The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Methylumbelliferone     7-methoxychromen-2-one

Synonyms: Ayapanin, Herniarin, Herniarine, SPECTRUM210874, CHEMBL49732, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Methylumbelliferone


High impact information on Methylumbelliferone


Biological context of Methylumbelliferone


Anatomical context of Methylumbelliferone


Associations of Methylumbelliferone with other chemical compounds


Gene context of Methylumbelliferone

  • Progressive and irreversible inactivation of P-450(2), but not P-450(1) and rat P-448(2), was observed during the catalysis of 7-methoxycoumarin O-demethylation, and this inactivation was considerably prevented by inclusion of cytochrome b5 in the reconstituted system [19].
  • Incubation under paraffin oil in 0.05 microliter of substrate, followed by fluorescence measurements in 1-5 microliter with a microscope fluorometer, allows down to 10(-14) mol of methylumbelliferone, which is the end-product in many analyses of lysosomal enzymes, to be detected [20].


  1. Development of an enzyme assay for rapid assessment of Escherichia coli in seawaters. Caruso, G., Crisafi, E., Mancuso, M. J. Appl. Microbiol. (2002) [Pubmed]
  2. A single-tube confirmatory test for E. coli using brilliant green mannitol methylumbelliferyl-beta-d-glucuronide tryptophane tryptone broth (BMMTT-medium). Schubert, R.H., Wahlig, M. Zentralblatt für Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine. (1989) [Pubmed]
  3. Stimulatory effect of cigarette smoke on the metabolism and covalent binding of benzo(a)pyrene in the trachea of the rat. Simberg, N., Uotila, P. Int. J. Cancer (1978) [Pubmed]
  4. Chitinase B of "Microbulbifer degradans" 2-40 contains two catalytic domains with different chitinolytic activities. Howard, M.B., Ekborg, N.A., Taylor, L.E., Weiner, R.M., Hutcheson, S.W. J. Bacteriol. (2004) [Pubmed]
  5. Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats. Omar H el-D, n.u.l.l., Sanders, R.A., Watkins, J.B. Biochem. Pharmacol. (1996) [Pubmed]
  6. Use of 7-alkoxyphenoxazones, 7-alkoxycoumarins and 7-alkoxyquinolines as fluorescent substrates for rainbow trout hepatic microsomes after treatment with various inducers. Haasch, M.L., Graf, W.K., Quardokus, E.M., Mayer, R.T., Lech, J.J. Biochem. Pharmacol. (1994) [Pubmed]
  7. A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases. Knight, C.G., Willenbrock, F., Murphy, G. FEBS Lett. (1992) [Pubmed]
  8. Identification of the major 4-methylumbelliferyl p-guanidinobenzoate-hydrolyzing plasma protein in cystic fibrosis: implication for intrauterine and heterozygote detection. Branchini, B.R., Salituro, G.M., Rosenstein, B.J. Pediatr. Res. (1983) [Pubmed]
  9. Quantitation of the delivery of liposome contents into plant protoplasts. Cutler, A.J., Constabel, F., Kurz, W.G., Shargool, P.D. Anal. Biochem. (1984) [Pubmed]
  10. 7-Ethoxycoumarin O-deethylation and methylumbelliferone conjugation in isolated fetal and adult bovine hepatocytes. Soulinna, E.M., Winberg, A.M. Drug Metab. Dispos. (1985) [Pubmed]
  11. Sialidosis type 2 (acid neuraminidase deficiency): clinical and biochemical features of a further case. Winter, R.M., Swallow, D.M., Baraitser, M., Purkiss, P. Clin. Genet. (1980) [Pubmed]
  12. Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital-inducible cytochrome P450s. Reen, R.K., Ramakanth, S., Wiebel, F.J., Jain, M.P., Singh, J. Anal. Biochem. (1991) [Pubmed]
  13. Differentiation of cytochrome P-450 inducers on the basis of 7-alkoxycoumarin O-dealkylase activities. Fry, J.R., Garle, M.J., Lal, K. Xenobiotica (1992) [Pubmed]
  14. Fluorescence detection of hydrolases with methylumbelliferone, naphthol and naphthol AS substrates using isoelectric focusing. Sinha, P.K., Gossrau, R. Histochem. J. (1984) [Pubmed]
  15. Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. Oliva, A., Meepagala, K.M., Wedge, D.E., Harries, D., Hale, A.L., Aliotta, G., Duke, S.O. J. Agric. Food Chem. (2003) [Pubmed]
  16. Alkamides from Artemisia dracunculus. Saadali, B., Boriky, D., Blaghen, M., Vanhaelen, M., Talbi, M. Phytochemistry (2001) [Pubmed]
  17. Quantification of spiroether isomers and herniarin of different parts of Matricaria matricarioides and flowers of Chamaemelum nobile. Ma, C.M., Winsor, L., Daneshtalab, M. Phytochemical analysis : PCA (2007) [Pubmed]
  18. Inhibition of respiratory burst in human neutrophils and lipoxygenase enzyme by compounds from Haloxylon griffithii. Choudhary, M.I., Jalil, S., Israr, M. Phytotherapy research : PTR. (2006) [Pubmed]
  19. Purification and characterization of cytochrome P-450 with high affinity for 7-alkoxycoumarins. Komori, M., Imai, Y., Sato, R. J. Biochem. (1984) [Pubmed]
  20. Quantitative cytochemical analysis of (single) cultured cells. Galjaard, H. Ciba Found. Symp. (1979) [Pubmed]
WikiGenes - Universities