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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Receptor Cross-Talk

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Disease relevance of Receptor Cross-Talk


High impact information on Receptor Cross-Talk

  • These studies delineate a mechanism of Gq- and Gs-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+i) release as a result of interaction with calcyon [5].
  • The synergistic effects of highly expressed IL-6R alpha on IGF-I receptor-mediated signals provide a novel insight into the Jak-independent IL-6 signaling mechanism of receptor cross-talk in human myeloma cells [6].
  • Because SOCS protein expression is induced by many cytokines and has been reported to extinguish signaling from several hematopoietic cytokine receptors, these results identify a molecular mechanism responsible for cytokine receptor cross-talk [7].
  • These results identify a novel system of receptor cross-talk between CD40 and BCR and indicate that the effects of CD40 engagement on subsequent BCR stimulation spread beyond NF-kappaB to involve the MAPK pathway [8].
  • To identify a molecular basis for this receptor cross-talk, we examined ERK activation and NF-kappaB induction [9].

Biological context of Receptor Cross-Talk


Anatomical context of Receptor Cross-Talk


Associations of Receptor Cross-Talk with chemical compounds

  • Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk [15]?
  • Long-term depression (LTD) induction relies upon receptor cross-talk between group I and group II metabotropic glutamate receptors (mGluRs) in perirhinal cortex [16].
  • The reduction in ET-1-induced [Ca2+]i after NE/ISO treatment appears to be due to elevated cAMP levels via beta-receptor activation, suggesting the existence of receptor cross talk [17].
  • Furthermore, treatment of tissues with deoxy-PGE1 and the Ca(2+) ionophore A-23187 stimulated synergistic increases in R and cAMP, indicating that PGE2 triggers recovery of R via EP receptor cross talk mechanisms involving cAMP and intracellular Ca(2+) [18].
  • These novel results on the ErbB/retinoid receptor cross-talk may be useful for designing future anticancer combination regimens [19].

Gene context of Receptor Cross-Talk

  • Both events are regulated by TSHR via a multiplicity of signals, with the aid of and requirement for a multiplicity of hormones that regulate the TSHR via receptor cross-talk: insulin, IGF-I, adrenergic receptors, and purinergic receptors [20].
  • Gefitinib pretreatment blocked receptor cross-talk, reestablished corepressor complexes with tamoxifen-bound ER on target gene promoters, eliminated tamoxifen's agonist effects, and restored its antitumor activity both in vitro and in vivo in MCF-7/HER2-18 cells [21].
  • Moreover, the accentuated response to PAR-1 activation in PAR-2-deficient mice suggests a compensatory response and potential receptor cross-talk [22].
  • Reverse transcription-polymerase chain reaction analysis also demonstrated ErbB2 and ErbB3 expression in human bladder muscle tissue, suggesting the possibility of receptor cross-talk after ErbB1 activation [23].
  • Thus, for patients with MBC whose tumors co-express EGFR and HER2, gefitinib in combination with trastuzumab may prevent receptor cross-talk, improving the outcome of MBC [24].


