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Chemical Compound Review

Gadolinium-153     gadolinium

Synonyms: AC1L4OPM, 153Gd, 14276-65-4, Gadolinium, isotope of mass 153
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Disease relevance of gadolinium

  • Comparison of the distribution of flow determined by radiolabeled gadolinium-153 at onset of ischemia with that indicated by radiolabeled tin-113 microspheres given at the end of various periods of ischemia revealed no change in the position or steepness of the flow interface at any time during the first 2 hours of ischemia [1].
  • CONCLUSIONS: Glioblastoma multiforme cells may extend over the Gd area and more widely with increasing tumour size on Gd-MRI [2].

High impact information on gadolinium


Biological context of gadolinium


Anatomical context of gadolinium

  • Concentrations of MS-325 in blood, urine, feces, and organs were determined using gadolinium-153-labeled MS-325 and gamma counting or by using non-labeled MS-325 and inductively coupled plasma atomic emission spectrometry [10].
  • The uptake of Gd as a function of time in the perilymphatic space of the vestibular labyrinth was shown by ANOVA and PLSD post hoc tests to be significantly less (p < 0.05) than that of the scala tympani of the cochlea 10, 30, 60 and 90 min after i.v. injection [7].
  • Dual energy gadolinium-153 photonabsorptiometry was used to measure distal leg bone loss at a skeletal segment distant from the fracture to exclude callus formation [11].
  • The combination of Gd and furosemide is the key for achieving a uniform distribution of the contrast material inside the entire urinary tract [12].
  • This study describes the synthesis, characterization and in vitro evaluation of targetable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-gadolinium (Gd) chelates for enhanced magnetic resonance imaging (MRI) of macrophages [13].

Associations of gadolinium with other chemical compounds

  • Equimolar concentrations of Gd and Yb show a higher in vitro contrast and enhancement than iodine [14].
  • The purpose of this work was to evaluate the enhancement of different concentrations of gadolinium (Gd), ytterbium (Yb) and iodine in vitro and in vivo [14].
  • All lung blocks were perfused with a glucose-insulin-potassium solution, and distribution within the lung parenchyma and tracheobronchial tissue was measured using the flow reference technique and gadolinium-153-labeled microspheres [15].

Analytical, diagnostic and therapeutic context of gadolinium


  1. Temporal and spatial characteristics of evolving cell injury during regional myocardial ischemia in the dog: the "border zone" controversy. Yellon, D.M., Hearse, D.J., Crome, R., Wyse, R.K. J. Am. Coll. Cardiol. (1983) [Pubmed]
  2. Discrepancy between lesion distributions on methionine PET and MR images in patients with glioblastoma multiforme: insight from a PET and MR fusion image study. Miwa, K., Shinoda, J., Yano, H., Okumura, A., Iwama, T., Nakashima, T., Sakai, N. J. Neurol. Neurosurg. Psychiatr. (2004) [Pubmed]
  3. Regional myocardial capillary erythrocyte transit time in the normal resting heart. Allard, M.F., Kamimura, C.T., English, D.R., Henning, S.L., Wiggs, B.R. Circ. Res. (1993) [Pubmed]
  4. Attenuation-corrected thallium-201 single-photon emission tomography using a gadolinium-153 moving line source: clinical value and the impact of attenuation correction on the extent and severity of perfusion abnormalities. Gallowitsch, H.J., Sykora, J., Mikosch, P., Kresnik, E., Unterweger, O., Molnar, M., Grimm, G., Lind, P. European journal of nuclear medicine. (1998) [Pubmed]
  5. Dosimetry of transmission measurements in nuclear medicine: a study using anthropomorphic phantoms and thermoluminescent dosimeters. Almeida, P., Bendriem, B., de Dreuille, O., Peltier, A., Perrot, C., Brulon, V. European journal of nuclear medicine. (1998) [Pubmed]
  6. Effect of attenuation correction on myocardial thallium-201 distribution in patients with a low likelihood of coronary artery disease. Prvulovich, E.M., Lonn, A.H., Bomanji, J.B., Jarritt, P.H., Ell, P.J. European journal of nuclear medicine. (1997) [Pubmed]
  7. 3D MRI of the in vivo vestibulo-cochlea labyrinth during Gd-DTPA-BMA uptake. Counter, S.A., Zou, J., Bjelke, B., Klason, T. Neuroreport (2003) [Pubmed]
  8. Dual photon absorptiometry using a gadolinium-153 source applied to measure equine bone mineral content. Moure, A., Reichmann, P., Gamba, H.R. Physics in medicine and biology. (2003) [Pubmed]
  9. The biological effects of Auger electrons compared to alpha-particles and Li ions. Laster, B.H., Shani, G., Kahl, S.B., Warkentien, L. Acta oncologica (Stockholm, Sweden) (1996) [Pubmed]
  10. Preclinical evaluation of the pharmacokinetics, biodistribution, and elimination of MS-325, a blood pool agent for magnetic resonance imaging. Parmelee, D.J., Walovitch, R.C., Ouellet, H.S., Lauffer, R.B. Investigative radiology. (1997) [Pubmed]
  11. Quantification by dual photonabsorptiometry of local bone loss after fracture. Ulivieri, F.M., Bossi, E., Azzoni, R., Ronzani, C., Trevisan, C., Montesano, A., Ortolani, S. Clin. Orthop. Relat. Res. (1990) [Pubmed]
  12. Diuretic contrast-enhanced magnetic resonance urography versus intravenous urography for depiction of nondilated urinary tracts. El-Diasty, T., Mansour, O., Farouk, A. Abdominal imaging. (2003) [Pubmed]
  13. Macrophage Targeted N-(2-Hydroxypropyl)methacrylamide Conjugates for Magnetic Resonance Imaging. Zarabi, B., Nan, A., Zhuo, J., Gullapalli, R., Ghandehari, H. Mol. Pharm. (2006) [Pubmed]
  14. Computed tomography with iodine-free contrast media. Zwicker, C., Hering, M., Langer, R. European radiology. (1997) [Pubmed]
  15. Effect of prostaglandin E2 on the tracheobronchial distribution of lung preservation perfusate. Santillan-Doherty, P., Sotres-Vega, A., Jasso-Victoria, R., Olmos-Zuñiga, R., Arreola-Ramirez, J.L., Cedillo-Ley, I. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (1998) [Pubmed]
  16. Influence of arm positioning on tomographic thallium-201 myocardial perfusion imaging and the effect of attenuation correction. Prvulovich, E.M., Jarritt, P.H., Lonn, A.H., Vorontsova, E., Bomanji, J.B., Ell, P.J. European journal of nuclear medicine. (2000) [Pubmed]
  17. Hepatobiliary magnetic resonance contrast agents assessed by gadolinium-153 scintigraphy. Engelstad, B.L., White, D.L., Huberty, J.P., Wynne, C.S., Ramos, E.C., McNamara, M.T., Goldberg, H.I. Investigative radiology. (1987) [Pubmed]
  18. Diagnostic notes--lumbar BMC reproducibility as evaluated by means of dual photon absorptiometry. Isaia, G., Mussetta, M., Salamano, G., Carlevatto, V., Molinatti, G.M. Maturitas. (1988) [Pubmed]
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