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Chemical Compound Review

Verografin     sodium;3,5-diacetamido-2,4,6- triiodo...

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Disease relevance of Verografin


High impact information on Verografin


Chemical compound and disease context of Verografin

  • Niopam may be a safer contrast medium than Urografin for retrograde pancreatography, particularly in patients in whom the risk of acute pancreatitis is high [10].
  • Additionally, the lumbar spinal units of 25 fresh cadavers were roentgenographed, injected with a mixture of methylene blue and renografin-60, dissected, and studied [11].
  • The degree of albuminuria following hephroangiography with the ionic contrast medium Urografin, the non-ionic Amipaque and a recently synthesized non-ionic contrast medium with the code name C 29 was compared [12].

Biological context of Verografin


Anatomical context of Verografin


Associations of Verografin with other chemical compounds


Gene context of Verografin

  • A statistically significant increase was seen in the Iopromid group and no statistically significant rise was seen in the Uropolinum group. t-PA activity remained virtually unchanged in both groups [27].
  • Furthermore, HRPTE cells increased (3-4 fold) AQP-1 expression when exposed to hyperosmolar Reno-60 and Hypaque-76 (diatrizoates, ionic) contrast agents at 400 and 500 mOsm/kg.H2O [28].
  • The contrast media caused comparable decreases in P50 from this value (Hypaque-76, 20.0 +/- 0.5 mm Hg; Omnipaque-350, 21.6 +/- 0.4 mm Hg; Isovue-370, 20.7 +/- 0.4 mm Hg) [22].
  • Buoyant density centrifugation in Urografin solutions resolved French Pressure Cell-sheared, and micrococcal nuclease-digested avian reticulocyte chromatin into a broad profile of two peaks [29].
  • Cytogenetic effects of two ionic contrast media (CM), Urografin 76% a sodium-meglumine diatrizoate, and Telebrix 38, a sodium-meglumine ioxythalamate, were tested on lymphocytes of patients undergoing brain CT Scan. Both compounds have approximately similar iodine concentrations [17].

