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MeSH Review

Genes, T-Cell Receptor gamma

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Disease relevance of Genes, T-Cell Receptor gamma


High impact information on Genes, T-Cell Receptor gamma

  • Several recent studies have identified a distinct subset of CD3(T3)+CD4-CD8-T lymphocytes that express a CD3-associated heterodimer made up of the protein encoded by the T-cell receptor (TCR) gamma-gene and a second glycoprotein termed TCR delta (refs 1-4) [3].
  • Evidence indicates that this biased developmental potential is not a result of enhanced TCR-gamma gene rearrangement/expression in IL-7R(+) pro-T cells [4].
  • The expression of the murine TCR-gamma genes was examined in a series of IL-3-dependent and growth factor-independent cell lines [5].
  • TCR gamma repertoire diversification was initiated on embryonic day 10 by an apparently random pattern of V-J gamma recombination, nuclease activity, and P-and N-nucleotide additions to generate a diverse repertoire of avian TCR gamma genes early in ontogeny [6].
  • Induction of myeloid differentiation in these cells clones down expression and/or transcriptional accessibility of the immunoglobulin heavy-chain and TCR gamma genes [7].

Biological context of Genes, T-Cell Receptor gamma

  • CONCLUSION: Inconclusive histology is probably a heterogeneous group in which CD7 counts and TCR gamma gene rearrangement studies might help to differentiate the MF cases from the benign cases [8].
  • Molecular biology studies of immunomagnetically fractionated cells using a T gamma 9 TCR gamma gene primer further revealed that the CD4+ and CD8+ components were both clonal but showed different patterns of rearrangement [9].
  • T-cell receptor (TCR) gene analysis was performed on blood and tissue samples using polymerase chain reaction/single-strand conformational polymorphism analysis of the TCR-gamma gene using consensus primers [10].
  • T cell receptor gamma (TCR-gamma) and immunoglobulin heavy chain (IgH) gene rearrangements were assayed using our standard clinical polymerase chain reaction procedures targeting each of the four functional variable (V) families and the three joining (J) families of the TCR-gamma gene, and framework III of the IgH gene, respectively [11].
  • AD genes were mapped near the FC epsilon RI beta gene (around D11S1314 locus) on chromosome 11, the IL4 gene cluster on chromosome 5 and the TCR gamma gene on chromosome 7 [12].

Anatomical context of Genes, T-Cell Receptor gamma


Associations of Genes, T-Cell Receptor gamma with chemical compounds

  • Mutant T-lymphocytes with rearranged TCR gamma genes containing the same V and J subgroups were analyzed using PCR-based denaturing polyacrylamide gel electrophoresis [16].
  • The data presented here suggest that TCR gamma gene rearrangement in adult pre-T cells is regulated by IL-7, but that the TCR beta locus requires additional or alternative signals for the induction of complete rearrangement [17].
  • The MNNG-exposed Bloom syndrome (BS) B-lymphoblastoid cell population (BS-MNNG), when analyzed for aberrant genetic variations, showed an illegitimate rearrangement at the TCR-gamma gene and hypermethylation at the c-myb protooncogene [18].

Gene context of Genes, T-Cell Receptor gamma

  • The results demonstrate that IL-7R-mediated signals are necessary for the normal expression of rearranged TCR-gamma genes [19].
  • To investigate this observation in general terms we examined various IL-3 dependent cell lines for TCR gamma gene expression [15].
  • 32D cells transfected with the IL-2 beta chain receptor became responsive to IL-2 as a growth factor and induced TCR gamma gene expression [15].
  • Specificity for detection of an EITCL using immunohistology was 77% for CD8 and for TCR-beta staining, and 100% for detection of a clonal TCR-gamma gene rearrangement [20].
  • We postulate that there is an evolutionary chromosomal breakpoint between the bg gene and the TCR-gamma gene [21].


