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MeSH Review

Spleen Focus-Forming Viruses

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Disease relevance of Spleen Focus-Forming Viruses


High impact information on Spleen Focus-Forming Viruses


Chemical compound and disease context of Spleen Focus-Forming Viruses


Biological context of Spleen Focus-Forming Viruses


Anatomical context of Spleen Focus-Forming Viruses


Gene context of Spleen Focus-Forming Viruses

  • A frequent event in the generation of these malignant cells is deregulation of the hematopoietic-specific transcription factor PU.1 (Spi-1) by retroviral insertion of the spleen-focus-forming virus component of Friend virus [26].
  • The nonresponsiveness to Epo presumably results from gp55, the product of the env gene encoded by the Friend spleen focus-forming virus (F-SFFV), acting as a pseudoligand and constitutively activating the receptor [27].
  • The positions of a 585-base deletion, a 6-base duplication, and a point insertion that leads to a frame shift and premature protein termination in the ecotropic 3' end of env were invariant between three spleen focus-forming virus strains, indicating that they had a single common ancestor [28].
  • The FMEV-type vector SF/Lyt contained the spleen focus-forming virus U3 and the MESV primer-binding site (PBS), while MO3/Lyt contained the U3 region and PBS from Mo-MuLV [29].
  • IL-7 significantly prolonged survival time and decreased spleen focus-forming virus (SFFV) levels, expression of SFFV mRNA and SFFV protein production in FVC-infected mice [30].

