R.W., Beeler, D.L., VanDeWater, L., Rosenberg, R.D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  20. Transcytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor. Obunike, J.C., Lutz, E.P., Li, Z., Paka, L., Katopodis, T., Strickland, D.K., Kozarsky, K.F., Pillarisetti, S., Goldberg, I.J. J. Biol. Chem. (2001) [Pubmed]
  21. AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. Conner, S.D., Schröter, T., Schmid, S.L. Traffic (2003) [Pubmed]
  22. Ovarian follicular steroidogenic acute regulatory protein, low-density lipoprotein receptor, and cytochrome P450 side-chain cleavage messenger ribonucleic acids in cattle undergoing superovulation. Soumano, K., Price, C.A. Biol. Reprod. (1997) [Pubmed]
  23. Vesicle-reconstituted low density lipoprotein receptor. Visualization by cryoelectron microscopy. Jeon, H., Shipley, G.G. J. Biol. Chem. (2000) [Pubmed]
  24. Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex. Schneider, W.J., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (1980) [Pubmed]
  25. Detection and quantitation of low density lipoprotein (LDL) receptors in human liver by ligand blotting, immunoblotting, and radioimmunoassay. LDL receptor protein content is correlated with plasma LDL cholesterol concentration. Soutar, A.K., Harders-Spengel, K., Wade, D.P., Knight, B.L. J. Biol. Chem. (1986) [Pubmed]
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