The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Tnp1  -  transition protein 1

Rattus norvegicus

Synonyms: STP-1, Spermatid nuclear transition protein 1, TP-1, Testis-specific basic protein
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Tnp1

  • Using a cDNA clone as probe, we have isolated the gene (Stp-1) coding for rat TP1 from a population of recombinant bacteriophage lambda [1].
  • Serial renin-angiotensin studies in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Transition from normal- to high-renin status during the established phase of spontaneous hypertension [2].
  • Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion [3].
 

Psychiatry related information on Tnp1

 

High impact information on Tnp1

 

Biological context of Tnp1

 

Anatomical context of Tnp1

  • Isolation of a cDNA clone for transition protein 1 (TP1), a major chromosomal protein of mammalian spermatids [14].
  • Cytoplasmic localization during storage and translation of the mRNAs of transition protein 1 and protamine 1, two translationally regulated transcripts of the mammalian testis [15].
  • The recent identification of high expression of the novel CRE-activating protein (CREM tau) in advanced testicular germ cells provided a stimulus to ask whether or not the TP1 CRE is functional [10].
  • TP1 mRNA contents of round spermatids incubated in media from Sertoli cells cultured in the presence of FSH and/or testosterone were two- to threefold higher than those of spermatids incubated in media from Sertoli cells cultured without hormones [16].
  • TH2B mRNAs appeared first in preleptotene spermatocytes (PL) on day 12 and in pachytene spermatocytes (PS) on day 18; p19 mRNAs were present in PS from day 18 onward, and TP1 and TP2 mRNAs were detected in round spermatids (RS) from day 32 onward [17].
 

Associations of Tnp1 with chemical compounds

  • The amounts of TP1 mRNAs in FSH- or FSH plus testosterone-treated cultures were higher than those of controls [16].
  • Identification of a functional cyclic adenosine 3',5'-monophosphate response element in the 5'-flanking region of the gene for transition protein 1 (TP1), a basic chromosomal protein of mammalian spermatids [10].
  • 3. Transition from the high energy state (state4) to the active respiration (state3) in mitochondria oxidizing 2-oxoglutarate or plamitoyl-L-carnitine causes an increase of the amount of the active form of pyruvate dehydrogenase due to the decrease of ATP/ADP ratio in the matrix [18].
  • Moreover, the absolute values of Transition Time Control Coefficients in glycolytic conditions are one order of magnitude bigger than in gluconeogenic conditions [19].
  • The inhibition on H3, TP1, TP3 and S1 was insignificant by gossypol [20].
 

Enzymatic interactions of Tnp1

 

Other interactions of Tnp1

  • Ratio of Flux Control coefficients of glucokinase over phosphofructokinase at 5 and 20 mM glucose concentration changes from 3.2 to 0.5, while the same ratio in the case of Transition Time Control Coefficients moves from 0.6 to 0.93 [19].
 

Analytical, diagnostic and therapeutic context of Tnp1

  • In PS-Sertoli cell cocultures, the ratios of p19:TP1 and TH2B:TP2 decreased dramatically during the second week of culture; this was due not only to a decrease in the levels of p19 and TH2B mRNAs but also to an enhancement in the relative amounts of TP1 and TP2 as compared to the amounts present on the first day of the coculture [22].
  • Expression of the testis-specific histone TH2B, the phosphoprotein p19, and the transition proteins TP1 and TP2, was localized in the rat testis and quantified, using in situ hybridization of their mRNAs with radiolabeled probes and image analysis [17].
  • Treatment with thymostimulin (TP-1), a partially purified thymic extract, reduced the intensity of the expression of iNOS protein in the liver after bile duct ligation [23].
  • The expression of differential stage-specific mRNAs, including those of the c-kit receptor proto-oncogene, meiotic heat-shock protein 70 gene, acrosin gene, and transition protein 1 gene, was analyzed by the reverse transcriptase-polymerase chain reaction during spermatogenesis [24].
  • Thirty rats were allotted to three groups: A, control, no transplantation (Tx); B, rats receiving an orthotopic SBA; C, similar SBA but with thymostimulin (TP-1) administered before Tx, aimed at increasing the intensity of and accelerating rejection [25].

