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MeSH Review

Legionellosis

 
 
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Disease relevance of Legionellosis

 

High impact information on Legionellosis

  • Induction of IL-10 may be a virulence mechanism that promotes intracellular bacterial replication in human legionellosis [4].
  • Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis [5].
  • However, in this murine model of pulmonary legionellosis, SCH27899, like OFX and AZI, was bacteriostatic [6].
  • To determine whether endogenous TNF-alpha is necessary for host defense against legionellosis in vivo, anti-TNF-alpha IgG or control IgG was administered to rats exposed to aerosolized L. pneumophila [7].
  • PBLs of humans surviving legionellosis exhibited a lower but highly significant proliferative response to Hsp60 (P < 0.0001 compared with controls by Mann-Whitney test) [8].
 

Chemical compound and disease context of Legionellosis

 

Biological context of Legionellosis

 

Anatomical context of Legionellosis

 

Gene context of Legionellosis

  • Nosocomial legionellosis, Paris, France. Evidence for transmission by potable water [1].
  • In five of six patients, the reactivity of their sera obtained at different times during legionellosis was qualitatively constant [17].
  • A strong correlation between high cTnI measurements and positive serologic values for legionellosis was found [18].
  • Legionellosis was common as judged by culture and serological testing (26 cases, 11%) and a further 22 cases were identified by polymerase chain reaction [19].
 

Analytical, diagnostic and therapeutic context of Legionellosis

References

  1. Nosocomial legionellosis, Paris, France. Evidence for transmission by potable water. Neill, M.A., Gorman, G.W., Gibert, C., Roussel, A., Hightower, A.W., McKinney, R.M., Broome, C.V. Am. J. Med. (1985) [Pubmed]
  2. Ciprofloxacin in the treatment of legionellosis in critically ill patients including those cases unresponsive to erythromycin. Unertl, K.E., Lenhart, F.P., Forst, H., Vogler, G., Wilm, V., Ehret, W., Ruckdeschel, G. Am. J. Med. (1989) [Pubmed]
  3. Legionella pneumophila pneumonia associated with acute respiratory distress syndrome successfully treated with imipenem. Mofredj, A., Baraka, D. Chemotherapy. (1997) [Pubmed]
  4. IL-10 enhances the growth of Legionella pneumophila in human mononuclear phagocytes and reverses the protective effect of IFN-gamma: differential responses of blood monocytes and alveolar macrophages. Park, D.R., Skerrett, S.J. J. Immunol. (1996) [Pubmed]
  5. Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis. Skerrett, S.J., Martin, T.R. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  6. Efficacy of SCH27899 in an animal model of Legionnaires' disease using immunocompromised A/J mice. Brieland, J.K., Loebenberg, D., Menzel, F., Hare, R.S. Antimicrob. Agents Chemother. (2000) [Pubmed]
  7. Antibody-mediated depletion of tumor necrosis factor-alpha impairs pulmonary host defenses to Legionella pneumophila. Skerrett, S.J., Bagby, G.J., Schmidt, R.A., Nelson, S. J. Infect. Dis. (1997) [Pubmed]
  8. Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60. Weeratna, R., Stamler, D.A., Edelstein, P.H., Ripley, M., Marrie, T., Hoskin, D., Hoffman, P.S. Infect. Immun. (1994) [Pubmed]
  9. Comparative efficacy of five antibiotics on experimental airborne legionellosis in guinea-pigs. Nowicki, M., Paucod, J.C., Bornstein, N., Meugnier, H., Isoard, P., Fleurette, J. J. Antimicrob. Chemother. (1988) [Pubmed]
  10. Retrospective examination of lung tissue specimens for the presence of Legionella organisms: comparison of an indirect fluorescent-antibody system with direct fluorescent-antibody testing. Brown, S.L., Bibb, W.F., McKinney, R.M. J. Clin. Microbiol. (1984) [Pubmed]
  11. Efficacy of spiramycin on experimental airborne legionellosis in guinea pigs. Nowicki, M., Paucod, J.C., Bornstein, N., Isoard, P., Fleurette, J. J. Antimicrob. Chemother. (1988) [Pubmed]
  12. Identification of Legionella pneumophila by latex agglutination. Sedgwick, A.K., Tilton, R.C. J. Clin. Microbiol. (1983) [Pubmed]
  13. Comparative in vitro activity and post-antibiotic effect of gemifloxacin against Legionella spp. Dubois, J., St-Pierre, C. J. Antimicrob. Chemother. (2000) [Pubmed]
  14. Changes in iron and transferrin levels and body temperature in experimental airborne legionellosis. Muller, D., Edwards, M.L., Smith, D.W. J. Infect. Dis. (1983) [Pubmed]
  15. Treatment of legionnaires' disease. Klein, N.C., Cunha, B.A. Seminars in respiratory infections. (1998) [Pubmed]
  16. Recombinant murine interferon-gamma reversibly activates rat alveolar macrophages to kill Legionella pneumophila. Skerrett, S.J., Martin, T.R. J. Infect. Dis. (1992) [Pubmed]
  17. Antigenic specificity of the antibody response in humans during legionellosis. Brown, A., Lema, M.W., Brown-Schlumpf, M.S. Infection (1986) [Pubmed]
  18. Heterophile antibodies produce spuriously elevated concentrations of cardiac Troponin I in patients with Legionella pneumophila. García-Mancebo, M.L., Agulló-Ortuño, M.T., Gimeno, J.R., Navarro-Martínez, M.D., Ruíz-Gómez, J., Noguera-Velasco, J.A. Clin. Biochem. (2005) [Pubmed]
  19. Legionella, Chlamydia pneumoniae and Mycoplasma infection in patients admitted to Christchurch Hospital with pneumonia. Chambers, S.T., Town, G.I., Neill, A.M., Frampton, C., Murdoch, D.R. N. Z. Med. J. (1999) [Pubmed]
  20. Legionella pneumophila serogroup 1 strain Paris: endemic distribution throughout France. Aurell, H., Etienne, J., Forey, F., Reyrolle, M., Girardo, P., Farge, P., Decludt, B., Campese, C., Vandenesch, F., Jarraud, S. J. Clin. Microbiol. (2003) [Pubmed]
  21. New concepts in the pulmonary disposition of antibiotics. Bergogne-Berezin, E. Pulmonary pharmacology. (1995) [Pubmed]
 
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