Gene Review:
F2rl1 - coagulation factor II (thrombin) receptor...
Mus musculus
Synonyms:
Coagulation factor II receptor-like 1, G-protein coupled receptor 11, Gpcr11, Gpr11, PAR-2, ...
Selemidis,
Tamiya,
Fujii,
Kanke,
Saito,
Masuko,
Helin,
Meek,
Santulli,
Dunning,
Ramage,
Kataoka,
Fung-Leung,
Takebe,
Takizawa,
Matsumoto,
Matsumoto,
Jiang,
Hattori,
Takizawa,
Saito,
Jeffrey,
Kawagoe,
Shimada,
Cheung,
Smith,
Cocks,
McLean,
Bacon,
Plevin,
McGarry,
Plevin,
Kanke,
Kuroda,
Hunter,
Kawagoe,
Ferrell,
Andrade-Gordon,
Hara,
Shichijo,
Cocks,
Kondo,
Moffatt,
Meek,
Tamiya,
Ngo,
Kelso,
Damiano,
Derian,
de Garavilla,
Smith,
Kawao,
Wada,
Darrow,
Ogawa,
Itoh,
Hunter,
Lockhart,
Kawabata,
Ye,
Sozzi,
Kawagoe,
Kanke,
Moffatt,
- Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. Damiano, B.P., Cheung, W.M., Santulli, R.J., Fung-Leung, W.P., Ngo, K., Ye, R.D., Darrow, A.L., Derian, C.K., de Garavilla, L., Andrade-Gordon, P. J. Pharmacol. Exp. Ther. (1999)
- Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. Su, X., Camerer, E., Hamilton, J.R., Coughlin, S.R., Matthay, M.A. J. Immunol. (2005)
- Deficiency of PAR-2 gene increases acute focal ischemic brain injury. Jin, G., Hayashi, T., Kawagoe, J., Takizawa, T., Nagata, T., Nagano, I., Syoji, M., Abe, K. J. Cereb. Blood Flow Metab. (2005)
- Down-regulation of trypsinogen expression is associated with growth retardation in {alpha}1,6-fucosyltransferase-deficient mice: attenuation of proteinase-activated receptor 2 activity. Li, W., Nakagawa, T., Koyama, N., Wang, X., Jin, J., Mizuno-Horikawa, Y., Gu, J., Miyoshi, E., Kato, I., Honke, K., Taniguchi, N., Kondo, A. Glycobiology (2006)
- Protease-activated receptor-2 augments experimental crescentic glomerulonephritis. Moussa, L., Apostolopoulos, J., Davenport, P., Tchongue, J., Tipping, P.G. Am. J. Pathol. (2007)
- Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. Redecha, P., Franzke, C.W., Ruf, W., Mackman, N., Girardi, G. J. Clin. Invest. (2008)
- Protease-activated receptor-2 exerts contrasting model-specific effects on acute experimental pancreatitis. Laukkarinen, J.M., Weiss, E.R., van Acker, G.J., Steer, M.L., Perides, G. J. Biol. Chem. (2008)
- Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Vergnolle, N., Bunnett, N.W., Sharkey, K.A., Brussee, V., Compton, S.J., Grady, E.F., Cirino, G., Gerard, N., Basbaum, A.I., Andrade-Gordon, P., Hollenberg, M.D., Wallace, J.L. Nat. Med. (2001)
- Essential role for proteinase-activated receptor-2 in arthritis. Ferrell, W.R., Lockhart, J.C., Kelso, E.B., Dunning, L., Plevin, R., Meek, S.E., Smith, A.J., Hunter, G.D., McLean, J.S., McGarry, F., Ramage, R., Jiang, L., Kanke, T., Kawagoe, J. J. Clin. Invest. (2003)
- A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Hansen, K.K., Sherman, P.M., Cellars, L., Andrade-Gordon, P., Pan, Z., Baruch, A., Wallace, J.L., Hollenberg, M.D., Vergnolle, N. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Protection against acute pancreatitis by activation of protease-activated receptor-2. Sharma, A., Tao, X., Gopal, A., Ligon, B., Andrade-Gordon, P., Steer, M.L., Perides, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats. Kawabata, A., Kawao, N., Itoh, H., Shimada, C., Takebe, K., Kuroda, R., Masuko, T., Kataoka, K., Ogawa, S. Neurosci. Lett. (2002)
- Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. Kawagoe, J., Takizawa, T., Matsumoto, J., Tamiya, M., Meek, S.E., Smith, A.J., Hunter, G.D., Plevin, R., Saito, N., Kanke, T., Fujii, M., Wada, Y. Jpn. J. Pharmacol. (2002)
- Cockroach allergen extract stimulates protease-activated receptor-2 (PAR-2) expressed in mouse lung fibroblast. Kondo, S., Helin, H., Shichijo, M., Bacon, K.B. Inflamm. Res. (2004)
- PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors. Zhao, A., Shea-Donohue, T. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. Camerer, E., Kataoka, H., Kahn, M., Lease, K., Coughlin, S.R. J. Biol. Chem. (2002)
- Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts. Chinni, C., de Niese, M.R., Jenkins, A.L., Pike, R.N., Bottomley, S.P., Mackie, E.J. J. Cell. Sci. (2000)
- Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice. Takizawa, T., Tamiya, M., Hara, T., Matsumoto, J., Saito, N., Kanke, T., Kawagoe, J., Hattori, Y. J. Pharmacol. Sci. (2005)
- Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea. Abey, H.T., Fairlie, D.P., Moffatt, J.D., Balzary, R.W., Cocks, T.M. J. Pharmacol. Exp. Ther. (2006)
- Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle. Cocks, T.M., Sozzi, V., Moffatt, J.D., Selemidis, S. Gastroenterology (1999)
- Protease-activated receptor 2 mediates the proinflammatory effects of synovial mast cells. Palmer, H.S., Kelso, E.B., Lockhart, J.C., Sommerhoff, C.P., Plevin, R., Goh, F.G., Ferrell, W.R. Arthritis Rheum. (2007)
- Stimulation of protease-activated receptor-2 inhibits airway eosinophilia, hyperresponsiveness and bronchoconstriction in a murine model of allergic inflammation. De Campo, B.A., Henry, P.J. Br. J. Pharmacol. (2005)
- Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. Lerner, D.J., Chen, M., Tram, T., Coughlin, S.R. J. Biol. Chem. (1996)
- Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice. Moffatt, J.D., Jeffrey, K.L., Cocks, T.M. Am. J. Respir. Cell Mol. Biol. (2002)
- Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Camerer, E., Qazi, A.A., Duong, D.N., Cornelissen, I., Advincula, R., Coughlin, S.R. Blood (2004)
- Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Camerer, E., Huang, W., Coughlin, S.R. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Involvement of neutrophil recruitment and protease-activated receptor 2 activation in the induction of IL-18 in mice. Ikawa, K., Nishioka, T., Yu, Z., Sugawara, Y., Kawagoe, J., Takizawa, T., Primo, V., Nikolic, B., Kuroishi, T., Sasano, T., Shimauchi, H., Takada, H., Endo, Y., Sugawara, S. J. Leukoc. Biol. (2005)
- Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. Yu, Z., Ahmad, S., Schwartz, J.L., Banville, D., Shen, S.H. J. Biol. Chem. (1997)
- Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinase. Wang, P., DeFea, K.A. Biochemistry (2006)
- Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation. Smith, R., Ransjö, M., Tatarczuch, L., Song, S.J., Pagel, C., Morrison, J.R., Pike, R.N., Mackie, E.J. J. Bone Miner. Res. (2004)
- Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells. Bertog, M., Letz, B., Kong, W., Steinhoff, M., Higgins, M.A., Bielfeld-Ackermann, A., Frömter, E., Bunnett, N.W., Korbmacher, C. J. Physiol. (Lond.) (1999)