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Chemical Compound Review

CHEMBL78630     N-[4-(3-aminopropylamino) butyl]ethanamide

Synonyms: KBioGR_002466, KBioSS_002473, CHEBI:27911, HMDB02189, AC1Q5PCW, ...
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Disease relevance of C01029


High impact information on C01029


Biological context of C01029


Anatomical context of C01029


Associations of C01029 with other chemical compounds


Gene context of C01029

  • In contrast, 24 h exposure to 10 mM sodium butyrate produced no change in N8-acetylspermidine levels and an increase in the acetylation level of histones H4 and H2B [15].
  • In these amoeba a considerable polyamine oxidase activity has been found, which acts on N8-acetylspermidine, but not on free polyamines [21].

Analytical, diagnostic and therapeutic context of C01029


  1. Polyamine metabolism II: N-(Monoaminoalkyl)- and N-(polyaminoalkyl)acetamides in human urine. Abdel-Monem, M.M., Ohno, K. Journal of pharmaceutical sciences. (1977) [Pubmed]
  2. Polyamine excretion in depleted patients with gastrointestinal malignancy: effect of perioperative nutrition and tumor removal. Pöyhönen, M.J., Takala, J.A., Pitkänen, O., Kari, A., Alhava, E., Alakuijala, L.A., Eloranta, T.O. JPEN. Journal of parenteral and enteral nutrition. (1992) [Pubmed]
  3. Urinary N1-acetylspermidine and N8-acetylspermidine excretion in normal humans and in patients with colorectal cancer. O'Brien, B.L., Hankewych, M., McCormick, D., Jacoby, R., Brasitus, T.A., Halline, A.G. Dig. Dis. Sci. (1995) [Pubmed]
  4. Spermidine acetylation in N1 and N8 position in rat brain and in N-ethyl-N-nitrosourea-induced gliomas. Sessa, A., Broglia, E., Terreni, M.R., Perin, A. Cancer Lett. (1994) [Pubmed]
  5. 1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels and spermidine N1-acetyltransferase activity in rat colonic mucosa. Halline, A.G., Dudeja, P.K., Brasitus, T.A. Cancer Res. (1989) [Pubmed]
  6. Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion. Pöyhönen, M.J., Uusitalo, U.M., Kari, A., Takala, J.A., Alakuijala, L.A., Eloranta, T.O. Am. J. Clin. Nutr. (1990) [Pubmed]
  7. Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. Woolridge, D.P., Martinez, J.D., Stringer, D.E., Gerner, E.W. Biochem. J. (1999) [Pubmed]
  8. Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli. Ignatenko, N.A., Fish, J.L., Shassetz, L.R., Woolridge, D.P., Gerner, E.W. Biochem. J. (1996) [Pubmed]
  9. Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds. Pegg, A.E., Pakala, R., Bergeron, R.J. Biochem. J. (1990) [Pubmed]
  10. Effect of N8-acetylspermidine deacetylase inhibition on the growth of L1210 cells. Wang, Z., Fries, D., Blankenship, J. Biochem. Pharmacol. (1999) [Pubmed]
  11. Immunoelectron microscopy study of polyamines using a newly prepared monoclonal antibody against spermidine: use of a mixture of glutaraldehyde and paraformaldehyde as a cross-linking agent in the preparation of the antigen. Tanabe, T., Shin, M., Fujiwara, K. J. Biochem. (2004) [Pubmed]
  12. UV-induced changes in urinary polyamine excretion in the mouse. Seiler, N., Richards, W., Knödgen, B. Arch. Dermatol. Res. (1981) [Pubmed]
  13. Thermal denaturation of mononucleosomes in the presence of spermine, spermidine, N1-acetylspermidine, N8-acetylspermidine or putrescine: implications for chromosome structure. Blankenship, J.W., Morgan, J.E., Matthews, H.R. Mol. Biol. Rep. (1987) [Pubmed]
  14. Differentiation of PC12 cells induced by N8-acetylspermidine and by N8-acetylspermidine deacetylase inhibition. Mudumba, S., Menezes, A., Fries, D., Blankenship, J. Biochem. Pharmacol. (2002) [Pubmed]
  15. A selective inhibitor of N8-acetylspermidine deacetylation in mice and HeLa cells without effects on histone deacetylation. Marchant, P., Dredar, S., Manneh, V., Alshabanah, O., Matthews, H., Fries, D., Blankenship, J. Arch. Biochem. Biophys. (1989) [Pubmed]
  16. Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue. Blankenship, J. Arch. Biochem. Biophys. (1978) [Pubmed]
  17. The formation of radiolabeled N1- and N8-acetylspermidine in various rat organs following [14C]spermidine administration. Prussak, C.E., Brendel, K. Int. J. Biochem. (1983) [Pubmed]
  18. Acetylation of polyamines in chicken brain and retina. Grillo, M.A., Dianzani, U., Pezzali, D.C. Int. J. Biochem. (1984) [Pubmed]
  19. Preparation of antibodies highly specific to N1,N8-diacetylspermidine, and development of an enzyme-linked immunosorbent assay (ELISA) system for its sensitive and specific detection. Hiramatsu, K., Miura, H., Sugimoto, K., Kamei, S., Iwasaki, K., Kawakita, M. J. Biochem. (1997) [Pubmed]
  20. Separation of several free polyamines and their acetylated derivatives by ion-pair reversed-phase high performance liquid chromatography. Aboul-Enein, H.Y., al-Duraibi, I.A. Biomed. Chromatogr. (1998) [Pubmed]
  21. Polyamines biosynthesis and oxidation in free-living amoebae. Ruggeri, P., Laganà, G., Bellocco, E., Fabiano, C., Leonaldi, R., Forino, D. Amino Acids (2004) [Pubmed]
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