Disease relevance of Ginger

• Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs [1].
• Beneficial effects of Zingiber officinale on goldthioglucose induced obesity [2].
• Our results demonstrated that crude extract of Zingiber officinale was able to reduce rat paw and skin edema induced by carrageenan, 48/80 compound and serotonin [3].
• Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats [4].

High impact information on Ginger

• Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome [5].
• The 2.1 A structure of a cysteine protease with proline specificity from ginger rhizome, Zingiber officinale [6].
• 5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale [7].
• Schum., Curcuma longa L. and Zingiber officinale Rosc. was studied [8].
• Amino-acid sequence and glycan structures of cysteine proteases with proline specificity from ginger rhizome Zingiber officinale [9].

Biological context of Ginger

• When rhizome juice of ginger, zingiber officinale, was added to a solution of 2(2-furyl)-3(5-nitro-2-fury)acryl amide (AF2) or N-methyl-N'-nitro-N-nitrosoguanidine (NTG), mutagenesis by these chemicals was markedly increased [10].
• Gingerol content of diploid and tetraploid clones of ginger (Zingiber officinale Roscoe) [11].
• Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale) [12].
• "Trikatu"-an Ayurvedic formulation comprising of a 1:1:1 ratio of dried fruits of Piper nigrum, Piper longum and dried rhizomes of Zingiber officinale is widely used to enhance the bioavailability of drugs, like vasicine, indomethacin, etc [13].

Associations of Ginger with chemical compounds

• The effectiveness of ginger (Zingiber officinale) as an antiemetic agent was compared with placebo and metoclopramide in 60 women who had major gynaecological surgery in a double-blind, randomised study [14].
• The effect of an aqueous extract of ginger (Zingiber officinale) on serum cholesterol and triglyceride levels as well as platelet thromboxane-B(2) and prostaglandin-E(2) production was examined [15].
• Antiplatelet effect of gingerol isolated from Zingiber officinale [16].
• The metabolic fate of [6]-gingerol, one of the active constituents of Zingiber officinale Roscoe, was investigated using rats [17].
• Previous work has shown that Zingicomb (ZC), a combination preparation of zingiber officinale and ginkgo biloba, exerts anxiolytic-like effects in the elevated plus-maze (EPM), possibly related to 5-HT antagonistic properties of its components [18].

Gene context of Ginger

• Seventeen pungent oleoresin principles of ginger (Zingiber officinale, Roscoe) and synthetic analogues were evaluated for inhibition of cyclooxygenase-2 (COX-2) enzyme activity in the intact cell [19].
• Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production [20].
• Ginger (Zingiber officinale Roscoe) shows an antioxidant activity, and we have been engaging to determine the structures of more than 50 antioxidants isolated from the rhizomes of ginger [21].
• Cholesterol biosynthesis inhibitory component from Zingiber officinale Roscoe [22].
• The teratogenicity of EV.EXT 33, a patented Zingiber officinale extract, was examined in Wistar SPF rats according to GLP Guidelines [23].

Analytical, diagnostic and therapeutic context of Ginger

• Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro [24].

References