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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Wrist Joint

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Disease relevance of Wrist Joint


High impact information on Wrist Joint

  • The reflex responses evoked by the ball's impact consisted in a short-latency coactivation of flexor and extensor muscles at the elbow and wrist joints [4].
  • Levels of MMP-2 were approximately 1.5-fold higher in invasive tenosynovium compared with both encapsulating tenosynovium and wrist joint synovium [5].
  • The maximal wrist joint velocity of self-paced reciprocating flexion and extension movements increased after levodopa (ON), without significant changes in the movement period or amplitude [6].
  • The clearance rates of free iodide and of radioiodinated serum albumin were measured in the knee and wrist joints of 9 normal adult dogs [7].
  • The movements were preceded (2-3 s) by four different conditioning routines: 40-s rest (Rest), 10-s voluntary alternating wrist joint flexion and extension movements (Osc), and 10 s of 25 degrees weak isometric wrist extensor (Ext) or flexor contractions (Flex) [8].

Biological context of Wrist Joint


Anatomical context of Wrist Joint


Associations of Wrist Joint with chemical compounds

  • Radioactive 2-deoxy-D-glucose (2-DG) incorporation into the monkey prefrontal and premotor cortex was studied in relation to extention-flexion movement at the wrist joint in two experimental and two control monkeys [12].
  • The polished surfaces of hip, knee and wrist joints made of Ti-6Al-7Nb and articulating against polyethylene are surface-treated by means of a very hard and 3-5 microns thick titanium nitride coating (Tribosul-TiN) or by oxygen diffusion hardening (Tribosul-ODH) to a depth of 30 microns [13].
  • Arthrography using 60 per cent Urografin was done on twenty fresh cadaver wrist joints [14].
  • In substudy 2, we evaluated 19 sets of 2nd-5th MCP joints [10 sets from UK (Technique A) and 9 sets from the US (Technique B: 1.5 T; coronal T1 spin-echo and T2* gradient-echo + FS, no Gd)] and 19 wrist joints [9 from the US (Technique B) and 10 from Denmark (Technique C: 1.0 T; coronal and axial T1 spin-echo, no FS, -/+ Gd)] [15].
  • Increased serum levels of alpha 1-antitrypsin were independently associated (p less than 0.01) with the presence of wrist joint erosions and the use of gold and/or penicillamine for treatment; this association may represent a serum antitrypsin response to more severe disease [16].

Gene context of Wrist Joint

  • METHODS: Synovial specimens were obtained from encapsulating tenosynovium (n = 17), invasive tenosynovium (n = 13), and wrist joints (n = 17) in 18 RA patients undergoing wrist extensor tenosynovectomy [5].
  • The outcome was poor in patients with early signs of radiological destruction in the joints, with rheumatoid factor in serum, with early functional disability or deficient flexion of the fingers, with multiple affliction of the finger, metatarsophalangeal or wrist joints, with marked morning stiffness, and with CRP in the serum [17].
  • Linear regression analysis of wrist joint laxity and level of serum estradiol, progesterone, and relaxin demonstrated no significant correlation [18].
  • Wrist joint involvement in systemic lupus erythematosus. An ultrasonographic study [19].
  • We conclude that a cystic radiolucency observed in the wrist joint of a patient undergoing HD indicates the deposition of amyloid [20].

