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Gene Review

Cth  -  cystathionine gamma-lyase

Rattus norvegicus

Synonyms: Cystathionine gamma-lyase, Cysteine-protein sulfhydrase, Gamma-cystathionase, PRB-RA, Probasin-related antigen
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Disease relevance of Cth


High impact information on Cth


Chemical compound and disease context of Cth


Biological context of Cth


Anatomical context of Cth


Associations of Cth with chemical compounds


Physical interactions of Cth


Other interactions of Cth


Analytical, diagnostic and therapeutic context of Cth


  1. Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes. Erickson, P.F., Maxwell, I.H., Su, L.J., Baumann, M., Glode, L.M. Biochem. J. (1990) [Pubmed]
  2. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Collin, M., Anuar, F.B., Murch, O., Bhatia, M., Moore, P.K., Thiemermann, C. Br. J. Pharmacol. (2005) [Pubmed]
  3. The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis. Fiorucci, S., Antonelli, E., Mencarelli, A., Orlandi, S., Renga, B., Rizzo, G., Distrutti, E., Shah, V., Morelli, A. Hepatology (2005) [Pubmed]
  4. Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension. Yanfei, W., Lin, S., Junbao, D., Chaoshu, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Yan, H., Du, J., Tang, C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Serviddio, G., Pereda, J., Pallardó, F.V., Carretero, J., Borras, C., Cutrin, J., Vendemiale, G., Poli, G., Viña, J., Sastre, J. Hepatology (2004) [Pubmed]
  7. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. Jacobs, R.L., House, J.D., Brosnan, M.E., Brosnan, J.T. Diabetes (1998) [Pubmed]
  8. Identification of probasin-related antigen as cystathionine gamma-lyase by molecular cloning. Nishi, N., Tanabe, H., Oya, H., Urushihara, M., Miyanaka, H., Wada, F. J. Biol. Chem. (1994) [Pubmed]
  9. Insight into the active site of Streptomyces cystathionine gamma-lyase based on the results of studies on its substrate specificity. Kanzaki, H., Nagasawa, T., Yamada, H. Biochim. Biophys. Acta (1987) [Pubmed]
  10. Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis. Sastre, J., Martín, J.A., Gómez-Cabrera, M.C., Pereda, J., Borrás, C., Pallardó, F.V., Viña, J. Free Radic. Biol. Med. (2005) [Pubmed]
  11. Cysteine metabolism in the cestode Hymenolepis diminuta. Gomez-Bautista, M., Barrett, J. Parasitology (1988) [Pubmed]
  12. Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes. Rao, A.M., Drake, M.R., Stipanuk, M.H. J. Nutr. (1990) [Pubmed]
  13. Methionine adenosyltransferase, cystathionine beta-synthase and cystathionine gamma-lyase activity of rat liver subcellular particles, human blood cells and mixed white cells from rat bone marrow. Allsop, J., Watts, R.W. Clinical science and molecular medicine. Supplement. (1975) [Pubmed]
  14. Effect of L-propargylglycine on metabolism of sulfur-containing amino acids in pregnant rats and their fetuses. Sasaki, K., Awata, S., Kodama, H. Biochem. Int. (1985) [Pubmed]
  15. Enzymatic synthesis of selenocysteine in rat liver. Esaki, N., Nakamura, T., Tanaka, H., Suzuki, T., Morino, Y., Soda, K. Biochemistry (1981) [Pubmed]
  16. Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. Lima, C.P., Davis, S.R., Mackey, A.D., Scheer, J.B., Williamson, J., Gregory, J.F. J. Nutr. (2006) [Pubmed]
  17. Changes in cystathionine gamma-lyase in various regions of rat brain during development. Awata, S., Nakayama, K., Suzuki, I., Sugahara, K., Kodama, H. Biochem. Mol. Biol. Int. (1995) [Pubmed]
  18. A cystine-dependent inactivator of tyrosine aminotransferase co-purifies with gamma-cystathionase (cystine desulfurase). Hargrove, J.L., Wichman, R.D. J. Biol. Chem. (1987) [Pubmed]
  19. Unusual metabolism of sulfur-containing amino acids in rats treated with DL-propargylglycine. Kodama, H., Mikasa, H., Sasaki, K., Awata, S., Nakayama, K. Arch. Biochem. Biophys. (1983) [Pubmed]
  20. Experimental diabetes increases the formation of sulfane by transsulfuration and inactivation of tyrosine aminotransferase in cytosols from rat liver. Hargrove, J.L., Trotter, J.F., Ashline, H.C., Krishnamurti, P.V. Metab. Clin. Exp. (1989) [Pubmed]
  21. Effect of dietary glycine on methionine metabolism in rats fed a high-methionine diet. Sugiyama, K., Kushima, Y., Muramatsu, K. J. Nutr. Sci. Vitaminol. (1987) [Pubmed]
  22. L-cysteine metabolism in guinea pig and rat tissues. Wróbel, M., Ubuka, T., Yao, W.B., Abe, T. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1997) [Pubmed]
  23. Content of sulfur amino acids and vitamin B6 and related enzyme activities in rats with chronic renal failure fed a high methionine diet. Asagi, K., Nakayama, M., Kobayashi, M., Awata, S., Nakayama, K., Kodama, H. Nephron (1996) [Pubmed]
  24. Effect of D,L-propargylglycine on cystathionine metabolism in rats. Awata, S., Nakayama, K., Kodama, H. Biochem. Int. (1984) [Pubmed]
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