Disease relevance of sebacic acid

• Allergic contact dermatitis from ethyl sebacate [1].
• Toxicity of disodium sebacate [2].
• Contact dermatitis due to diethyl sebacate [3].
• Thus, we examined the effect of a continuous intravenous infusion of the sodium salt of the 10-carbon atom alyphatic dicarboxylic acid, sebacate (Sb), on insulin-dependent glucose metabolism in four control subjects, four patients with insulin-dependent diabetes mellitus, and four obese subjects [4].
• Phenol biodegradation by a cold adapted Pseudomonas strain was therefore tested at 14 or 4 degrees C using 2-undecanone, diethyl sebacate or 2-decanone as organic phases in a two-phase partitioning bioreactor [5].

High impact information on sebacic acid

• Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate is a highly potent (IC50 values < 10 nM) inhibitor at the phenylalkylamine- and benzothiazepine-selective drug-binding domains of the alpha 1 subunit of L-type Ca2+ channels [6].
• (1)H NMR spectroscopic studies of bis[(2-dibenzo-24-crown-8)methyl] sebacate (C8C) with dibenzylammonium hexafluorophosphate (6) showed that the two binding sites of the ditopic host are equivalent and independent (no positive or negative cooperativity) [7].
• The methacrylic/acrylic membranes without plasticizer were shown to give an order of magnitude lower detection limit, when compared with PVC-dioctyl sebacate and o-nitrophenyl octyl ether plasticized methacrylic/acrylic polymers under the same conditions, highlighting the influence of plasticizer on the detection limit [8].
• The compositions of thick optode membranes, especially the ratios of poly(vinyl chloride) (PVC) to plasticizer [bis-(2-ethylhexyl) sebacate (DOS)], were carefully optimized to provide reproducible and rapid response [9].
• When disodium sebacate is administered i.v. for total parenteral nutrition, a substantial fraction of sebacic anions is likely to be bound in serum [10].

Chemical compound and disease context of sebacic acid

• Allergic contact dermatitis due to diethyl sebacate in a hand cream [11].
• Allergic contact dermatitis due to diisopropyl sebacate [12].
• Allergic contact dermatitis from diethyl sebacate in lanoconazole cream [13].

Biological context of sebacic acid

• EAD and AD were measured with boluses of 0.7-micrometer particles of di-2-ethylhexl sebacate, with Pen (i.e., volumetric bolus penetration/total lung capacity) between 0.1 and 0 [14].
• In 47 children, aged 11 +/- 2 yrs, with mild asthma (forced expiratory volume in one second (FEV1) 83 +/- 9% of forced vital capacity (FVC)) effective airway diameters were derived from the recovery of inhaled 1 micron sebacate droplets [15].
• Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate [16].
• On the contrary LD50 +/- s.e. of 5500 +/- 830 mg/kg b.w. and 6000 +/- 850 mg/kg b.w. were found respectively for rats and rabbits after i.p. sebacate administration [2].
• Kinetics and thermogenesis of medium-chain monocarboxylic and dicarboxylic acids in man: sebacate and medium-chain triglycerides [17].

Anatomical context of sebacic acid

• In the second group, expired 14CO2, urine tracer and feces tracer were counted after intravenous administration of 160 mg of sebacate [18].
• The sebacate half-life is longest in adipose tissue (135 min) and in liver (74 min), sites of likely transformation [18].

Associations of sebacic acid with other chemical compounds

• Polymerization of divinyl sebacate and glycerol using Candida antarctica lipase as catalyst in the presence of unsaturated higher fatty acids produced the polyesters having an unsaturated group in the side chain [19].
• Glucose uptake, plasma sebacate, insulin, glucagon, C-peptide, and ketone bodies were measured [4].

Analytical, diagnostic and therapeutic context of sebacic acid

• Sebacate in serum and urine was measured by high-performance liquid chromatography [16].
• These data showed a good tissue fixation of sebacate [20].

References