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MeSH Review


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Disease relevance of Clubfoot


High impact information on Clubfoot

  • Patients with GDAP1 mutations displayed severe, early childhood-onset CMT neuropathy with prominent pes equinovarus deformity and impairment of hand muscles [6].
  • Lifetime ADHD/Traits in the orthopedic controls occurred exclusively in males with clubfoot (7/13; 54%) [7].
  • The risks of clubfoot and diaphragmatic hernia also increased as maternal age increased [8].
  • The present fetus had rhizomelic micromelia with absence of ossification in the humerus, radius, ulna, and cervical and upper thoracic vertebral bodies; coronal clefts in the ossified thoracic vertebral bodies; and talipes equinovarus [9].
  • A case control analysis, however, excluded a pathogenetic role for allylestrenol in the etiology of clubfoot and multiple congenital anomalies [10].

Chemical compound and disease context of Clubfoot


Anatomical context of Clubfoot


Gene context of Clubfoot


Analytical, diagnostic and therapeutic context of Clubfoot


  1. Pseudodiastrophic dysplasia: a distinct newborn skeletal dysplasia. Eteson, D.J., Beluffi, G., Burgio, G.R., Belloni, C., Lachman, R.S., Rimoin, D.L. J. Pediatr. (1986) [Pubmed]
  2. Cortical dysgenesis in 2 patients with chromosome 22q11 deletion. Bird, L.M., Scambler, P. Clin. Genet. (2000) [Pubmed]
  3. Opitz C trigonocephaly syndrome and midline brain anomalies. Zampino, G., Di Rocco, C., Butera, G., Balducci, F., Colosimo, C., Torrioli, M.G., Mastroiacovo, P. Am. J. Med. Genet. (1997) [Pubmed]
  4. Accurate detection of anomalies by routine ultrasonography in an indigent clinic population. Magriples, U., Copel, J.A. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  5. Evaluation of serial casting to correct equinovarus deformity of the ankle after acquired brain injury in adults. Singer, B.J., Jegasothy, G.M., Singer, K.P., Allison, G.T. Archives of physical medicine and rehabilitation. (2003) [Pubmed]
  6. Mutations in the ganglioside-induced differentiation-associated protein-1 (GDAP1) gene in intermediate type autosomal recessive Charcot-Marie-Tooth neuropathy. Senderek, J., Bergmann, C., Ramaekers, V.T., Nelis, E., Bernert, G., Makowski, A., Züchner, S., De Jonghe, P., Rudnik-Schöneborn, S., Zerres, K., Schröder, J.M. Brain (2003) [Pubmed]
  7. Attention deficit hyperactivity disorder and neurocognitive correlates after childhood stroke. Max, J.E., Mathews, K., Manes, F.F., Robertson, B.A., Fox, P.T., Lancaster, J.L., Lansing, A.E., Schatz, A., Collings, N. Journal of the International Neuropsychological Society : JINS. (2003) [Pubmed]
  8. Maternal age and malformations in singleton births. Hollier, L.M., Leveno, K.J., Kelly, M.A., MCIntire, D.D., Cunningham, F.G. Obstetrics and gynecology. (2000) [Pubmed]
  9. Variant of atelosteogenesis? Report of a 20-week fetus. Herzberg, A.J., Effmann, E.L., Bradford, W.D. Am. J. Med. Genet. (1988) [Pubmed]
  10. A case-control study to evaluate the risk of congenital anomalies as a result of allylestrenol therapy during pregnancy. Czeizel, A., Huiskes, N. Clinical therapeutics. (1988) [Pubmed]
  11. Fractional lengthening of the flexor tendons in clubfoot surgery. Atar, D., Lehman, W.B., Grant, A.D., Strongwater, A.M. Clin. Orthop. Relat. Res. (1991) [Pubmed]
  12. Two cases of glycine encephalopathy accompanied by pes equinovarus. Zenciroglu, A., Demirel, N., Yagmur Bas, A., Aydemir, C., Agildere, M., Kalkanoglu, S., Coskun, T. J. Child Neurol. (2005) [Pubmed]
  13. Intra-uterine growth retardation and limb deformities produced by neuromuscular blocking agents in the rat fetus. Shoro, A.A. J. Anat. (1977) [Pubmed]
  14. Update on new developments in the study of human teratogens. Shepard, T.H., Brent, R.L., Friedman, J.M., Jones, K.L., Miller, R.K., Moore, C.A., Polifka, J.E. Teratology (2002) [Pubmed]
  15. Plasma total homocysteine level in mothers of children with clubfoot. Karakurt, L., Yilmaz, E., Serin, E., Bektaş, B., Cikim, G., Gürsu, F. Journal of pediatric orthopedics. (2003) [Pubmed]
  16. Parent satisfaction comparing two bandage materials used during serial casting in infants. Coss, H.S., Hennrikus, W.L. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (1996) [Pubmed]
  17. Autosomal recessive multiple epiphyseal dysplasia with homozygosity for C653S in the DTDST gene: double-layer patella as a reliable sign. Mäkitie, O., Savarirayan, R., Bonafé, L., Robertson, S., Susic, M., Superti-Furga, A., Cole, W.G. Am. J. Med. Genet. A (2003) [Pubmed]
  18. Acetabulum pedis. Part II: Talocalcaneonavicular joint socket in clubfoot. Epeldegui, T., Delgado, E. Journal of pediatric orthopaedics. Part B / European Paediatric Orthopaedic Society, Pediatric Orthopaedic Society of North America. (1995) [Pubmed]
  19. Variation in CASP10 gene is associated with idiopathic talipes equinovarus. Heck, A.L., Bray, M.S., Scott, A., Blanton, S.H., Hecht, J.T. Journal of pediatric orthopedics. (2005) [Pubmed]
  20. Low back pain in persons with congenital club foot. Bjönness, T. Scandinavian journal of rehabilitation medicine. (1975) [Pubmed]
  21. Operative management of foot and ankle equinovarus associated with focal dystonia. Moore, T.J., Evans, W., Murray, D. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (1998) [Pubmed]
  22. Part 1. Congenital idiopathic clubfoot. Kyzer, S.P. Orthopaedic nursing / National Association of Orthopaedic Nurses. (1991) [Pubmed]
  23. Congenital diastasis of the inferior tibiofibular joint: a review of the literature and report of two cases. Garbarino, J.L., Clancy, M., Harcke, H.T., Steel, H.H., Cowell, H.R. Journal of pediatric orthopedics. (1985) [Pubmed]
  24. Administering caudal anesthesia at completion of clubfoot surgery does not affect postoperative use of narcotics. Black, M.D., Olney, B., Vitztum, C., Hassanein, K. Am J. Orthop. (2003) [Pubmed]
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