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Chemical Compound Review

Picryl chloride     2-chloro-1,3,5-trinitro- benzene

Synonyms: Tncb, Picrylchloride, NSC-1872, CCRIS 3098, AG-E-90558, ...
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Disease relevance of Picryl chloride


High impact information on Picryl chloride


Chemical compound and disease context of Picryl chloride


Biological context of Picryl chloride


Anatomical context of Picryl chloride


Associations of Picryl chloride with other chemical compounds

  • Early-acting DTH-initiating cells, and late-acting DTH-effector T cells were either from oxazolone (OX)-immune or picryl chloride (PCl)-immune CBA or BALB/c donors and were transferred to CBA or BALB/c recipients [25].
  • PC1-F initiates PC1 CS by mediating an early 2-h skin swelling reaction that is due to local release of the vasoactive amine serotonin (5-HT) by mast cells, and perhaps other 5-HT-containing cells [26].
  • The DNFB and PCl application in sensitizing doses to nonsensitized animals resulted in a cellular activation similar to that observed for 0.5% croton oil [27].
  • TNP-specific TABM in the sera of mice receiving an intracameral injection of TNP spleen cells, followed by contact sensitization with picrylchloride (PCl), were purified by affinity for TNP and were resolved by polyacrylamide gel electrophoresis and immunoblotting as M(r) 110,000 polypeptides [28].
  • Mice pretreated with cyclophosphamide have an increased ability to produce anti-trinitrophenyl cytotoxic T cells after painting with the contact sensitizing agent picryl chloride [29].

