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MeSH Review

Hypergravity

 
 
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Disease relevance of Hypergravity

 

Psychiatry related information on Hypergravity

  • Exposure to the combination of -6 degrees HDBR, emotional stress, and hypergravity led to an elevation of plasma histamine and serotinin and a dramatic decrease in the concentration of prostaglandins E, F2-alpha, and erthropoietin [4].
 

High impact information on Hypergravity

  • To investigate the role of cochlear and vestibular function in central and physiological responses, we have examined the effects of increased gravity in wild-type mice and mice lacking the POU homeodomain transcription factor Brn-3.1 (Brn-3bPou4f3) [5].
  • Hypergravity stimulated not only lysyl oxidase mRNA expression but also increased enzyme activity and the sum of immature and mature cross-links [6].
  • Staurosporin inhibited the induction of c-fos by hypergravity almost completely at a concentration of 0.1 microM, but it inhibited the induction of egr-1 only partially [7].
  • Quantitative changes in mRNA expression of glutamate receptors in the rat peripheral and central vestibular systems following hypergravity [8].
  • It is suggested that the animals adapted to the hypergravity by enhancing the cerebellar inhibition of the vestibular nucleus neurons through activation of the NR1 and GluR2 receptors on the Purkinje cells in uvula/nodulus especially at the early phase following hypergravity [8].
 

Biological context of Hypergravity

 

Anatomical context of Hypergravity

 

Associations of Hypergravity with chemical compounds

  • PGE2 release depended on duration but not orientation of the hypergravity load [13].
  • Urinary excretion of LH and testosterone from male rats during exposure to increased gravity: post-spaceflight and centrifugation [16].
  • Lanthanum or gadolinium inhibited the hypergravity-induced increase in the pH of the apoplastic fluid in the epicotyls, which is involved in the processes of the suppression of xyloglucan breakdown due to hypergravity [17].
  • Metabolite profiling for analysis of yeast stress response during very high gravity ethanol fermentations [18].
  • Twelve seated subjects performed a rebreathing-breath-holding-expiration maneuver with a gas mixture containing O2 and He at normal (1 G) and moderately increased gravity (2 G); an anti-G suit was inflated to 85 mmHg in each condition [19].
 

Gene context of Hypergravity

 

