Disease relevance of heptadecanoic acid

• The results described in the literature of myocardial scintigraphy with radioiodinated heptadecanoic acid (IHDA) to detect coronary stenoses are contradictory [1].
• HDA tomoscintigraphy cannot replace TI-201 for the evaluation of regional coronary reserve in coronary heart disease [2].
• HDA tomography of the myocardium had an 86% sensitivity for myocardial infarcts (MIs) up to 4 wk old, and 83% for myocardial scars (MSs) [2].
• Metabolic myocardial imaging with 123I-labeled heptadecanoic acid in patients with angina pectoris [3].
• Myocardial scintigraphy with 123I-labelled heptadecanoic acid in patients with unstable angina pectoris [4].

High impact information on heptadecanoic acid

• Because of this observed difference in membrane "fluidity," we attempted modification of the plasma membrane fluidity by the incorporation of heptadecanoic acid into KB-3-1 and KCP-20 cell membranes [5].
• Clinical value of studies with radioiodinated heptadecanoic acid in patients with coronary artery disease [1].
• Kinetics of radioiodinated heptadecanoic acid and metabolites in the normal and ischaemic canine heart [6].
• In samples of normal and ischaemic myocardium the distribution of the radioactivity over free radioiodide, heptadecanoic acid and lipids was determined [6].
• Measurement of myocardial fatty acid metabolism by iodine-123 heptadecanoic acid kinetics [7].

Biological context of heptadecanoic acid

• Fractional amounts of HDA beta-oxidation, backdiffusion, and esterification were also similar [8].
• Early assessment of tissue viability with radioiodinated heptadecanoic acid in reperfused canine myocardium: comparison with thallium-201 [9].
• The use of grafts prelabeled by feeding the donor margaric acid indicated that total lack of fatty acid turnover, rather than selective metabolic processes, was responsible for the failure of some grafts from obese mice in lean mice to acquire the fatty acid composition of the perirenal adipose tissue of the host [10].
• The method used plasma extraction after addition of heptadecanoic acid as internal standard and methylation with diazomethane [11].

Anatomical context of heptadecanoic acid

• In normal myocardium the major component was free radioiodide, only a small percentage being heptadecanoic acid [6].
• We found that such treatment resulted in increased heptadecanoic acid content and increased fluidity in the plasma membranes of both cell types, and also resulted in increased cisplatin resistance in the KCP-20 cells [5].
• Subcutaneous fat had a higher content of heptadecanoic acid (17:0) than i.m. fat, and this increased with the increase in slaughter weight [12].
• Demonstration of the thoracic duct by 123I heptadecanoic acid. Report of a case [13].
• Growth of CHRC5 multidrug resistant cells in media enriched in a saturated C-17 fatty acid, heptadecanoic acid, resulted in these cells accumulating vinblastine at a rate and to an extent comparable to that of the parental cell line AB1 [14].

Associations of heptadecanoic acid with other chemical compounds

• Measurement of myocardial fatty acid metabolism by iodine-123 heptadecanoic acid kinetics [15].
• The amounts of fatty acids synthesized in deuterated water are determined by mass fragmentography by monitoring the intensities of m/e 77 and m/e 74 fragment ions using heptadecanoic acid as an internal standard [16].
• Scintigraphy with 17-iodo-123 heptadecanoic acid was performed to study free fatty acid kinetics in the normal human myocardium during control and glucose infusion (n = 9) [17].

Gene context of heptadecanoic acid

• By this method, seven kinds of free fatty acid (C6, C10, C12, C14, C16, C18 and C20) could be determined using margaric acid (C17) as an internal standard [18].
• The main fatty acyl residues are anteiso-branched heptadecanoic acid and the iso-branched fatty acids iso-17:0, iso-16:0, and iso-18:0, with the former species being predominant [19].
• In patients with MVP, a high incidence concerning abnormalities of accumulation and/or elimination of HDA occurred, namely accumulation defects in 31% and both prolonged and shortened elimination half-lives in 16% and 29%, respectively [20].

Analytical, diagnostic and therapeutic context of heptadecanoic acid

• After intravenous injection of radioiodinated heptadecanoic acid a high background activity disturbs direct determination of myocardial elimination rates [21].
• It is concluded that scintigraphy with radioiodinated heptadecanoic acid is an appropriate method to assess myocardial viability in patients with successful thrombolytic therapy [22].
• Twelve subjects with normal coronary arteries and normal ventriculogram served as a control group for the evaluation of elimination kinetics of HDA [20].
• METHODS: A series of post-exercise single-photon emission computed tomography (SPECT) measurements was performed after injection of 123I labelled heptadecanoic acid (HDA) [23].
• Using 123I-omega-heptadecanoic acid (HDA) and 201Tl, respectively, myocardial fatty acid metabolism and perfusion were studied in 51 symptomatic patients with mitral valve prolapse (MVP) as diagnosed by ventriculography, and no evidence of coronary artery disease [20].

References