Gene context of Picryl chloride


Analytical, diagnostic and therapeutic context of Picryl chloride


  1. The I-J subregion codes for determinats on suppressor factor(s) which limit the contact sensitivity response to picryl chloride. Greene, M.I., Pierres, A., Dorf, M.E., Benacerraf, B. J. Exp. Med. (1977) [Pubmed]
  2. Anti-T-cell idiotype activity in serum of mice injected with syngeneic hapten-specific T-cell lines. Thomas, W.R., Mottram, P.L., Miller, J.F. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  3. Specific restoration of delayed hypersensitivity by lymphoid tissue extracts. Green, J.A., Williams, J., Levy, H.B. J. Immunol. (1977) [Pubmed]
  4. Cell-mediated immune responsiveness of patients with acute lymphocytic leukemia in remission. Oldham, R.K., Weiner, R.S., Mathé, G., Breard, J., Simmler, M.C., Carde, P., Herberman, R.B. Int. J. Cancer (1976) [Pubmed]
  5. Persistent interleukin-2 activity and molecular evidence for expression of lymphotoxin in the hapten-immune model for pulmonary interstitial fibrosis. Garcia, H., Salter-Cid, L., Stein-Streilein, J. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  6. Reaginic antibody produced in mice with contact sensitivity. Thomas, W.R., Asherson, G.L., Watkins, M.C. J. Exp. Med. (1976) [Pubmed]
  7. Peyer's patches are required for oral tolerance to proteins. Fujihashi, K., Dohi, T., Rennert, P.D., Yamamoto, M., Koga, T., Kiyono, H., McGhee, J.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Inhibition by interferon of delayed-type hypersensitivity in the mouse. De Maeyer, E., De Maeyer-Guignard, J., Vandeputte, M. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  9. Development of IFN-gamma-producing CD8+ gamma delta+ T lymphocytes and IL-2-producing CD4+ alpha beta+ T lymphocytes during contact sensitivity. Dieli, F., Asherson, G.L., Sireci, G., Dominici, R., Sciré, E., Salerno, A. J. Immunol. (1997) [Pubmed]
  10. Carrier-independent hapten recognition and promiscuous MHC restriction by CD4 T cells induced by trinitrophenylated peptides. Kohler, J., Hartmann, U., Grimm, R., Pflugfelder, U., Weltzien, H.U. J. Immunol. (1997) [Pubmed]
  11. Cyclophosphamide-induced blood and tissue eosinophilia in contact sensitivity: mechanism of hapten-induced eosinophil recruitment into the skin. Satoh, T., Chen, Q.J., Sasaki, G., Yokozeki, H., Katayama, I., Nishioka, K. Eur. J. Immunol. (1997) [Pubmed]
  12. Impairment of antigen-presenting cell function by ultraviolet radiation. II. Effect of in vitro ultraviolet irradiation on antigen-presenting cells. Fox, I.J., Sy, M.S., Benacerraf, B., Greene, M.I. Transplantation (1981) [Pubmed]
  13. Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption. Nishijima, T., Tokura, Y., Imokawa, G., Seo, N., Furukawa, F., Takigawa, M. J. Invest. Dermatol. (1997) [Pubmed]
  14. Suppression of contact sensitivity and cell-mediated lympholysis by oral administration of hapten is caused by different mechanisms. Gautam, S.C., Battisto, J.R. Cell. Immunol. (1983) [Pubmed]
  15. The expression of MHC class II (Ia) antigens on mouse keratinocytes following epicutaneous application of contact sensitizers and irritants. Stringer, C.P., Hicks, R., Botham, P.A. Br. J. Dermatol. (1991) [Pubmed]
  16. In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity. Sumi, K., Yokozeki, H., Wu, M.H., Satoh, T., Kaneda, Y., Takeda, K., Akira, S., Nishioka, K. Gene Ther. (2004) [Pubmed]
  17. Split unresponsiveness to the trinitrophenyl determinant. I. Manoeuvers which suppress either humoral or cell-mediated immune responses. Ptak, W., Rózycka, D. Eur. J. Immunol. (1977) [Pubmed]
  18. Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. Kölgen, W., van Steeg, H., van der Horst, G.T., Hoeijmakers, J.H., van Vloten, W.A., de Gruijl, F.R., Garssen, J. J. Invest. Dermatol. (2003) [Pubmed]
  19. The effect of progesterone, oestradiol and HCG on cell-mediated immunity in pregnant mice. Carter, J. J. Reprod. Fertil. (1976) [Pubmed]
  20. Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin. Chen, Y.P., Woods, G.M., Dandie, G.W., Muller, H.K. Immunol. Cell Biol. (1997) [Pubmed]
  21. H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization. Miller, S.D., Sy, M.S., Claman, H.N. J. Exp. Med. (1977) [Pubmed]
  22. A role for mast cells and the vasoactive amine serotonin in T cell-dependent immunity to tumors. Van Loveren, H., Den Otter, W., Meade, R., Terheggen, P.M., Askenase, P.W. J. Immunol. (1985) [Pubmed]
  23. Major histocompatibility complex regulation of interleukin-5 production in the mouse. Dieli, F., Sireci, G., Lio, D., Bonanno, C.T., Salerno, A. Eur. J. Immunol. (1993) [Pubmed]
  24. Induction of low zone tolerance to contact allergens in mice does not require functional Langerhans cells. Steinbrink, K., Kolde, G., Sorg, C., Macher, E. J. Invest. Dermatol. (1996) [Pubmed]
  25. Delayed-type hypersensitivity initiation by early-acting cells that are antigen mismatched or MHC incompatible with late-acting, delayed-type hypersensitivity effector T cells. Ptak, W., Herzog, W.R., Askenase, P.W. J. Immunol. (1991) [Pubmed]
  26. The antigen-binding T cell factor PCl-F sensitizes mast cells for in vitro release of serotonin. Comparison with monoclonal IgE antibody. Meade, R., Van Lovern, H., Parmentier, H., Iverson, G.M., Askenase, P.W. J. Immunol. (1988) [Pubmed]
  27. Different cellular reaction patterns of epidermal Langerhans cells after application of contact sensitizing, toxic, and tolerogenic compounds. A comparative ultrastructural and morphometric time-course analysis. Kolde, G., Knop, J. J. Invest. Dermatol. (1987) [Pubmed]
  28. Intracameral injection of antigen potentiates the production of antigen-specific T cell proteins in serum after the induction of delayed-type hypersensitivity. Hadjikouti, C.A., Wang, Y., O'Rourke, J., Cone, R.E. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  29. Suppressor T cells which block the induction of cytotoxic T cells in vivo. Tagart, V.B., Thomas, W.R., Asherson, G.L. Immunology (1978) [Pubmed]
  30. Activation of Lyt-1+ and Lyt-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction. Conta, B.S., Powell, M.B., Ruddle, N.H. J. Immunol. (1985) [Pubmed]
  31. Production of lymphotoxin, IFN-gamma and IFN-alpha, beta by murine T cell lines and clones. Conta, B.S., Powell, M.B., Ruddle, N.H. J. Immunol. (1983) [Pubmed]
  32. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity. Nakae, S., Naruse-Nakajima, C., Sudo, K., Horai, R., Asano, M., Iwakura, Y. Int. Immunol. (2001) [Pubmed]
  33. Kinetic profiles of sequential gene expressions for chemokines in mice with contact hypersensitivity. Mitsui, G., Mitsui, K., Hirano, T., Ohara, O., Kato, M., Niwano, Y. Immunol. Lett. (2003) [Pubmed]
  34. Modulation of age-related development of contact sensitivity in mice by adult thymectomy. Roupe, G. J. Invest. Dermatol. (1978) [Pubmed]
  35. Hair cycle-dependent changes in skin immune functions: anagen-associated depression of sensitization for contact hypersensitivity in mice. Hoffman, U., Tokura, Y., Nishijima, T., Takigawa, M., Paus, R. J. Invest. Dermatol. (1996) [Pubmed]
  36. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. Schwarzenberger, K., Udey, M.C. J. Invest. Dermatol. (1996) [Pubmed]
  37. Topical application of F991, an immunoglobulin free light chain antagonist, prevents development of contact sensitivity in mice. van Houwelingen, A.H., Kaczynska, K., Kraneveld, A.D., Kool, M., Nijkamp, F.P., Redegeld, F.A. Clin. Exp. Allergy (2007) [Pubmed]
  38. A role for neuropeptides in UVB-induced systemic immunosuppression. Garssen, J., Buckley, T.L., Van Loveren, H. Photochem. Photobiol. (1998) [Pubmed]
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