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Chemical Compound Review

Clomid     2-[4-(2-chloro-1,2-diphenyl...

Synonyms: Chloramiphene, DSSTox_CID_337, CAS-50-41-9, HMS3259B09, NC00631, ...
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Disease relevance of Clomid


High impact information on Clomid


Chemical compound and disease context of Clomid


Biological context of Clomid

  • It also may be effective in inducing ovulation in some amenorrheic patients refractory to Clomid treatment [12].
  • Clomid therapy can lengthen the luteal phase in patients with luteal temperature elevation of 10 days or less [13].
  • It has been concluded that the differentiation of the estradiol binding sites (specific or unspecific) with the elevated temperature effect or the additon of Clomid may be helpful only as a qualitative test [14].
  • Clostilbegyt was used from the 4th day of the menstruation in a five day period [15].
  • This is to our knowledge, the first document of a commercially important male teleostean fish Clarias batrachus with high nutritive value being made to spermiate in the laboratory 4 months ahead of natural schedule, using a chemical inductor 'Clomid' [16].

Anatomical context of Clomid


Associations of Clomid with other chemical compounds

  • Mid-luteal phase serum progesterone, cortisol, and corticosteroid-binding globulin concentrations were measured in 46 conception cycles and in 19 ovulatory, non-conception cycles in patients with spontaneous ovulation and following ovulation induction with clomiphene citrate (Clomid) or human menopausal gonadotropin [20].
  • Prednisolone supplementation to Clomid and/or gonadotrophin stimulation for in-vitro fertilization--a prospective randomized trial [21].
  • However, whereas Clomid produced a decrease in the LH response to LH-releasing hormone (LHRH), no such effect was seen after the administration of tamoxifen [22].
  • Endometrial samples were obtained from 49 subfertility patients on clomiphene citrate (Clomid) therapy admitted to hospital for dye laparoscopy [23].
  • Hightened thyroidal activity and CR (conversion ratio of PB 131I in blood serum in relation to total serum 131I uptake) were noticed a week after clomid (150 microgram/fish/day) and sexovid (150 microgram/fish/day) treatment [24].

Gene context of Clomid

  • No cyclic variation was observed in AR binding sites of women on Clomid therapy [23].
  • It is concluded that a cyclic variation was observed in ER and PR binding sites in women on Clomid therapy [23].
  • Radiation-sensitive mutants, uvrA and recA, were more sensitive to Clomid than the parental wild-type strain [5].
  • It is concluded that a combined Clomid/HCG regimen can often be used as an effective alternative to bromocriptine therapy in the treatment of infertility associated with hyperprolactinemic amenorrhea [4].
  • The serum PRL levels were normal during the control cycle in five of the patients who ovulated with Clomid and high in four patients who failed to ovulate [25].