  1. Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Lautrette, A., Li, S., Alili, R., Sunnarborg, S.W., Burtin, M., Lee, D.C., Friedlander, G., Terzi, F. Nat. Med. (2005) [Pubmed]
  2. Overexpression of estrogen receptor in HTB 96 human osteosarcoma cells results in estrogen-induced growth inhibition and receptor cross talk. Watts, C.K., King, R.J. J. Bone Miner. Res. (1994) [Pubmed]
  3. Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription. Jezova, M., Armando, I., Bregonzio, C., Yu, Z.X., Qian, S., Ferrans, V.J., Imboden, H., Saavedra, J.M. Endocrinology (2003) [Pubmed]
  4. Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. Peart, J.N., Gross, G.J. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  5. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. Lezcano, N., Mrzljak, L., Eubanks, S., Levenson, R., Goldman-Rakic, P., Bergson, C. Science (2000) [Pubmed]
  6. Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor alpha [corrected]. Abroun, S., Ishikawa, H., Tsuyama, N., Liu, S., Li, F.J., Otsuyama, K., Zheng, X., Obata, M., Kawano, M.M. Blood (2004) [Pubmed]
  7. Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. Wang, Q., Miyakawa, Y., Fox, N., Kaushansky, K. Blood (2000) [Pubmed]
  8. B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activation. Mizuno, T., Rothstein, T.L. J. Immunol. (2005) [Pubmed]
  9. B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent. Guo, B., Rothstein, T.L. J. Immunol. (2005) [Pubmed]
  10. Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis. Yosypiv, I.V., Schroeder, M., El-Dahr, S.S. J. Am. Soc. Nephrol. (2006) [Pubmed]
  11. Combination of 1alpha,25-dihydroxyvitamin D(3) with dexamethasone enhances cell cycle arrest and apoptosis: role of nuclear receptor cross-talk and Erk/Akt signaling. Bernardi, R.J., Trump, D.L., Yu, W.D., McGuire, T.F., Hershberger, P.A., Johnson, C.S. Clin. Cancer Res. (2001) [Pubmed]
  12. Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type-2 diabetes: studies in gonadectomized and sham-operated Zucker diabetic rats. Ajayi, A.A., Ogungbade, G.O., Okorodudu, A.O. Eur. J. Clin. Invest. (2004) [Pubmed]
  13. Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44. Rothman, B.L., Blue, M.L., Kelley, K.A., Wunderlich, D., Mierz, D.V., Aune, T.M. J. Immunol. (1991) [Pubmed]
  14. Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium. Arosio, B., Perlini, S., Calabresi, C., Tozzi, R., Palladini, G., Ferrari, A.U., Vergani, C., Annoni, G. Exp. Gerontol. (2003) [Pubmed]
  15. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk? Kearn, C.S., Blake-Palmer, K., Daniel, E., Mackie, K., Glass, M. Mol. Pharmacol. (2005) [Pubmed]
  16. Metabotropic glutamate receptor signalling in perirhinal cortical neurons. Harris, S.L., Cho, K., Bashir, Z.I., Molnar, E. Mol. Cell. Neurosci. (2004) [Pubmed]
  17. Cholinergic and adrenergic modulation of the Ca2+ response to endothelin-1 in human ciliary muscle cells. Prasanna, G., Dibas, A.I., Yorio, T. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  18. PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum. Blikslager, A.T., Pell, S.M., Young, K.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  19. An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells. Grunt, T.W., Puckmair, K., Tomek, K., Kainz, B., Gaiger, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  20. The thyrotropin receptor. Kohn, L.D., Shimura, H., Shimura, Y., Hidaka, A., Giuliani, C., Napolitano, G., Ohmori, M., Laglia, G., Saji, M. Vitam. Horm. (1995) [Pubmed]
  21. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. Shou, J., Massarweh, S., Osborne, C.K., Wakeling, A.E., Ali, S., Weiss, H., Schiff, R. J. Natl. Cancer Inst. (2004) [Pubmed]
  22. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. Damiano, B.P., Cheung, W.M., Santulli, R.J., Fung-Leung, W.P., Ngo, K., Ye, R.D., Darrow, A.L., Derian, C.K., de Garavilla, L., Andrade-Gordon, P. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  23. Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction. Borer, J.G., Park, J.M., Atala, A., Nguyen, H.T., Adam, R.M., Retik, A.B., Freeman, M.R. Lab. Invest. (1999) [Pubmed]
  24. Induction of remission in a patient with metastatic breast cancer refractory to trastuzumab and chemotherapy following treatment with gefitinib ('Iressa', ZD1839). Schneeweiss, A., Kolay, S., Aulmann, S., Von Minckwitz, G., Torode, J., Koehler, M., Bastert, G. Anticancer Drugs (2004) [Pubmed]
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