Disease relevance of trichloromethane

• The behavioral toxicity of trichloromethane (TCM), dichlorobromomethane (DCBM), dibromochloromethane (DBCM) and tribromomethane (TBM) was evaluated following oral administration in mice [1].

High impact information on trichloromethane

• The only identified product was trichloromethane (CF), but CF production was not stoichiometric [2].
• Toxicology of organic drinking water contaminants: trichloromethane, bromodichloromethane, dibromochloromethane and tribromomethane [3].
• A behavioral teratology study was also conducted with TCM [1].
• Both parents were treated with 31.1 mg/kg/day TCM, and treatment of the dam continued throughout gestation and lactation [1].
• Nonresonant laser-induced multiphoton dissociation/ionization studies have been conducted for trichloromethane (CHCl3) and trichlorofluoromethane (CFCl3) at 355 nm, using time-of-flight mass spectrometry (TOFMS) [4].

Biological context of trichloromethane

• DCE and TCM at the highest concentration (1,000 ppm) provoked a biphasic response with an initial increase in KCI-induced muscle tension followed by a decrease [5].
• The objective of this research is to investigate the relationship between chlorine decay and the formations of disinfection by-products (DBP), including trichloromethane (TCM) and chloroacetic acid (CAA) in the presence of four model compounds, i.e., resorcinol, phloroglucinol, p-hydroxybenzoic acid, and m-hydroxybenzoic acid [6].
• Formation of trichloromethane free radicals and the mixed function oxidase locus in the smooth endoplasmic reticulum of the hepatocyte and subsequent initiation of lipid peroxidation at this site are the first of a complex series of events that lead to the expression of CCl4 toxicity [7].

Anatomical context of trichloromethane

• Cardiotoxicity of chlorodibromomethane and trichloromethane in rats and isolated rat cardiac myocytes [8].
• Thus, the effects of ACHs such as dichloromethane (DCM), dichloroethane (DCE), and trichloromethane (TCM), on the basal and stimulant-induced contractile responses in piglet tracheal smooth muscle were investigated [5].

Associations of trichloromethane with other chemical compounds

• For TNF in DMSO, in aqueous acetone, in surfactant micelles, and in trichloromethane extracts of ionic associatiates with N(n-Bu)4+ and N(n-Hept)4+, the deeply colored 'quinon-phenolate' dianion, typical for all hydroxyxanthenes, is not registered at all [9].
• Solvates from 2-propanol (SII), trichloromethane (SIII) and tetrachloromethane (SIV) have been characterized [10].

Gene context of trichloromethane

• The Vv-PBHA complex was preconcentrated by solvent extraction into trichloromethane and injected on to a silica gel column for HPLC, with a mobile phase of methanol-trichloromethane (3 + 97) containing 9.4 x 10(-4) mol dm-3 PBHA [11].

Analytical, diagnostic and therapeutic context of trichloromethane

• ALMs were isolated by XAD-2 column chromatography and separated by silica gel chromatography and trichloromethane/MeOH gradient elution into an acidic and neutral group of peptides, named ALM F30 and ALM F50, respectively, according to their 100 Rf on TLC [12].

References