Analytical, diagnostic and therapeutic context of Wrist Joint


  1. Magnetic resonance imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis. Ejbjerg, B., Narvestad, E., Rostrup, E., Szkudlarek, M., Jacobsen, S., Thomsen, H.S., Østergaard, M. Arthritis Rheum. (2004) [Pubmed]
  2. Clinical application of ultrasonography for detection of septic arthritis in children. Tien, Y.C., Chih, H.W., Lin, G.T., Hsien, S.H., Lin, S.Y. The Kaohsiung journal of medical sciences. (1999) [Pubmed]
  3. Transfer of innervated split latissimus dorsi free musculocutaneous flap for flexion and extension of the fingers. Ortak, T., Uraloğlu, M., Orbay, H., Tekin, F., Unlü, R.E., Sensöz, O. Annals of plastic surgery. (2006) [Pubmed]
  4. The role of preparation in tuning anticipatory and reflex responses during catching. Lacquaniti, F., Maioli, C. J. Neurosci. (1989) [Pubmed]
  5. Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis. Jain, A., Nanchahal, J., Troeberg, L., Green, P., Brennan, F. Arthritis Rheum. (2001) [Pubmed]
  6. Acute effects of levodopa on wrist movement in Parkinson's disease. Kinematics, volitional EMG modulation and reflex amplitude modulation. Johnson, M.T., Mendez, A., Kipnis, A.N., Silverstein, P., Zwiebel, F., Ebner, T.J. Brain (1994) [Pubmed]
  7. Iodide and albumin kinetics in normal canine wrists and knees. Simkin, P.A., Benedict, R.S. Arthritis Rheum. (1990) [Pubmed]
  8. Signs of muscle thixotropy during human ballistic wrist joint movements. Axelson, H.W. J. Appl. Physiol. (2005) [Pubmed]
  9. Anchorage of wrist joint prostheses to bone using the osseointegration principle. Lundborg, G., Brånemark, P.I. Journal of hand surgery (Edinburgh, Lothian) (1997) [Pubmed]
  10. Carpal bone kinematics and ligament lengthening studied for the full range of joint movement. Savelberg, H.H., Otten, J.D., Kooloos, J.G., Huiskes, R., Kauer, J.M. Journal of biomechanics. (1993) [Pubmed]
  11. Excursion of prime wrist tendons. Horii, E., An, K.N., Linscheid, R.L. The Journal of hand surgery. (1993) [Pubmed]
  12. Radioactive 2-deoxy-D-glucose incorporation into the prefrontal and premotor cortex of the monkey performing a forelimb movement. Matsunami, K., Kageyama, T., Kubota, K. Neurosci. Lett. (1981) [Pubmed]
  13. Joint replacement components made of hot-forged and surface-treated Ti-6Al-7Nb alloy. Semlitsch, M.F., Weber, H., Streicher, R.M., Schön, R. Biomaterials (1992) [Pubmed]
  14. Arthrography of the wrist joint. An experimental study. Mikić, Z.D. The Journal of bone and joint surgery. American volume. (1984) [Pubmed]
  15. Interreader agreement in the assessment of magnetic resonance images of rheumatoid arthritis wrist and finger joints--an international multicenter study. Ostergaard, M., Klarlund, M., Lassere, M., Conaghan, P., Peterfy, C., McQueen, F., O'Connor, P., Shnier, R., Stewart, N., McGonagle, D., Emery, P., Genant, H., Edmonds, J. J. Rheumatol. (2001) [Pubmed]
  16. Relationship between severity of rheumatoid arthritis and serum alpha 1-antitrypsin. Abboud, R.T., Chalmers, A., Gofton, J.P., Richter, A.M., Enarson, D.A. J. Rheumatol. (1991) [Pubmed]
  17. Predicting the outcome of rheumatoid arthritis. A Soviet-Finnish co-operative study. Isomäki, H., Martio, J., Sarna, S., Kiviniemi, P., Akimova, T., Ievleva, L., Mylov, N., Trofimova, T. Scand. J. Rheumatol. (1984) [Pubmed]
  18. Characterization of the relationship between joint laxity and maternal hormones in pregnancy. Marnach, M.L., Ramin, K.D., Ramsey, P.S., Song, S.W., Stensland, J.J., An, K.N. Obstetrics and gynecology. (2003) [Pubmed]
  19. Wrist joint involvement in systemic lupus erythematosus. An ultrasonographic study. Iagnocco, A., Ossandon, A., Coari, G., Conti, F., Priori, R., Alessandri, C., Valesini, G. Clinical and experimental rheumatology. (2004) [Pubmed]
  20. Cystic radiolucencies of carpal bones, distal radius and ulna as a marker for dialysis-associated amyloid osteoarthropathy. Homma, N., Gejyo, F., Kobayashi, H., Saito, H., Sakai, S., Suzuki, M., Hirasawa, Y., Arakawa, M. Nephron (1992) [Pubmed]
  21. Contrast-enhanced dynamic and static MRI correlates with quantitative 99Tcm-labelled nanocolloid scintigraphy. Study of early rheumatoid arthritis patients. Palosaari, K., Vuotila, J., Takalo, R., Jartti, A., Niemelä, R., Haapea, M., Soini, I., Tervonen, O., Hakala, M. Rheumatology (Oxford, England) (2004) [Pubmed]
  22. Design of a total wrist prosthesis. Youm, Y., Flatt, A.E. Annals of biomedical engineering. (1984) [Pubmed]
  23. Interpositional arthroplasty of the wrist in rheumatoid arthritis. Jackson, I.T., Simpson, R.G. The Hand. (1979) [Pubmed]
  24. Arthrodesis of the wrist joint in rheumatoid arthritis. Mikkelsen, O.A. The Hand. (1980) [Pubmed]
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