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Chemical Compound Review

Methylumbelliferone     7-methoxychromen-2-one

Synonyms: Ayapanin, Herniarin, Herniarine, SPECTRUM210874, CHEMBL49732, ...
 
 
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Disease relevance of Methylumbelliferone

 

High impact information on Methylumbelliferone

 

Biological context of Methylumbelliferone

 

Anatomical context of Methylumbelliferone

 

Associations of Methylumbelliferone with other chemical compounds

 

Gene context of Methylumbelliferone

  • Progressive and irreversible inactivation of P-450(2), but not P-450(1) and rat P-448(2), was observed during the catalysis of 7-methoxycoumarin O-demethylation, and this inactivation was considerably prevented by inclusion of cytochrome b5 in the reconstituted system [19].
  • Incubation under paraffin oil in 0.05 microliter of substrate, followed by fluorescence measurements in 1-5 microliter with a microscope fluorometer, allows down to 10(-14) mol of methylumbelliferone, which is the end-product in many analyses of lysosomal enzymes, to be detected [20].

References

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  8. Identification of the major 4-methylumbelliferyl p-guanidinobenzoate-hydrolyzing plasma protein in cystic fibrosis: implication for intrauterine and heterozygote detection. Branchini, B.R., Salituro, G.M., Rosenstein, B.J. Pediatr. Res. (1983) [Pubmed]
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  12. Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital-inducible cytochrome P450s. Reen, R.K., Ramakanth, S., Wiebel, F.J., Jain, M.P., Singh, J. Anal. Biochem. (1991) [Pubmed]
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  14. Fluorescence detection of hydrolases with methylumbelliferone, naphthol and naphthol AS substrates using isoelectric focusing. Sinha, P.K., Gossrau, R. Histochem. J. (1984) [Pubmed]
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  17. Quantification of spiroether isomers and herniarin of different parts of Matricaria matricarioides and flowers of Chamaemelum nobile. Ma, C.M., Winsor, L., Daneshtalab, M. Phytochemical analysis : PCA (2007) [Pubmed]
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