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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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High impact information on Gravitation

  • The latter filaments differed from those in the low-speed pellet in that they could not be depolymerized by Ca2+ and could not be sedimented at low g forces even from Triton X-100 lysates of platelets that had been activated with thrombin [1].
  • Additionally, vertically grown arg1-2 roots appear to accumulate a greater amount of auxin in an expanded domain of the root cap compared with the wild type, and no detectable lateral auxin gradient develops across mutant root caps in response to gravistimulation [2].
  • We observed a transient 5-fold increase in inositol 1,4,5-trisphosphate (IP3) within 10 s of gravistimulation in the lower half of the pulvinus, indicating that the positional change was sensed immediately [3].
  • Our data indicate the involvement of IP3 and inositol phospholipids in both short- and long-term responses to gravistimulation [3].
  • Additionally, phosphatidylinositol 4-phosphate 5-kinase activity in the lower pulvinus half increased transiently within 10 min of gravistimulation, suggesting that the increased IP3 production was accompanied by an up-regulation of phosphatidylinositol 4, 5-bisphosphate biosynthesis [3].

Biological context of Gravitation


Anatomical context of Gravitation


Associations of Gravitation with chemical compounds

  • Seven day old etiolated pea epicotyls were loaded symmetrically with 3H-indole 3-acetic acid (IAA) or 45Ca2+, then subjected to 1.5 hours of 1g gravistimulation [14].
  • Also, after dark pretreatment, significant bending responses following hormone application were observed in vertical segments with or without added sucrose, while gravistimulation produced a response only if segments were given sucrose [15].
  • Gravistimulation increased ethylene production in both lower and upper halves of the stems with much higher levels observed in the lower half [16].
  • After ten days, they were centrifuged at gravities (g) of 1.3-27 for 24 h in a CO2 incubator [17].
  • The homogenous symmetric expression of the cytokinin-responsive promoter in vertical root caps rapidly changed within less than 30 min of gravistimulation into an asymmetrical activation pattern, visualized as a lateral, distinctly stained, concentrated spot on the new lower root side of the cap cells [18].

Gene context of Gravitation

  • AGR1 transcripts were localized to the root distal elongation zone, a region undergoing a curvature response upon gravistimulation [19].
  • Within 15 min of gravistimulation, total levels of transcripts coding for calreticulin and calmodulin were elevated 5-fold in maize pulvinus total RNA [10].
  • The transgenic roots were shown to have altered calcium sensitivity in controlling gravitropic response, a reduction in basipetal indole-3-acetic acid transport, and a delay in the asymmetric auxin-induced beta-glucuronidase expression with gravistimulation as compared to the controls [20].
  • X-ray diffraction patterns show that the vesicles are stable in the absence of myelin basic protein, even under high g-forces [21].
  • One of the ACS genes (Am-ACS3) was abundantly expressed in the bending zone cortex at the lower side of the stems within 2 h of gravistimulation [16].

Analytical, diagnostic and therapeutic context of Gravitation

  • Also, we examined the influence of different G forces and centrifugation times on the retention behavior of the platelets in citrated platelet-rich plasma (PRP) and whole blood (WB) [22].


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  2. ALTERED RESPONSE TO GRAVITY is a peripheral membrane protein that modulates gravity-induced cytoplasmic alkalinization and lateral auxin transport in plant statocytes. Boonsirichai, K., Sedbrook, J.C., Chen, R., Gilroy, S., Masson, P.H. Plant Cell (2003) [Pubmed]
  3. Transient and sustained increases in inositol 1,4,5-trisphosphate precede the differential growth response in gravistimulated maize pulvini. Perera, I.Y., Heilmann, I., Boss, W.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
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  6. An optimised protocol for the production of autologous serum eyedrops. Liu, L., Hartwig, D., Harloff, S., Herminghaus, P., Wedel, T., Geerling, G. Graefes Arch. Clin. Exp. Ophthalmol. (2005) [Pubmed]
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  11. The role of actin filaments in the gravitropic response of snapdragon flowering shoots. Friedman, H., Vos, J.W., Hepler, P.K., Meir, S., Halevy, A.H., Philosoph-Hadas, S. Planta (2003) [Pubmed]
  12. Methacholine sensitivity and cAMP protein kinase in tracheal smooth muscle. Jensen, A.D., Puckett, A.M., Rinard, G.A., Torphy, T.J., Mayer, S.E. J. Appl. Physiol. (1986) [Pubmed]
  13. Effect of estradiol and dihydrotestosterone on hypergravity-induced MAPK signaling and occludin expression in human umbilical vein endothelial cells. Sumanasekera, W.K., Zhao, L., Ivanova, M., Morgan, D.D., Noisin, E.L., Keynton, R.S., Klinge, C.M. Cell Tissue Res. (2006) [Pubmed]
  14. On the nature and origin of the calcium asymmetry arising during gravitropic response in etiolated pea epicotyls. Migliaccio, F., Galston, A.W. Plant Physiol. (1987) [Pubmed]
  15. Effect of dark pretreatment on the kinetics of response of barley pulvini to gravistimulation and hormones. Brock, T.G., Kaufman, P.B. Plant Physiol. (1988) [Pubmed]
  16. An auxin-responsive 1-aminocyclopropane-1-carboxylate synthase is responsible for differential ethylene production in gravistimulated Antirrhinum majus L. flower stems. Woltering, E.J., Balk, P.A., Nijenhuis-Devries, M.A., Faivre, M., Ruys, G., Somhorst, D., Philosoph-Hadas, S., Friedman, H. Planta (2005) [Pubmed]
  17. Stimulation of proteoglycan and DNA syntheses in chondrocytes by centrifugation. Inoue, H., Hiasa, K., Samma, Y., Nakamura, O., Sakuda, M., Iwamoto, M., Suzuki, F., Kato, Y. J. Dent. Res. (1990) [Pubmed]
  18. Role of cytokinin in the regulation of root gravitropism. Aloni, R., Langhans, M., Aloni, E., Ullrich, C.I. Planta (2004) [Pubmed]
  19. The arabidopsis thaliana AGRAVITROPIC 1 gene encodes a component of the polar-auxin-transport efflux carrier. Chen, R., Hilson, P., Sedbrook, J., Rosen, E., Caspar, T., Masson, P.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. A universal role for inositol 1,4,5-trisphosphate-mediated signaling in plant gravitropism. Perera, I.Y., Hung, C.Y., Brady, S., Muday, G.K., Boss, W.F. Plant Physiol. (2006) [Pubmed]
  21. Lipid/myelin basic protein multilayers. A model for the cytoplasmic space in central nervous system myelin. Sedzik, J., Blaurock, A.E., Höchli, M. J. Mol. Biol. (1984) [Pubmed]
  22. Adhesion, spreading, and aggregation of platelets in flowing blood and the reliability of the retention test Homburg. Krischek, B., Morgenstern, E., Mestres, P., Klinkhardt, U., Brannath, W., Wieding, U., Nemeh, A., Heinrich, W., Schenk, J., Wenzel, T., Wenzel, E. Semin. Thromb. Hemost. (2005) [Pubmed]
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