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MeSH Review

Genes, T-Cell Receptor beta

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High impact information on Genes, T-Cell Receptor beta

  • Accordingly, treatment of Ebeta-deleted thymocytes with the histone deacetylase inhibitor trichostatin A relieved the block in TCR-beta gene expression and promoted recombination within the Dbeta-Jbeta loci [1].
  • Analysis of the resulting CD4+/CD8+ thymocytes revealed no surface expression of the TCR/CD3 complex and no V-D-J rearrangement of the TCR-beta gene locus [2].
  • CD3 epsilon and CD3 zeta were expressed intracellularly 2 and 1 d, respectively, before intracellular expression of the TCR-beta chain, potentially allowing immediate surface expression of an immature TCR-beta-CD3 complex as soon as functional rearrangement of a TCR-beta gene locus has been accomplished [3].
  • Here, we demonstrate that this is not because of promoter or cell type but instead is directed by regulatory sequences within the rearranging VDJ exon and immediately flanking intron sequences of a Vbeta8.1 TCR-beta gene [4].
  • CHX also induces full length TCR-beta transcripts greater than 90-fold while TCR-beta gene transcription increases only 2- to 4-fold [5].

Biological context of Genes, T-Cell Receptor beta

  • Together these data suggest that the p70 autoantigen binds a critical motif in the beta enhancer and probably regulates TCR beta gene expression [6].
  • The expression of TRG gamma mRNA (transcripts of 1.6 kilobases [kb]) was highly variable from case to case and did not correlate with the stage of differentiation of the malignant cells, the expression of the molecules CD4 and CD8, the expression and size of the transcripts of the TCR beta genes, and the transcription of TCR alpha genes [7].
  • These results represent a previously unreported disease association and suggest that there may be some form of epistatic interaction between the CF gene and the TCR beta genes such that the double heterozygote is immunologically advantaged [8].
  • LD1 cells have deleted the TCR delta locus, have rearrangements at the TCR gamma gene cluster (i.e. a V gamma 1-J gamma 1-C gamma 1 and a V gamma 4.3-J gamma 4-C gamma 4) and have two rearrangements of the TCR beta gene cluster (i.e. a D beta 1-J beta 1 and V-D-J beta 2) [9].
  • Gene rearrangements were studied in 10 cases for IgH and TCR beta genes and in 5 cases for the TRG gene [10].

Anatomical context of Genes, T-Cell Receptor beta

  • CD3-epsilon-deficient thymocytes do rearrange their T cell receptor (TCR) beta gene segments and produce low levels of full-length TCR beta transcripts [11].
  • Southern blot analysis of total PBL gamma cell lines and clones indicated that this major circulating subset of TCR gamma cells retained a TCR beta gene in germline configuration and preferentially expressed a single V gamma gene, V gamma 5 for patient 1 and V gamma 9 for patient 2 [12].
  • The results presented here suggest that thymocytes may regulate GKLF transcriptionally in the cortical epithelium at the developmental check-point controlled by TCR beta gene rearrangement [13].
  • One case of B-cell leukaemia showed a rearrangement of both TCR beta genes and JH genes [14].
  • METHODS: The complementarity determining region 3 (CDR3) of the TCR beta gene with 24 variable regions was amplified in peripheral blood mononuclear cells drawn from one cGVHD patient after allogenic bone marrow transplantation (allo-BMT) 35, 39, 43 or 45 months respectively, using RT-PCR, to observe the expression of TCR V beta repertoire T cells [15].

Associations of Genes, T-Cell Receptor beta with chemical compounds

  • The 1.6-kb TCR-alpha and the 1.0-kb D beta J beta C beta TCR-beta gene transcripts were fully induced in the presence of cycloheximide, whereas the 1.3-kb V beta D beta J beta C beta transcript was only partly induced in the presence of cycloheximide [16].
  • The C gamma 1 gene segment, just like the TcR alpha and TcR beta gene segments, contains a cysteine codon in its second exon [17].
  • Thirty-five TCCs specific for PPD or TT and restricted by HLA-Dw4 and/or -Dw14.1 were selected for TCR beta gene sequencing [18].
  • The mutation in TCR beta gene affected the frequency of nucleotide insertions at the V delta-D delta signal joints and inhibited the formation of replacement joint [19].

Gene context of Genes, T-Cell Receptor beta

  • All samples expressed CD5, CD19 and CD20 and six patients had rearrangements of both immunoglobulin and TcR beta genes [20].
  • These observations suggest that the coordinate expressions of CD2 and TCR-beta genes share common regulatory mechanisms involving factors regulating chromatin structure and accessibility [21].
  • Moreover, the expression of the TCR beta gene was suppressed by IFN-beta under Con A stimulation, suggesting that IFN-beta might work as a negative regulator in immune recognition by activated T cells [22].
  • Survival of pAML patients with TcR-beta gene rearrangements was longer and survival of pAML patients with IL-3 or GM-CSF gene rearrangement was shorter than in patients without those rearrangements [23].
  • High overall diversity in the TCR alpha and TCR beta genes used for recognition of this self-Ag, MBP, was observed [24].