References

  1. Nucleotide sequence of the Stp-1 gene coding for rat spermatid nuclear transition protein 1 (TP1): homology with protamine P1 and assignment of the mouse Stp-1 gene to chromosome 1. Heidaran, M.A., Kozak, C.A., Kistler, W.S. Gene (1989) [Pubmed]
  2. Serial renin-angiotensin studies in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Transition from normal- to high-renin status during the established phase of spontaneous hypertension. Bagby, S.P., McDonald, W.J., Mass, R.D. Hypertension (1979) [Pubmed]
  3. Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion. Gao, Q., Pan, H.Y., Xia, Q., Bruce, I. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2005) [Pubmed]
  4. Poly(A)+ ribonucleic acids are enriched in spermatocyte nuclei but not in chromatoid bodies in the rat testis. Morales, C.R., Hecht, N.B. Biol. Reprod. (1994) [Pubmed]
  5. Control analysis of transition times. Extension of analysis and matrix method. Cascante, M., Torres, N.V., Franco, R., Meléndez-Hevia, E., Canela, E.I. Mol. Cell. Biochem. (1991) [Pubmed]
  6. Purification and characterization of the rat spermatid basic nuclear protein TP4. Unni, E., Meistrich, M.L. J. Biol. Chem. (1992) [Pubmed]
  7. Transcriptional and translational control of the message for transition protein 1, a major chromosomal protein of mammalian spermatids. Heidaran, M.A., Kistler, W.S. J. Biol. Chem. (1987) [Pubmed]
  8. Lymphocytes bearing receptors for IgE. III. Transition of Fc gamma R(+) cells to Fc epsilon R(4) cells by IgE. Yodoi, J., Ishizaka, K. J. Immunol. (1979) [Pubmed]
  9. The amino acid sequence of a testis-specific basic protein that is associated with spermatogenesis. Kistler, W.S., Noyes, C., Hsu, R., Heinrikson, R.L. J. Biol. Chem. (1975) [Pubmed]
  10. Identification of a functional cyclic adenosine 3',5'-monophosphate response element in the 5'-flanking region of the gene for transition protein 1 (TP1), a basic chromosomal protein of mammalian spermatids. Kistler, M.K., Sassone-Corsi, P., Kistler, W.S. Biol. Reprod. (1994) [Pubmed]
  11. Physiological Ca2+ level and Ca2+-induced Permeability Transition Pore control protein phosphorylation in rat brain mitochondria. Azarashvili, T., Krestinina, O., Odinokova, I., Evtodienko, Y., Reiser, G. Cell Calcium (2003) [Pubmed]
  12. Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2. Luerssen, H., Mattei, M.G., Schröter, M., Grzeschik, K.H., Adham, I.M., Engel, W. Genomics (1990) [Pubmed]
  13. Genes for chromosomal proteins expressed before and after meiosis. Kistler, W.S., Heidaran, M.A., Cole, K.D., Kandala, J.C., Showman, R.M. Ann. N. Y. Acad. Sci. (1987) [Pubmed]
  14. Isolation of a cDNA clone for transition protein 1 (TP1), a major chromosomal protein of mammalian spermatids. Heidaran, M.A., Kistler, W.S. Gene (1987) [Pubmed]
  15. Cytoplasmic localization during storage and translation of the mRNAs of transition protein 1 and protamine 1, two translationally regulated transcripts of the mammalian testis. Morales, C.R., Kwon, Y.K., Hecht, N.B. J. Cell. Sci. (1991) [Pubmed]
  16. The effects of FSH and of testosterone on the completion of meiosis and the very early steps of spermiogenesis of the rat: an in vitro study. Vigier, M., Weiss, M., Perrard, M.H., Godet, M., Durand, P. J. Mol. Endocrinol. (2004) [Pubmed]
  17. Localization and quantitative expression of mRNAs encoding the testis-specific histone TH2B, the phosphoprotein p19, the transition proteins 1 and 2 during pubertal development and throughout the spermatogenic cycle of the rat. Marret, C., Avallet, O., Perrard-Sapori, M.H., Durand, P. Mol. Reprod. Dev. (1998) [Pubmed]
  18. Studies on the influence of fatty acids on pyruvate dehydrogenase interconversion in rat-liver mitochondria. Walajtys-Rode, E.I. Eur. J. Biochem. (1976) [Pubmed]
  19. Transition time control analysis of a glycolytic system under different glucose concentrations. Control of transition time versus control of flux. Torres, N.V., Meléndez-Hevia, E. Mol. Cell. Biochem. (1992) [Pubmed]
  20. The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. Fei, R.R., Teng, C.S. Contraception. (1988) [Pubmed]
  21. Specific mRNAs in Sertoli and germinal cells of testes from stage synchronized rats. Morales, C.R., Alcivar, A.A., Hecht, N.B., Griswold, M.D. Mol. Endocrinol. (1989) [Pubmed]
  22. Pre- and postmeiotic expression of male germ cell-specific genes throughout 2-week cocultures of rat germinal and Sertoli cells. Weiss, M., Vigier, M., Hue, D., Perrard-Sapori, M.H., Marret, C., Avallet, O., Durand, P. Biol. Reprod. (1997) [Pubmed]
  23. Expression of inducible nitric oxide synthase in the liver of bile duct-ligated Wistar rats with modulation by lymphomononuclear cells. Arriero, M.M., López-Farré, A., Fryeiro, O., Rodríguez-Feo, J.A., Velasco, S., García-Durán, M., Fortes, J., De La Pinta, J.C., Muñoz, L.E., Celdrán , A. Surgery (2001) [Pubmed]
  24. Overexpression of c-myc induces apoptosis at the prophase of meiosis of rat primary spermatocytes. Kodaira, K., Takahashi, R., Hirabayashi, M., Suzuki, T., Obinata, M., Ueda, M. Mol. Reprod. Dev. (1996) [Pubmed]
  25. Changes in blood lymphocyte populations in experimental bowel allograft rejection. Navarro-Zorraquino, M., Güemes, A., Lozano, R., Larrad, L., Morandeira, M.J., Salinas, J.C., Pastor, C. Transpl. Int. (1996) [Pubmed]
 
WikiGenes - Universities