The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cbs  -  cystathionine beta synthase

Rattus norvegicus

Synonyms: Beta-thionase, Cystathionine beta-synthase, Hemoprotein H-450, Serine sulfhydrase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cbs


High impact information on Cbs


Biological context of Cbs


Anatomical context of Cbs


Associations of Cbs with chemical compounds


Other interactions of Cbs


Analytical, diagnostic and therapeutic context of Cbs


  1. Hormonal regulation of cystathionine beta-synthase expression in liver. Ratnam, S., Maclean, K.N., Jacobs, R.L., Brosnan, M.E., Kraus, J.P., Brosnan, J.T. J. Biol. Chem. (2002) [Pubmed]
  2. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. Martinez, M., Cuskelly, G.J., Williamson, J., Toth, J.P., Gregory, J.F. J. Nutr. (2000) [Pubmed]
  3. Increasing levels of dietary homocystine with carotid endarterectomy produced proportionate increases in plasma homocysteine and intimal hyperplasia. Southern, F., Eidt, J., Drouilhet, J., Mukunyadzi, P., Williams, D.K., Cruz, C., Wang, Y.F., Poirier, L.A., Brown, A.T., Moursi, M.M. Atherosclerosis (2001) [Pubmed]
  4. Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria. Streck, E.L., Delwing, D., Tagliari, B., Matté, C., Wannmacher, C.M., Wajner, M., Wyse, A.T. Neurochem. Int. (2003) [Pubmed]
  5. Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats. Blaise, S., Alberto, J.M., Nédélec, E., Ayav, A., Pourié, G., Bronowicki, J.P., Guéant, J.L., Daval, J.L. Pediatr. Res. (2005) [Pubmed]
  6. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. Nieman, K.M., Rowling, M.J., Garrow, T.A., Schalinske, K.L. J. Biol. Chem. (2004) [Pubmed]
  7. Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver. Jacobs, R.L., Stead, L.M., Brosnan, M.E., Brosnan, J.T. J. Biol. Chem. (2001) [Pubmed]
  8. Rat cystathionine beta-synthase. Gene organization and alternative splicing. Swaroop, M., Bradley, K., Ohura, T., Tahara, T., Roper, M.D., Rosenberg, L.E., Kraus, J.P. J. Biol. Chem. (1992) [Pubmed]
  9. Molecular cloning and sequence analysis of cDNA coding for rat liver hemoprotein H-450. Ishihara, S., Morohashi, K., Sadano, H., Kawabata, S., Gotoh, O., Omura, T. J. Biochem. (1990) [Pubmed]
  10. Cysteine metabolism in the cestode Hymenolepis diminuta. Gomez-Bautista, M., Barrett, J. Parasitology (1988) [Pubmed]
  11. Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes. Sugiura, Y., Kashiba, M., Maruyama, K., Hoshikawa, K., Sasaki, R., Saito, K., Kimura, H., Goda, N., Suematsu, M. Antioxid. Redox Signal. (2005) [Pubmed]
  12. Development of methionine synthase, cystathionine-beta-synthase and S-adenosyl-homocysteine hydrolase during gestation in rats. VanAerts, L.A., Poirot, C.M., Herberts, C.A., Blom, H.J., De Abreu, R.A., Trijbels, J.M., Eskes, T.K., Peereboom-Stegeman, J.H., Noordhoek, J. J. Reprod. Fertil. (1995) [Pubmed]
  13. Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels. Distrutti, E., Sediari, L., Mencarelli, A., Renga, B., Orlandi, S., Antonelli, E., Roviezzo, F., Morelli, A., Cirino, G., Wallace, J.L., Fiorucci, S. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  14. Contents of cystathionine and taurine in various cerebellar regions of DL-propargylglycine-treated rats. Kodama, H., Sasaki, K., Mizobuchi, N., Kikuchi, R. J. Neurochem. (1988) [Pubmed]
  15. Enzymatic synthesis of selenocysteine in rat liver. Esaki, N., Nakamura, T., Tanaka, H., Suzuki, T., Morino, Y., Soda, K. Biochemistry (1981) [Pubmed]
  16. Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. Lima, C.P., Davis, S.R., Mackey, A.D., Scheer, J.B., Williamson, J., Gregory, J.F. J. Nutr. (2006) [Pubmed]
  17. Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes. Rao, A.M., Drake, M.R., Stipanuk, M.H. J. Nutr. (1990) [Pubmed]
  18. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. Finkelstein, J.D., Martin, J.J. J. Biol. Chem. (1984) [Pubmed]
  19. Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Miller, J.W., Nadeau, M.R., Smith, J., Smith, D., Selhub, J. Biochem. J. (1994) [Pubmed]
  20. Content of sulfur amino acids and vitamin B6 and related enzyme activities in rats with chronic renal failure fed a high methionine diet. Asagi, K., Nakayama, M., Kobayashi, M., Awata, S., Nakayama, K., Kodama, H. Nephron (1996) [Pubmed]
  21. Effect of D,L-propargylglycine on cystathionine metabolism in rats. Awata, S., Nakayama, K., Kodama, H. Biochem. Int. (1984) [Pubmed]
  22. Plasma homocysteine measurements after carotid artery manipulation and clamping in a rat CEA model. Brown, A.T., Chen, H., Davis, J.A., Qureshi, I., Cruz, C.P., Poirier, L.A., Eidt, J.F., Moursi, M.M. J. Vasc. Surg. (2004) [Pubmed]
WikiGenes - Universities