  1. Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination. Mathieu, N., Hempel, W.M., Spicuglia, S., Verthuy, C., Ferrier, P. J. Exp. Med. (2000) [Pubmed]
  2. Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice. Zúñiga-Pflücker, J.C., Jiang, D., Schwartzberg, P.L., Lenardo, M.J. J. Exp. Med. (1994) [Pubmed]
  3. Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes. Levelt, C.N., Carsetti, R., Eichmann, K. J. Exp. Med. (1993) [Pubmed]
  4. T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. Gudikote, J.P., Wilkinson, M.F. EMBO J. (2002) [Pubmed]
  5. Induction of T-cell receptor-alpha and -beta mRNA in SL12 cells can occur by transcriptional and post-transcriptional mechanisms. Wilkinson, M.F., MacLeod, C.L. EMBO J. (1988) [Pubmed]
  6. p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene. Messier, H., Fuller, T., Mangal, S., Brickner, H., Igarashi, S., Gaikwad, J., Fotedar, R., Fotedar, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. T cell rearranging gene gamma: diversity and mRNA expression in fresh cells from T cell acute lymphoblastic leukemia. Le Paslier, D., Chen, Z., Loiseau, P., Cohen, D., Sigaux, F. Blood (1987) [Pubmed]
  8. T cell receptor beta chain polymorphisms are associated with cystic fibrosis. McMillan, S.A., Hill, A.J., Graham, C.A., Nevin, N.C., Fay, A.C. J. Med. Genet. (1989) [Pubmed]
  9. LD1: a CD4-CD8- TCR alpha beta/CD3+ peripheral T cell line with helper function for B lymphocytes. Pelkonen, J., Palacios, R. Int. Immunol. (1990) [Pubmed]
  10. Lack of TdT and immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease. Villa, A., Cairo, G., Pozzi, M.R., Schiaffonati, L., Bardella, L., Lucchini, R., Delia, D., Besana, C., Biunno, I., Vezzoni, P. Int. J. Biol. Markers (1987) [Pubmed]
  11. Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. Malissen, M., Gillet, A., Ardouin, L., Bouvier, G., Trucy, J., Ferrier, P., Vivier, E., Malissen, B. EMBO J. (1995) [Pubmed]
  12. Prominent expansion of circulating lymphocytes bearing gamma T-cell receptors, with preferential expression of variable gamma genes after allogeneic bone marrow transplantation. Vilmer, E., Triebel, F., David, V., Rabian, C., Schumpp, M., Leca, G., Degos, L., Hercend, T., Sigaux, F., Bensussan, A. Blood (1988) [Pubmed]
  13. GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk. Panigada, M., Porcellini, S., Sutti, F., Doneda, L., Pozzoli, O., Consalez, G.G., Guttinger, M., Grassi, F. Mech. Dev. (1999) [Pubmed]
  14. Rearrangements of T-cell receptor beta-chain genes in human leukaemias. Kumar, S., Lavin, M.F., Smith, P.J., Pemble, L., Collins, R.J., Prentice, R.L. Mol. Immunol. (1986) [Pubmed]
  15. Stable clonal expansion of the T-cell receptor V beta 6, V beta 17 and V beta 19 T cells in a cGVHD case using genescan analysis. Li, Y., Du, X., Xu, M., Zhang, T., Yang, L., Chen, S. Chin. Med. J. (2001) [Pubmed]
  16. Transcription of T cell antigen receptor genes is induced by protein kinase C activation. Lindsten, T., June, C.H., Thompson, C.B. J. Immunol. (1988) [Pubmed]
  17. Two types of gamma T cell receptors expressed by T cell acute lymphoblastic leukemias. Van Dongen, J.J., Wolvers-Tettero, I.L., Seidman, J.G., Ang, S.L., Van de Griend, R.J., De Vries, E.F., Borst, J. Eur. J. Immunol. (1987) [Pubmed]
  18. T-cell receptor beta usage by 35 different antigen-specific T-cell clones restricted by HLA-Dw4 or -Dw14.1. Hansen, T., Qvigstad, E., Lundin, K.E., Thorsby, E. Hum. Immunol. (1992) [Pubmed]
  19. TCR delta gene rearrangements revealed by fine structure of the recombination junction in mice. Kanari, Y., Muto, M., Yamagishi, H. Microbiol. Immunol. (2003) [Pubmed]
  20. T-cell receptor beta gene rearrangements in leukaemic B-cells from patients with chronic lymphocytic leukaemia: association with chromosome 6 deletions. Merup, M., Juliusson, G., Hammarström, L., Smith, C.I., Gahrton, G. Br. J. Haematol. (1994) [Pubmed]
  21. Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene transcription. Kamoun, M., Woods, J.S., Sano, N., Makni, H., Smith, R., de Lau, W.B., van Oers, A., Wotton, D., Owen, M.J., Hashimoto, Y., Clevers, H.C. J. Immunol. (1995) [Pubmed]
  22. Suppressive effects of mouse interferon-beta on gene expression occurring in concanavalin A-stimulated mouse spleen cells. Watanabe, Y., Kawade, Y. Immunology (1988) [Pubmed]
  23. Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia. Schmetzer, H.M., Braun, S., Wiesner, D., Duell, T., Gerhartz, H.H., Mittermueller, J. Acta Haematol. (2000) [Pubmed]
  24. TCR alpha beta gene usage for myelin basic protein recognition in healthy monozygous twins. Shanmugam, A., Copie-Bergman, C., Falissard, B., Delrieu, O., Jais, J.P., Rebibo, D., Bach, J.F., Tournier-Lasserve, E. J. Immunol. (1996) [Pubmed]
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