The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Multiple Birth Offspring

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Multiple Birth Offspring


High impact information on Multiple Birth Offspring

  • CONCLUSIONS: Based on these data, the risk of multiple births from IVF varies by maternal age and number of embryos transferred [4].
  • Results of some studies, however, suggest an increase in multiple births associated with use of vitamin supplements that contain folic acid during pregnancy [1].
  • Townes-Brocks syndrome (TBS, OMIM #107480) is an autosomal dominant disorder that causes multiple birth defects including renal, ear, anal and limb malformations [5].
  • Further, the reduction in risk seemed to diminish with increasing parity, and among women with 4 or more full-term pregnancies, ever having had a multiple birth was associated with an elevated risk (IRR = 1.48, 95% CI = 0.97-2.25) [6].
  • After multiple birth, newborn plasma SS, but not plasma CCK, was significantly lower than after single birth (9.1 +/- 7.7 versus 16.9 +/- 12.7 pmol/L) [7].

Biological context of Multiple Birth Offspring

  • OBJECTIVE: To examine associations between the number of embryos transferred during IVF and live-birth and multiple-birth rates stratified by maternal age and whether extra embryos were available (ie, extra embryos cryopreserved) [4].
  • The probability of multiple births when multiple gestational sacs or viable embryos are diagnosed at first trimester ultrasound [8].
  • In the context of the day-to-day variability in diabetes "control" of the poorly regulated mother, and the relatively longer duration of organogenesis, these multifactorial possibilities may account for the multiple birth defects that can occur in individual offspring, and the seemingly non-specific pattern of diabetic embryopathy [9].
  • Other factors associated with earlier administration of the initial surfactant dose were gestational age, lower 1-minute Apgar score, cesarean delivery, antenatal steroid treatment, multiple birth, and small size for gestational age [10].
  • PURPOSE: The concordance of strabismic phenotypes was examined in monozygotic versus multizygotic twins and other multiple births to study the role of genetic background in different types of commitant strabismus [11].

Anatomical context of Multiple Birth Offspring


Associations of Multiple Birth Offspring with chemical compounds

  • The multiple birth rate for clomiphene-HMG (7/21) equalled that for HMG alone (3/12) and HMG and clomiphene together (3/8) [13].
  • Therefore, daily estrogen determinations from the 1st day of treatment are mandatory in order to avoid hyperstimulation and/or multiple births [14].
  • The mothers with the dizygotic multiple births were on moderate to elevated levels of heroin or methadone at the time of conception [15].
  • Comparison with the most recent published national data relating to birthweight specific survival of very low birthweight singleton and multiple births suggests that the downward trend of mortality is continuing, at least in this Region [16].
  • The effectiveness of dexamethasone was analyzed with respect to the condition of the infant at delivery, the mode of delivery, and multiple births [17].

Gene context of Multiple Birth Offspring

  • These results have clinical implications in managing the entire multiple birth family where one twin has ADHD, and also has implications for genetic analysis in modeling the relationship of ADHD to internalizing disorders [18].
  • PATIENTS AND METHODS: Cord blood samples were obtained from preterm singletons (N=11), preterm multiple births (N=10), full-term infants (N=24), as well as adults (N=22), for comparison [12].
  • This study evaluated genetic and developmental contributions to epilepsy, using data on epilepsy and multiple births in the sibships of 1981 probands with epilepsy [19].
  • Since these PRL surges may be regulated in part by endogenous opioids and opioid sensitivity declines as a function of multiple births, we decided to investigate the possibility that prior parity might affect the post-coital diurnal and nocturnal PRL surges, reducing their magnitude and/or occurrence [20].
  • The immediate, or "stat", autopsy is a diagnostic modality involving the use of multiple procedures for the rapid diagnosis of perinatal infection which may be lifesaving in the setting of multiple birth neonates [21].