Analytical, diagnostic and therapeutic context of Spleen Focus-Forming Viruses


  1. Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Ben-David, Y., Giddens, E.B., Letwin, K., Bernstein, A. Genes Dev. (1991) [Pubmed]
  2. Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus. Risser, R. J. Exp. Med. (1979) [Pubmed]
  3. Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor growth. Pharr, P.N., Hankins, D., Hofbauer, A., Lodish, H.F., Longmore, G.D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Immunoselection of mutants deficient in cell surface glycoproteins encoded by murine erythroleukemia viruses. Kabat, D., Ruta, M., Murray, M.J., Polonoff, E. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  5. Loss of leukemogenicity caused by mutations in the membrane glycoprotein structural gene of Friend spleen focus-forming virus. Ruta, M., Bestwick, R., Machida, C., Kabat, D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  6. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Yoshimura, A., Longmore, G., Lodish, H.F. Nature (1990) [Pubmed]
  7. Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Li, J.P., D'Andrea, A.D., Lodish, H.F., Baltimore, D. Nature (1990) [Pubmed]
  8. Malignant transformation of erythroid cells in vivo by introduction of a nonreplicating retrovirus vector. Wolff, L., Ruscetti, S. Science (1985) [Pubmed]
  9. Employment of a [3H]thymidine-incorporation assay to distinguish the effects of different Friend erythroleukemia-inducing retroviruses on erythroid cell proliferation. Ruscetti, S.K. J. Natl. Cancer Inst. (1986) [Pubmed]
  10. Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells. Aizawa, S., Suda, Y., Furuta, Y., Yagi, T., Takeda, N., Watanabe, N., Nagayoshi, M., Ikawa, Y. EMBO J. (1990) [Pubmed]
  11. Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus. Dube, S.K., Pragnell, I.B., Kluge, N., Gaedicke, G., Steinheider, G., Ostertag, W. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  12. Effects of in vivo Friend leukemia virus infection on levels of serum thymic factors and on selected T-cell functions in mice. Tonietti, G., Rossi, G.B., Del Gobbo, V., Accinni, L., Ranucci, A., Titti, F., Premrov, M.G., Garaci, E. Cancer Res. (1983) [Pubmed]
  13. Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor. Yoshimura, A., Zimmers, T., Neumann, D., Longmore, G., Yoshimura, Y., Lodish, H.F. J. Biol. Chem. (1992) [Pubmed]
  14. Ex vivo and in vivo biological effects of a truncated form of the receptor tyrosine kinase stk when activated by interaction with the friend spleen focus-forming virus envelope glycoprotein or by point mutation. Rulli, K., Yugawa, T., Hanson, C., Thompson, D., Ruscetti, S., Nishigaki, K. J. Virol. (2004) [Pubmed]
  15. Dimethyl sulfoxide affects the amount of extrachromosomal spleen focus-forming virus DNA in murine erythroleukemia cells. Kern, F.G., Axelrod, D.E. J. Virol. (1983) [Pubmed]
  16. Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line. Hino, M., Tojo, A., Misawa, Y., Morii, H., Takaku, F., Shibuya, M. Mol. Cell. Biol. (1991) [Pubmed]
  17. Familial and congenital polycythemia in three unrelated families. Emanuel, P.D., Eaves, C.J., Broudy, V.C., Papayannopoulou, T., Moore, M.R., D'Andrea, A.D., Prchal, J.F., Eaves, A.C., Prchal, J.T. Blood (1992) [Pubmed]
  18. The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Moreau-Gachelin, F., Ray, D., Mattei, M.G., Tambourin, P., Tavitian, A. Oncogene (1989) [Pubmed]
  19. A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic. Watanabe, N., Nishi, M., Ikawa, Y., Amanuma, H. J. Virol. (1990) [Pubmed]
  20. Evidence for a new form of retroviral env transcript in leukemic and normal mouse lymphoid cells. Boccara, M., Souyri, M., Magarian, C., Stavnezer, E., Fleissner, E. J. Virol. (1983) [Pubmed]
  21. Erythroid colony induction without erythropoietin by Friend leukemia virus in vitro. Clarke, B.J., Axelrad, A.A., Shreeve, M.M., McLeod, D.L. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  22. Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line. Showers, M.O., DeMartino, J.C., Saito, Y., D'Andrea, A.D. Mol. Cell. Biol. (1993) [Pubmed]
  23. Expression of xenotropic-like env RNA sequences in normal DBA/2 and NZB mouse tissues. Lee, E.J., Kaminchik, J., Hankins, W.D. J. Virol. (1984) [Pubmed]
  24. Leukemogenic membrane glycoprotein encoded by Friend spleen focus-forming virus: transport to cell surfaces and shedding are controlled by disulfide-bonded dimerization and by cleavage of a hydrophobic membrane anchor. Gliniak, B.C., Kabat, D. J. Virol. (1989) [Pubmed]
  25. Growth factor-independent proliferation of erythroid cells infected with Friend spleen focus-forming virus is protein kinase C dependent but does not require Ras-GTP. Muszynski, K.W., Thompson, D., Hanson, C., Lyons, R., Spadaccini, A., Ruscetti, S.K. J. Virol. (2000) [Pubmed]
  26. Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Rao, G., Rekhtman, N., Cheng, G., Krasikov, T., Skoultchi, A.I. Oncogene (1997) [Pubmed]
  27. Role of gp55 in restoring the sensitivity of Friend murine erythroleukemia cells to erythropoietin by exposure to dimethyl sulfoxide. Lin, T.S., Ishiguro, K., Sartorelli, A.C. Oncol. Res. (1998) [Pubmed]
  28. Fluidity of a retrovirus genome. Clark, S.P., Mak, T.W. J. Virol. (1984) [Pubmed]
  29. Retroviral vector-mediated gene expression in human CD34+CD38- cells expanded in vitro: cis elements of FMEV are superior to those of Mo-MuLV. Tsuji, T., Itoh, K., Baum, C., Ohnishi, N., Tomiwa, K., Hirano, D., Nishimura-Morita, Y., Ostertag, W., Fujita, J. Hum. Gene Ther. (2000) [Pubmed]
  30. Influence of recombinant human interleukin (IL)-7 on disease progression in mice infected with Friend virus complex. Lu, L., Zhou, Z., Wu, B., Xiao, M., Shen, R.N., Williams, D.E., Kim, Y.J., Kwon, B.S., Ruscetti, S., Broxmeyer, H.E. Int. J. Cancer (1992) [Pubmed]
  31. Impeded progression of Friend disease in mice by an inhibitor of retroviral proteases. Lai, M.H., Tang, J., Wroblewski, V., Dee, A.G., Margolin, N., Vlahos, C., Bowdon, B., Buckheit, R., Colacino, J., Hui, K.Y. J. Acquir. Immune Defic. Syndr. (1993) [Pubmed]
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