Disease relevance of NSC33603

• Instillation of dimethylurea, superoxide dismutase, or heat-inactivated catalase did not prevent lung edema formation [1].

High impact information on NSC33603

• Glycolate oxidation was assayed with 3-(3,4)-dichlorophenyl)-1,1-dimethylurea (DCMU) as oxygen uptake in the presence of MV at a rate of 9 mol per mg of chlorophyll per h [2].
• Although 3-(3',4'-dichlorophenyl)-1,1-dimethylurea (DCMU), an inhibitor of photosynthetic electron transport, did not affect the membrane potential in darkness, it completely inhibited the light-induced membrane hyperpolarization [3].
• 5. Urea derivatives as hydroxyurea, dimethylurea, and thiourea had antioxidant cardioprotective effect against the electrolysis-induced cardiac dysfunction of rat heart, but were not as effective as urea in suppressing the post-ischaemia reperfusion injury [4].
• Bleomycin-dependent DNA chain breakage catalyzed by rat lung microsomes and NADPH was significantly inhibited by the reactive oxygen scavengers superoxide dismutase and dimethylurea and by the metal chelator EDTA [5].
• The cell-differentiating agents (inducers) dimethylacetamide, dimethylurea and tetramethylurea significantly lowered the yields and/or incidences of total tumors, benign plaques, benign hyperkeratotic lesions and advanced tumors promoted by retinyl acetate or croton oil after initiation by 7,12-dimethylbenz(a)anthracene [6].

Biological context of NSC33603

• The light minus dark difference spectrum and the kinetics of the indicator pigment C-550 have been measured at room temperature in isolate, envelope-free chloroplasts in the presence of 3-(3' ,4'-dichlorophenyl)-1,1-dimethylurea (DCMU) [7].
• Studies with hydrolysis products of MIC showed that relatively large doses of methylamine (MA) and dimethylurea (DMU) (i.v.) produced cardiovascular depressant effects, without affecting the LBI & TBR [8].

Anatomical context of NSC33603

• To estimate the effective pore radius of the epithelium, non-electrolyte solutions (urea, dimethylurea, diethylurea, mannitol, sucrose and maltotriose) were also used as luminal solutions [9].
• At pH 7.5, the thylakoids of DCMU poisoned pokeweed chloroplasts are able to hold at least 6 MP+/chlorophyll [10].
• It is proposed that, in the presence of MP+, the light reaction of Photosystem I in DCMU-inhibited chloroplasts causes a conformational change of the membranes which exposes nucleophilic sites inside the thylakoids [10].

Gene context of NSC33603

• An artificial aging procedure was also performed by passing a potassium phosphate mobile phase buffered at pH 7.0 through C18 50 mm x 3.9 mm dimethylurea columns [11].
• However, the beta-CH2, and delta-CO2- groups of glu 212 in Rp. viridis are located in the corresponding region of D 1 occupied by the dimethylurea moiety of the inhibitor in our model of its binding to D 1 [12].

Analytical, diagnostic and therapeutic context of NSC33603

• Chromatographic evaluations of a C18 dimethylurea phase in 150 mm x 3.9 mm HPLC columns were performed using the Tanaka and Engelhardt test mixtures [11].

References