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MeSH Review

Particle Accelerators

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Disease relevance of Particle Accelerators


High impact information on Particle Accelerators

  • In study 2, patients received high-dose oral prednisone for 6 months (initial dosage, 80 to 100 mg/d) and underwent orbital radiation therapy by linear accelerator (cumulative dose, 20 Gy per eye over 2 weeks) [6].
  • For this purpose, xanthine (X) and xanthine oxidase (XOD) were employed as an O2.- (-)generating system, and a linear accelerator was used for ionizing radiation [7].
  • The effect of whole body ionising radiation from a linear accelerator on rat tissue O6-methylguanine (O6-meG) methyltransferase (MT) activity has been assessed using an assay which measures the transfer of 3H-radioactivity from 3H-methylated substrate DNA to protein [8].
  • Results show the similarity and adequacy of the neck dose distribution using photon beams from cobalt 60, a 4-MV linear accelerator with an external filter, and a 10-MV linear accelerator [9].
  • Equipment used for this purpose includes a Mevatron XII linear accelerator, redesigned for automatic control, and a PDP 11/45 minicomputer [10].

Biological context of Particle Accelerators


Anatomical context of Particle Accelerators


Associations of Particle Accelerators with chemical compounds


Gene context of Particle Accelerators

  • To investigate the effect of beam characteristics on dose distributions, a three-dimensional TPS was used to calculate the isodose distributions for three different linear accelerators, the Varian Clinac 6/100, the Siemens MD2 and the Philips SL/7 for the three patients [19].
  • Evaluation of linear accelerator radiosurgical techniques using biophysical parameters (NTCP and TCP) [20].
  • By a three-dimensional planning system (TMS, Helax 6.1B) the irradiation was planned for an 18-MV linear accelerator (Primus 1, Siemens) [21].
  • MATERIAL AND METHODS: The method of fabrication of wedge shaped midline block is discussed for treatment of early stage cervical cancers based on the configuration of 137Cs pellets used in intracavitary applications and along with external photon beams obtained by using 60Co teletherapy machine and 6 and 10 MV linear accelerators [22].
  • The treatment plans were generated with HELIOS for delivery with 6 MV on a CL2100 Varian linear accelerator with a 26 pair MLC [23].

