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Chemical Compound Review

ACMC-1BPHP     1,1-dimethylurea

Synonyms: ANW-33389, HSDB 4273, NSC-33603, NSC33603, KB-09878, ...
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Disease relevance of NSC33603

  • Instillation of dimethylurea, superoxide dismutase, or heat-inactivated catalase did not prevent lung edema formation [1].

High impact information on NSC33603


Biological context of NSC33603

  • The light minus dark difference spectrum and the kinetics of the indicator pigment C-550 have been measured at room temperature in isolate, envelope-free chloroplasts in the presence of 3-(3' ,4'-dichlorophenyl)-1,1-dimethylurea (DCMU) [7].
  • Studies with hydrolysis products of MIC showed that relatively large doses of methylamine (MA) and dimethylurea (DMU) (i.v.) produced cardiovascular depressant effects, without affecting the LBI & TBR [8].

Anatomical context of NSC33603


Gene context of NSC33603

  • An artificial aging procedure was also performed by passing a potassium phosphate mobile phase buffered at pH 7.0 through C18 50 mm x 3.9 mm dimethylurea columns [11].
  • However, the beta-CH2, and delta-CO2- groups of glu 212 in Rp. viridis are located in the corresponding region of D 1 occupied by the dimethylurea moiety of the inhibitor in our model of its binding to D 1 [12].

Analytical, diagnostic and therapeutic context of NSC33603

  • Chromatographic evaluations of a C18 dimethylurea phase in 150 mm x 3.9 mm HPLC columns were performed using the Tanaka and Engelhardt test mixtures [11].


  1. Eugenol causes oxidant-mediated edema in isolated perfused rabbit lungs. McDonald, J.W., Heffner, J.E. Am. Rev. Respir. Dis. (1991) [Pubmed]
  2. Association of glycolate oxidation with photosynthetic electron transport in plant and algal chloroplasts. Goyal, A., Tolbert, N.E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Photosynthetic control of the plasma membrane H+-ATPase in Vallisneria leaves. I. Regulation of activity during light-induced membrane hyperpolarization. Harada, A., Okazaki, Y., Takagi, S. Planta (2002) [Pubmed]
  4. Novel cardiac protective effects of urea: from shark to rat. Wang, X., Wu, L., Aouffen, M., Mateescu, M.A., Nadeau, R., Wang, R. Br. J. Pharmacol. (1999) [Pubmed]
  5. Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage. Trush, M.A., Mimnaugh, E.G., Ginsburg, E., Gram, T.E. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  6. Effects of the differentiating agents (inducers) dimethylacetamide, di- and tetramethylurea on epidermal tumor promotion by retinyl (vitamin A) acetate and croton oil in hamster cheek pouch. McGaughey, C., Jensen, J.L. Oncology (1980) [Pubmed]
  7. The kinetic relationship between the C-550 absorbance change, the reduction of Q(delta A320) and the variable fluorescence yield change in chloroplasts at room temperature. Melis, A., Schreiber, U. Biochim. Biophys. Acta (1979) [Pubmed]
  8. Non-specific cardiovascular depressant effect of methyl isocyanate (MIC) in rats. Kumar, P., Sachan, A.S., Pant, S.C., Vijayaraghavan, R., Srivastava, R.K. The Journal of toxicological sciences. (1989) [Pubmed]
  9. Transepithelial fluid shift generated by osmolarity gradients in unstimulated perfused rat submandibular glands. Nakahari, T., Yoshida, H., Imai, Y. Exp. Physiol. (1996) [Pubmed]
  10. The light dependent uptake of N-methylphenazinium cations by the thylakoids of isolated chloroplasts. Homann, P.H. Biochim. Biophys. Acta (1977) [Pubmed]
  11. Chromatographic and column stability at pH 7 of a C18 dimethylurea polar stationary phase. Silva, C.R., Collins, C.H., Jardim, I.C., Airoldi, C. Journal of chromatography. A. (2004) [Pubmed]
  12. Molecular modelling studies on the binding of phenylurea inhibitors to the D 1 protein of photosystem II. Bowyer, J., Hilton, M., Whitelegge, J., Jewess, P., Camilleri, P., Crofts, A., Robinson, H. Z. Naturforsch., C, J. Biosci. (1990) [Pubmed]
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