Analytical, diagnostic and therapeutic context of Multiple Birth Offspring


  1. Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study. Li, Z., Gindler, J., Wang, H., Berry, R.J., Li, S., Correa, A., Zheng, J.C., Erickson, J.D., Wang, Y. Lancet (2003) [Pubmed]
  2. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Bailey, L.B., Berry, R.J. Am. J. Clin. Nutr. (2005) [Pubmed]
  3. A rapid evolution mechanism may contribute to changes in sex ratio, multiple birth incidence, frequency of auto-immune disease and frequency of birth defects in Clomid conceptions. Fischer, K. Med. Hypotheses (1990) [Pubmed]
  4. Live-birth rates and multiple-birth risk using in vitro fertilization. Schieve, L.A., Peterson, H.B., Meikle, S.F., Jeng, G., Danel, I., Burnett, N.M., Wilcox, L.S. JAMA (1999) [Pubmed]
  5. Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Kiefer, S.M., Ohlemiller, K.K., Yang, J., McDill, B.W., Kohlhase, J., Rauchman, M. Hum. Mol. Genet. (2003) [Pubmed]
  6. Multiple births, sex of children and subsequent breast-cancer risk for the mothers: a prospective study in Norway. Albrektsen, G., Heuch, I., Kvåle, G. Int. J. Cancer (1995) [Pubmed]
  7. Plasma somatostatin and cholecystokinin levels in preterm infants and their mothers at birth. Törnhage, C.J., Serenius, F., Uvnäs-Moberg, K., Lindberg, T. Pediatr. Res. (1995) [Pubmed]
  8. The probability of multiple births when multiple gestational sacs or viable embryos are diagnosed at first trimester ultrasound. Dickey, R.P., Olar, T.T., Curole, D.N., Taylor, S.N., Rye, P.H., Matulich, E.M. Hum. Reprod. (1990) [Pubmed]
  9. Diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models. Freinkel, N. Horm. Metab. Res. (1988) [Pubmed]
  10. Timing of initial surfactant treatment for infants 23 to 29 weeks' gestation: is routine practice evidence based? Horbar, J.D., Carpenter, J.H., Buzas, J., Soll, R.F., Suresh, G., Bracken, M.B., Leviton, L.C., Plsek, P.E., Sinclair, J.C. Pediatrics (2004) [Pubmed]
  11. Concordance of strabismic phenotypes in monozygotic versus multizygotic twins and other multiple births. Matsuo, T., Hayashi, M., Fujiwara, H., Yamane, T., Ohtsuki, H. Jpn. J. Ophthalmol. (2002) [Pubmed]
  12. Cord blood red cell osmotic fragility: a comparison between preterm and full-term newborn infants. Bautista, M.L., Altaf, W., Lall, R., Wapnir, R.A. Early Hum. Dev. (2003) [Pubmed]
  13. Sequential clomiphene citrate and human menopausal gonadotrophin for ovulation induction: comparison to clomiphene citrate alone and human menopausal gonadotrophin alone. Dickey, R.P., Olar, T.T., Taylor, S.N., Curole, D.N., Rye, P.H. Hum. Reprod. (1993) [Pubmed]
  14. The use of human gonadotropins for the induction of ovulation in women with polycystic ovarian disease. Wang, C.F., Gemzell, C. Fertil. Steril. (1980) [Pubmed]
  15. Multiple births in drug-addicted women. Rementeria, J.L., Janakammal, S., Hollander, M. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  16. Monitoring fetal and infant survival using regional birth notification data in north east London. Hilder, L., Alberman, E. Journal of epidemiology and community health. (1998) [Pubmed]
  17. Dexamethasone for prevention of respiratory distress syndrome: multiple perinatal factors. Caspi, E., Schreyer, P., Weinraub, Z., Lifshitz, Y., Goldberg, M. Obstetrics and gynecology. (1981) [Pubmed]
  18. Having a co-twin with attention-deficit hyperactivity disorder. McDougall, M.R., Hay, D.A., Bennett, K.S. Twin research and human genetics : the official journal of the International Society for Twin Studies. (2006) [Pubmed]
  19. Genetic and developmental influences on susceptibility to epilepsy: evidence from twins. Ottman, R. Paediatric and perinatal epidemiology. (1992) [Pubmed]
  20. Prior parity reduces post-coital diurnal and nocturnal prolactin surges in rats. Bridges, R.S., Felicio, L.F., Pellerin, L.J., Stuer, A.M., Mann, P.E. Life Sci. (1993) [Pubmed]
  21. Disseminated herpes simplex infection in a twin: the role of the "stat" autopsy in immediate therapeutic intervention for survival of multiple birth neonates. Schwartz, D.A., Bueso-Ramos, C., Siegel, R. Journal of perinatal medicine. (1992) [Pubmed]
  22. Risk of multiple birth associated with in vitro fertilization using donor eggs. Reynolds, M.A., Schieve, L.A., Jeng, G., Peterson, H.B., Wilcox, L.S. Am. J. Epidemiol. (2001) [Pubmed]
  23. Safety issues in assisted reproduction technology: the children of assisted reproduction confront the responsible conduct of assisted reproductive technologies. Lambert, R.D. Hum. Reprod. (2002) [Pubmed]
  24. Improved pregnancy rate with monitoring of gonadotropin therapy by three modalities. March, C.M. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  25. Hospital care utilization of infants born after IVF. Ericson, A., Nygren, K.G., Olausson, P.O., Källén, B. Hum. Reprod. (2002) [Pubmed]
WikiGenes - Universities