Analytical, diagnostic and therapeutic context of Particle Accelerators


  1. Leukemia patient-derived lymphoblastoid cell lines exhibit increased induction of leukemia-associated transcripts following high-dose irradiation. Spencer, A., Granter, N. Exp. Hematol. (1999) [Pubmed]
  2. Splenic irradiation in chronic lymphocytic leukemia. A 10-year experience at a single institution. Roncadin, M., Arcicasa, M., Trovó, M.G., Franchin, G., de Paoli, A., Volpe, R., Carbone, A., Tirelli, U., Grigoletto, E. Cancer (1987) [Pubmed]
  3. Effect of total body irradiation on peri-implant tissue reaction: an experimental study. Renou, S.J., Guglielmotti, M.B., de la Torre, A., Cabrini, R.L. Clinical oral implants research. (2001) [Pubmed]
  4. Survival and management considerations in postirradiation osteosarcoma and Paget's osteosarcoma. Frassica, F.J., Sim, F.H., Frassica, D.A., Wold, L.E. Clin. Orthop. Relat. Res. (1991) [Pubmed]
  5. Tumour regression of uveal melanoma after ruthenium-106 brachytherapy or stereotactic radiotherapy with gamma knife or linear accelerator. Georgopoulos, M., Zehetmayer, M., Ruhswurm, I., Toma-Bstaendig, S., Ségur-Eltz, N., Sacu, S., Menapace, R. Ophthalmologica (2003) [Pubmed]
  6. Cigarette smoking and treatment outcomes in Graves ophthalmopathy. Bartalena, L., Marcocci, C., Tanda, M.L., Manetti, L., Dell'Unto, E., Bartolomei, M.P., Nardi, M., Martino, E., Pinchera, A. Ann. Intern. Med. (1998) [Pubmed]
  7. Role of intracellular SOD in protecting human leukemic and cancer cells against superoxide and radiation. Yamaguchi, S., Sakurada, S., Nagumo, M. Free Radic. Biol. Med. (1994) [Pubmed]
  8. O6-Methylguanine methyltransferase activity is increased in rat tissues by ionising radiation. Margison, G.P., Butler, J., Hoey, B. Carcinogenesis (1985) [Pubmed]
  9. A measurement of doses to the neck for mantle field treatment of lymphomas with cobalt-60, 4-, and 10-MV photon beams. McCullough, E.C., Earle, J.D. Radiology. (1982) [Pubmed]
  10. Computer-controlled radiation therapy. Levene, M.B., Kijewski, P.K., Chin, L.M., Bjärngard, B.E., Hellman, S. Radiology. (1978) [Pubmed]
  11. Stereotactic radiosurgery: principles and comparison of treatment methods. Luxton, G., Petrovich, Z., Jozsef, G., Nedzi, L.A., Apuzzo, M.L. Neurosurgery (1993) [Pubmed]
  12. Impairment of optic path due to radiotherapy for nasopharyngeal carcinoma. Hu, W.H., Yu, M.Z., Long, S.X., Huang, S.Z., Gu, M.F., Zhou, L.S., Wu, D.Z. Documenta ophthalmologica. Advances in ophthalmology. (2003) [Pubmed]
  13. Effect of ionizing radiation on artificial (planar) lipid membranes. II. The ion carriers valinomycin and nonactin as probes for radiation induced structural changes of the membrane. Strässle, M., Stark, G., Wilhelm, M. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1987) [Pubmed]
  14. Mantle field dosimetry comparing 4 MV with cobalt 60. Gray, L., Prosnitz, L.R. Radiology. (1975) [Pubmed]
  15. A linear accelerator couch attachment for extended SSD treatments. Biggs, P.J., Leong, J.C. Int. J. Radiat. Oncol. Biol. Phys. (1983) [Pubmed]
  16. The Los Alamos Scientific Laboratory ion linear accelerator program. Knapp, E.A., Swenson, D.A. Int. J. Radiat. Oncol. Biol. Phys. (1977) [Pubmed]
  17. Current calibration, treatment, and treatment planning techniques among institutions participating in the Children's Oncology Group. Urie, M., FitzGerald, T.J., Followill, D., Laurie, F., Marcus, R., Michalski, J. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  18. An isodose shift technique for obliquely incident electron beams. Ulin, K., Sternick, E.S. Medical physics. (1989) [Pubmed]
  19. Dosimetric comparison of treatment planning systems in irradiation of breast with tangential fields. Cheng, C.W., Das, I.J., Tang, W., Chang, S., Tsai, J.S., Ceberg, C., De Gaspie, B., Singh, R., Fein, D.A., Fowble, B. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
  20. Evaluation of linear accelerator radiosurgical techniques using biophysical parameters (NTCP and TCP). Colombo, F., Francescon, P., Cora, S., Testolin, A., Chierego, G. Int. J. Radiat. Oncol. Biol. Phys. (1995) [Pubmed]
  21. Radiotherapy of prostate cancer with multileaf collimators (MLCs) optimization of the undulating dose distribution at the MLC edge. Koelbl, O., Schwab, F., Bratengeier, K., Vordermark, D., Flentje, M. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (2005) [Pubmed]
  22. Design and comparison of wedge shaped midline block with rectangular block used in early stage cervical cancers. Avadhani, J.S., Deshpande, D.D., Pradhan, A.S., Viswanathan, P.S., Shrivastava, S.K., Dinshaw, K.A. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1996) [Pubmed]
  23. A method of calculating a lung clinical target volume DVH for IMRT with intrafractional motion. Kung, J.H., Zygmanski, P., Choi, N., Chen, G.T. Medical physics. (2003) [Pubmed]
  24. Successful engraftment of NA1 positive bone marrow in a patient with a neutrophil antibody, anti-NA1. Warkentin, P.I., Clay, M.E., Kersey, J.H., Ramsay, N.K., McCullough, J. Hum. Immunol. (1981) [Pubmed]
  25. Wide dynamic dose range of VIPAR polymer gel dosimetry. Kipouros, P., Pappas, E., Baras, P., Hatzipanayoti, D., Karaiskos, P., Sakelliou, L., Sandilos, P., Seimenis, I. Physics in medicine and biology. (2001) [Pubmed]
  26. Use of a blood glucose meter for radiochromic film analysis in blood irradiation. Cheung, T., Butson, M.J., Yu, P.K. Physics in medicine and biology. (2002) [Pubmed]
  27. The physical, biologic, and clinical basis of radiosurgery. Mehta, M.P. Current problems in cancer. (1995) [Pubmed]
  28. Cobalt 60 versus 15 MeV photons during total body irradiation: doses in the critical organs and complexicity of the procedure. Malicki, J., Kosicka, G., Stryczyńska, G., Wachowiak, J. Ann. Transplant. (2001) [Pubmed]
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