  1. Hepatosplenic gamma/delta T-cell lymphoma in immunocompromised patients. Report of two cases and review of literature. Khan, W.A., Yu, L., Eisenbrey, A.B., Crisan, D., al Saadi, A., Davis, B.H., Hankin, R.C., Mattson, J.C. Am. J. Clin. Pathol. (2001) [Pubmed]
  2. Lineage switch in childhood leukemia with monosomy 7 and reverse of lineage switch in severe combined immunodeficient mice. Fujisaki, H., Hara, J., Takai, K., Nakanishi, K., Matsuda, Y., Ohta, H., Osugi, Y., Tokimasa, S., Taniike, M., Hosoi, G., Sako, M., Okada, S. Exp. Hematol. (1999) [Pubmed]
  3. Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes. Matis, L.A., Cron, R., Bluestone, J.A. Nature (1987) [Pubmed]
  4. Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling. Kang, J., Volkmann, A., Raulet, D.H. J. Exp. Med. (2001) [Pubmed]
  5. Interleukin 3 (IL-3) induces transcription from nonrearranged T cell receptor gamma loci in IL-3-dependent cell lines. Weinstein, Y., Morishita, K., Cleveland, J.L., Ihle, J.N. J. Exp. Med. (1989) [Pubmed]
  6. Characterization of avian T-cell receptor gamma genes. Six, A., Rast, J.P., McCormack, W.T., Dunon, D., Courtois, D., Li, Y., Chen, C.H., Cooper, M.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNase I-hypersensitive in hemopoietic progenitor cells. Ford, A.M., Bennett, C.A., Healy, L.E., Navarro, E., Spooncer, E., Greaves, M.F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Immunophenotyping and T-cell receptor gamma gene rearrangement analysis as an adjunct to the histopathologic diagnosis of mycosis fungoides. Bergman, R., Faclieru, D., Sahar, D., Sander, C.A., Kerner, H., Ben-Aryeh, Y., Manov, L., Hertz, E., Sabo, E., Friedman-Birnbaum, R. J. Am. Acad. Dermatol. (1998) [Pubmed]
  9. A biclonal large granular lymphocyte (LGL)/NK-associated (NKa) disorder of CD4+ and CD8+ lymphocyte subpopulations characterized by the simultaneous presence of distinct TCR rearrangements. Richards, S.J., Short, M., Steed, A.J., Scott, C.S. Br. J. Haematol. (1994) [Pubmed]
  10. Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Hoque, S.R., Child, F.J., Whittaker, S.J., Ferreira, S., Orchard, G., Jenner, K., Spittle, M., Russell-Jones, R. Br. J. Dermatol. (2003) [Pubmed]
  11. Lymphoid tissues from patients with infectious mononucleosis lack monoclonal B and T cells. Plumbley, J.A., Fan, H., Eagan, P.A., Ehsan, A., Schnitzer, B., Gulley, M.L. The Journal of molecular diagnostics : JMD. (2002) [Pubmed]
  12. Genetic association analysis using microsatellite markers in atopic dermatitis. Iizuka, M., Katsuyama, Y., Mabuchi, T., Umezawa, Y., Matsuyama, T., Ozawa, A., Kawada, H., Inoko, H., Morita, E., Ota, M. Tokai J. Exp. Clin. Med. (2002) [Pubmed]
  13. Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. Durum, S.K., Candèias, S., Nakajima, H., Leonard, W.J., Baird, A.M., Berg, L.J., Muegge, K. J. Exp. Med. (1998) [Pubmed]
  14. Ontogeny of murine T cells: thymus-regulated development of T cell receptor-bearing cells derived from embryonic yolk sac. Liu, C.P., Auerbach, R. Eur. J. Immunol. (1991) [Pubmed]
  15. Regulation of T cell receptor gamma gene expression by cytokines in murine hematopoietic cells. Weinstein, Y., Askew, D.S., Miura, O., Cleveland, J.L., Ihle, J.N. Eur. Cytokine Netw. (1995) [Pubmed]
  16. Multiplex polymerase chain reaction-based analysis of T-cell receptor gamma gene rearrangements for the determination of T-lymphocyte clonality. Ma, H., Smith, D.H., Hsie, A.W., Ward, J.B. Environ. Mol. Mutagen. (2000) [Pubmed]
  17. Interleukin 7 induces TCR gene rearrangement in adult marrow-resident murine precursor T cells. Soloff, R.S., Wang, T.G., Dempsey, D., Jennings, S.R., Wolcott, R.M., Chervenak, R. Mol. Immunol. (1997) [Pubmed]
  18. T-cell receptor-gamma rearrangement and c-myb methylation in MNNG-exposed Bloom syndrome B-lymphoblastoid cells. Bhalla, A., Sachdeva, G., Bamezai, R. Cancer Lett. (1998) [Pubmed]
  19. Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes. Kang, J., Coles, M., Raulet, D.H. J. Exp. Med. (1999) [Pubmed]
  20. Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue. Daum, S., Weiss, D., Hummel, M., Ullrich, R., Heise, W., Stein, H., Riecken, E.O., Foss, H.D. Gut (2001) [Pubmed]
  21. Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor gamma chain in mouse and man. Holcombe, R.F., Strauss, W., Owen, F.L., Boxer, L.A., Warren, R.W., Conley, M.E., Ferrara, J., Leavitt, R.Y., Fauci, A.S., Taylor, B.A. Genomics (1987) [Pubmed]
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