Analytical, diagnostic and therapeutic context of Clomid


  1. Clomid or nafoxidine administered to neonatal rats causes reproductive tract abnormalities. Clark, J.H., McCormack, S. Science (1977) [Pubmed]
  2. Restoration of plasma testosterone levels in uremic men with clomiphene citrate. Lim, V.S., Fang, V.S. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  3. Clomid in unexplained infertility. Check, J.H. Fertil. Steril. (1998) [Pubmed]
  4. Induction of ovulation in women with hyperprolactinemic amenorrhea using clomiphene and human chorionic gonadotropin of bromocriptine. Radwanska, E., McGarrigle, H.H., Little, V., Lawrence, D., Sarris, S., Swyer, G.I. Fertil. Steril. (1979) [Pubmed]
  5. An ovulation inducing agent containing clomiphene citrate causes DNA-strand breaks without SOS responses in Escherichia coli. Ohnishi, T., Ohashi, Y., Amano, I., Nozu, K. Mutat. Res. (1986) [Pubmed]
  6. Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers. McCormack, S., Clark, J.H. Science (1979) [Pubmed]
  7. Direct evidence of estrogen modulation of pituitary sensitivity to luteinizing hormone-releasing factor during the menstrual cycle. Wang, C.F., Yen, S.S. J. Clin. Invest. (1975) [Pubmed]
  8. Are laparoscopic ovarian diathermy and gonadotropin administration the only therapeutic second-steps in clomiphene-citrate resistant women with polycystic ovary syndrome? Palomba, S., Orio, F., Falbo, A., Russo, T., Lombardi, G., Zullo, F. Hum. Reprod. (2004) [Pubmed]
  9. Sex steroids in cervical mucus of spontaneous or induced ovulatory cycles. Adamopoulos, D.A., Kapolla, N., Abrahamian, A., Dessypris, A., Nicopoulou, S., Giannacodemos, G. Steroids (2000) [Pubmed]
  10. Clomid for unexplained infertility? Simple lie or complicated truth? Mersol-Barg, M.S., Dlugi, A.M. Fertil. Steril. (1994) [Pubmed]
  11. A neutrophilic drug reaction to Clomid. Coots, N.V., McCoy, C.E., Gehlbach, D.L., Becker, L.E. Cutis; cutaneous medicine for the practitioner. (1996) [Pubmed]
  12. Induction of an LH surge with estradiol benzoate. A clinical test of pituitary-hypothalamic axis competence. Weiss, G., Nachtigall, L.E., Ganguly, M. Obstetrics and gynecology. (1976) [Pubmed]
  13. Clomiphene citrate in the management of infertility associated with shortened luteal phases. Quagliarello, J., Weiss, G. Fertil. Steril. (1979) [Pubmed]
  14. Estimation of high affinity estradiol binding sites in the human breast cancer. Paszkoand, Z., Padzik, H. Arch. Geschwulstforsch. (1975) [Pubmed]
  15. Examination of the follicular maturation influencing effect of Clostilbegyt by endocrinous and electronic monitoring. Cseh, I., Perkedi, G., Drávucz, S., Gáti, I. Therapia Hungarica (English edition) (1991) [Pubmed]
  16. Induction of artificial spermiation in the fresh water Clarias batrachus (Linn.) by clomiphene citrate. Kumar, S. Exp. Clin. Endocrinol. (1985) [Pubmed]
  17. Alterations induced by clomiphene in the concentrations of oestrogen receptors in the uterus, pituitary gland and hypothalamus of female rats. Adashi, E.Y., Hsueh, A.J., Yen, S.S. J. Endocrinol. (1980) [Pubmed]
  18. Clomid effect on cervical mucus. Kokia, E. Fertil. Steril. (1991) [Pubmed]
  19. Relative effects of estradiol-17beta (E2), catecholestrogens and clomiphene citrate on in vitro oocyte maturation in the catfish Heteropneustes fossilis (Bloch) and E2 inhibition of 2-hydroxyestradiol-induced maturation. Mishra, A., Joy, K.P. Gen. Comp. Endocrinol. (2006) [Pubmed]
  20. Effect of clomiphene citrate on corticosteroid-binding globulin and serum progesterone levels during ovulation induction. Hammond, M.G., Radwanska, E., Talbert, L.M. Fertil. Steril. (1980) [Pubmed]
  21. Prednisolone supplementation to Clomid and/or gonadotrophin stimulation for in-vitro fertilization--a prospective randomized trial. Kemeter, P., Feichtinger, W. Hum. Reprod. (1986) [Pubmed]
  22. Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men. Vermeulen, A., Comhaire, F. Fertil. Steril. (1978) [Pubmed]
  23. Clomiphene citrate therapy and unexplained subfertility. Suri, N.K. East African medical journal. (1996) [Pubmed]
  24. Thyroid activity and TSH levels in pituitary gland and blood serum in response to clomid, sexovid and prostaglandins treatment in Heteropneustes fossilis (Bloch). Singh, A.K., Singh, T.P. Endokrinologie. (1977) [Pubmed]
  25. Effect of clomiphene citrate on serum prolactin in infertile women with ovarian dysfunction. Seki, K., Seki, M., Okumura, T., Huang, K. Am. J. Obstet. Gynecol. (1976) [Pubmed]
  26. The origin and distribution of cortical granules in human oocytes with reference to Golgi, nucleolar, and microfilament activity. Sathananthan, A.H., Ng, S.C., Chia, C.M., Law, H.Y., Edirisinghe, W.R., Ratnam, S.S. Ann. N. Y. Acad. Sci. (1985) [Pubmed]
  27. Comparative trial of clomiphene citrate/human menopausal gonadotropin and the contraceptive pill, followed by clomiphene citrate/human menopausal gonadotropin, in a gamete intrafallopian transfer program. Kruger, T.F., Fisher, A., Swart, Y., Van der Merwe, J.P., Smith, K. J. Assist. Reprod. Genet. (1993) [Pubmed]
  28. The effect of clomid induced superovulation on human follicular and luteal function for extracorporeal fertilization and embryo transfer. Kerin, J.F., Warnes, G.M., Quinn, P., Jeffrey, R., Godfrey, B., Broom, T.J., McEvoy, M., Kirby, C., Johnson, M., Cox, L.W. Clinical reproduction and fertility. (1983) [Pubmed]
  29. Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome. Qublan, H.S., Malkawi, H.Y. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. (2005) [Pubmed]
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