Analytical, diagnostic and therapeutic context of Verografin


  1. Effect of calcium-binding additives on ventricular fibrillation and repolarization changes during coronary angiography. Zukerman, L.S., Friehling, T.D., Wolf, N.M., Meister, S.G., Nahass, G., Kowey, P.R. J. Am. Coll. Cardiol. (1987) [Pubmed]
  2. Cervical myelopathy complicating cerebral angiography. Report of a case and review of the literature. Ramirez-Lassepas, M., McClelland, R.R., Snyder, B.D., Marsh, D.G. Neurology (1977) [Pubmed]
  3. The haemodynamic effects of left ventriculography in coronary artery disease and mitral valve disease: a comparison of high and low osmolality contrast media. Fraser, A.G., Culling, W., Singh, H., Ruttley, M.S., Newcombe, R.G. Eur. Heart J. (1984) [Pubmed]
  4. Water-soluble contrast study predicts the need for early surgery in adhesive small bowel obstruction. Chen, S.C., Lin, F.Y., Lee, P.H., Yu, S.C., Wang, S.M., Chang, K.J. The British journal of surgery. (1998) [Pubmed]
  5. DNA-binding proteins specified by herpesvirus saimiri. Blair, E.D., Honess, R.W. J. Gen. Virol. (1983) [Pubmed]
  6. Reflex vasodilation induced by coronary angiography in human subjects. Zelis, R., Caudill, C.C., Baggette, K., Mason, D.T. Circulation (1976) [Pubmed]
  7. Changes in QTc interval induced with Renografin-76 and Hypaque-76 during coronary arteriography. Wolf, G.L., Hirshfeld, J.W. J. Am. Coll. Cardiol. (1983) [Pubmed]
  8. Effect of atriopeptin II on contrast medium-induced changes in renal blood flow. Bentley, M.D., Fiksen-Olsen, M.J., Romero, J.C. Kidney Int. (1989) [Pubmed]
  9. High-dose clinical urography with the low-osmolality contrast agent Hexabrix: comparison with a conventional contrast agent. Spataro, R.F., Katzberg, R.W., Fischer, H.W., McMannis, M.J. Radiology. (1987) [Pubmed]
  10. Iopamidol as contrast medium in endoscopic retrograde pancreatography: a prospective randomised comparison with diatrizoate. O'Connor, H.J., Ellis, W.R., Manning, A.P., Lintott, D.J., McMahon, M.J., Axon, A.T. Endoscopy. (1988) [Pubmed]
  11. Annular protrusion: pathophysiology and roentgenographic appearance. Kambin, P., Nixon, J.E., Chait, A., Schaffer, J.L. Spine. (1988) [Pubmed]
  12. Proteinuria following nephroangiography. IV. Comparison in dogs between ionic and non-ionic contrast media. Holtås, S., Tejler, L. Acta radiologica: diagnosis. (1979) [Pubmed]
  13. Reactions to intravenous contrast media. Part I: Severe and fatal cardiovascular reactions in a canine dehydration model. Katzberg, R.W., Morris, T.W., Schulman, G., Faillace, R.T., Boylan, L.M., Foley, M.J., Spataro, R.F., Fischer, H.W. Radiology. (1983) [Pubmed]
  14. Inhibition of platelet aggregation by contrast media. Gafter, U., Creter, D., Zevin, D., Catz, R., Djaldetti, M. Radiology. (1979) [Pubmed]
  15. Effects of radiocontrast and endothelin administration on systolic blood pressure and renal damage in male spontaneously hypertensive and Wistar Kyoto rats with phentolamine-induced adrenergic blockade. Duarte, C.G., Zhang, J., Ellis, S. Investigative radiology. (1998) [Pubmed]
  16. The hemodynamic effects of the administration of ionic and nonionic contrast materials into the pulmonary arteries of a canine model of acute pulmonary hypertension. Rees, C.R., Palmaz, J.C., Garcia, O., Alvarado, R., Siegle, R.L. Investigative radiology. (1988) [Pubmed]
  17. Similar cytogenetic effects of sodium-meglumine diatrizoate and sodium-meglumine ioxithalamate in lymphocytes of patients undergoing brain CT scan. Mozdarani, H., Fadaei, S. Toxicol. Lett. (1998) [Pubmed]
  18. Extravascular lung water: effects of intravenous ionic and non-ionic (lopamidol) contrast media during ischemia. Slutsky, R.A., Strich, G. Radiology. (1985) [Pubmed]
  19. Percutaneous management of renal cysts: results of a four-year study. Raskin, M.M., Poole, D.O., Roen, S.A., Viamonte, M. Radiology. (1975) [Pubmed]
  20. Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. Tooke, N.E., Hales, C.N., Hutton, J.C. Biochem. J. (1984) [Pubmed]
  21. Lipid-mediated glycosylation of endogenous proteins in isolated plasma membrane of Saccharomyces cerevisiae. Welten-Verstegen, G.W., Boer, P., Steyn-Parvé, E.P. J. Bacteriol. (1980) [Pubmed]
  22. Contrast media adversely affect oxyhemoglobin dissociation. Kim, S.J., Salem, M.R., Joseph, N.J., Madayag, M.A., Cavallino, R.P., Crystal, G.J. Anesth. Analg. (1990) [Pubmed]
  23. Myocardial ischemia during intravenous DSA in patients with cardiac disease. Hesselink, J.R., Hayman, L.A., Chung, K.J., McGinnis, B.D., Davis, K.R., Taveras, J.M. Radiology. (1984) [Pubmed]
  24. The effect of contrast media on patient motion during cerebral angiography. Dempsey, P.J., Goree, J.A., Jimenez, J.P., McCord, G.M. Radiology. (1975) [Pubmed]
  25. Contrast bolus dynamic computed tomography for the measurement of solid organ perfusion. Blomley, M.J., Coulden, R., Bufkin, C., Lipton, M.J., Dawson, P. Investigative radiology. (1993) [Pubmed]
  26. Sinus slowing produced by intracoronary arterial injections of hyperosmotic solutions in man. Abe, S., Itoh, M., Unakami, H., Kobayashi, T. Am. Heart J. (1976) [Pubmed]
  27. Effect of nonionic and ionic contrast media on fibrinolysis in patients undergoing angiography. Giedrojć, J., Radziwon, P., Krupiński, K., Kiełpińska, K., Galar, M., Bielawiec, M. Polish journal of pharmacology. (1996) [Pubmed]
  28. Aquaporin-1 expression in proximal tubule epithelial cells of human kidney is regulated by hyperosmolarity and contrast agents. Jenq, W., Cooper, D.R., Bittle, P., Ramirez, G. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  29. Distribution of globin genes in chicken reticulocyte chromatin fractionated on urografin gradients. Willetts, B.C., Wells, J.R. Mol. Biol. Rep. (1976) [Pubmed]
  30. Hexabrix as a contrast agent for hysterosalpingography. Winfield, A.C., Maxson, W.S., Harding, D.R., Diggs, J., Wentz, A.C. Radiology. (1984) [Pubmed]
  31. Biochemical composition of lymphocytic choriomeningitis virus interfering particles. Peralta, L.M., Bruns, M., Lehmann-Grube, F. J. Gen. Virol. (1981) [Pubmed]
  32. Arthrography of the wrist joint. An experimental study. Mikić, Z.D. The Journal of bone and joint surgery. American volume. (1984) [Pubmed]
  33. Intravenous angiocardiography using digital image processing: I. Experience with axial projections in normal pigs. Bogren, H.G., Bürsch, J.H., Brennecke, R., Heintzen, P.H. Investigative radiology. (1982) [Pubmed]
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