Analytical, diagnostic and therapeutic context of Hypergravity

References

  1. Stimulation of cyclic GMP efflux in human melanocytes by hypergravity generated by centrifugal acceleration. Ivanova, K., Zadeh, N.H., Block, I., Das, P.K., Gerzer, R. Pigment Cell Res. (2004) [Pubmed]
  2. Effects of fracture trauma, estrone treatment, and 2-G environment on the epiphyseal cartilage zones of developing avian radii. Negulesco, J.A. Aviation, space, and environmental medicine. (1978) [Pubmed]
  3. Changes in food intake and growth rate in mice under hypergravity. Yuwaki, K., Okuno, M. Biol. Sci. Space (2003) [Pubmed]
  4. Effects of the 120 days of head-down bed rest on cytokine secretion and its in vitro modulation by glucocorticoids. Uchakin, P.N., Cubbage, M.L., Sams, C.F., Morukov, B.V., Larina, I.V., Bobrovnik, E.B. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (1998) [Pubmed]
  5. Evidence for vestibular regulation of autonomic functions in a mouse genetic model. Murakami, D.M., Erkman, L., Hermanson, O., Rosenfeld, M.G., Fuller, C.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts. Saito, M., Soshi, S., Fujii, K. J. Bone Miner. Res. (2003) [Pubmed]
  7. Induction of early response genes by hypergravity in cultured mouse osteoblastic cells (MC3T3-E1). Nose, K., Shibanuma, M. Exp. Cell Res. (1994) [Pubmed]
  8. Quantitative changes in mRNA expression of glutamate receptors in the rat peripheral and central vestibular systems following hypergravity. Uno, Y., Horii, A., Uno, A., Fuse, Y., Fukushima, M., Doi, K., Kubo, T. J. Neurochem. (2002) [Pubmed]
  9. Intrauterine fetal response to hypergravity by reduction of plasma prolactin levels in the rat. Megory, E., Oyama, J. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  10. Stimulation of DNA polymerase alpha by hypergravity generated by centrifugal acceleration. Takemura, M., Yoshida, S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  11. Hypergravity induces phosphorylation of p53 at serine 15, but not an expression of p53-downstream genes. Okaichi, K., Ide, M., Usui, A., Okumura, Y. J. Radiat. Res. (2004) [Pubmed]
  12. Stimulative effect of high-level hypergravity on differentiated functions of osteoblast-like cells. Kawashima, K., Shibata, R., Negishi, Y., Endo, H. Cell Struct. Funct. (1998) [Pubmed]
  13. Influence of increased mechanical loading by hypergravity on the microtubule cytoskeleton and prostaglandin E2 release in primary osteoblasts. Searby, N.D., Steele, C.R., Globus, R.K. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  14. Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear. Takumi, Y., Iijima, N., Suzuki, N., Oguchi, T., Ando, N., Hashimoto, M., Hara, H., Yamashita, H., Usami, S. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  15. Fos induction in the amygdala by vestibular information during hypergravity stimulation. Nakagawa, A., Uno, A., Horii, A., Kitahara, T., Kawamoto, M., Uno, Y., Fukushima, M., Nishiike, S., Takeda, N., Kubo, T. Brain Res. (2003) [Pubmed]
  16. Urinary excretion of LH and testosterone from male rats during exposure to increased gravity: post-spaceflight and centrifugation. Ortiz, R.M., Wade, C.E., Morey-Holton, E. Proc. Soc. Exp. Biol. Med. (2000) [Pubmed]
  17. Graviperception in growth inhibition of plant shoots under hypergravity conditions produced by centrifugation is independent of that in gravitropism and may involve mechanoreceptors. Soga, K., Wakabayashi, K., Kamisaka, S., Hoson, T. Planta (2004) [Pubmed]
  18. Metabolite profiling for analysis of yeast stress response during very high gravity ethanol fermentations. Devantier, R., Scheithauer, B., Villas-Bôas, S.G., Pedersen, S., Olsson, L. Biotechnol. Bioeng. (2005) [Pubmed]
  19. Effects of gravity and blood volume shifts on cardiogenic oscillations in respired gas. Montmerle, S., Linnarsson, D. J. Appl. Physiol. (2005) [Pubmed]
  20. Increase in expression level of alpha-tubulin gene in Arabidopsis seedlings under hypergravity conditions. Saito, Y., Soga, K., Wakabayashi, K., Hoson, T. Biol. Sci. Space (2003) [Pubmed]
  21. Modulation by hypergravity of extracellular matrix macromolecules in in vitro human dermal fibroblasts. Gaubin, Y., Pianezzi, B., Soleilhavoup, J.P., Croute, F. Biochim. Biophys. Acta (1995) [Pubmed]
  22. Hypergravity induces expression of cyclooxygenase-2 in the heart vessels. Oshima, M., Oshima, H., Taketo, M.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  23. Effects of hypergravity exposure on plasma oxytocin concentration in pregnant and lactating rat dams. Baer, L.A., Wade, C.E., Ronca, A.E. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2002) [Pubmed]
  24. Simulated hypergravity running increases skeletal and cardiovascular loads. Groppo, E.R., Eastlack, R.K., Mahar, A., Hargens, A.R., Pedowitz, R.A. Medicine and science in sports and exercise. (2005) [Pubmed]
  25. Antibody binding in altered gravity: implications for immunosorbent assay during space flight. Maule, J., Fogel, M., Steele, A., Wainwright, N., Pierson, D.L., McKay, D.S. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2003) [Pubmed]
  26. Hypergravity impairs angiogenic response of in vitro cultured human primary endothelial cells. Spisni, E., Bianco, M.C., Blasi, F., Santi, S., Riccio, M., Toni, M., Griffoni, C., Tomasi, V. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2002) [Pubmed]
 
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