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Chemical Compound Review

Duxon     N-(2-hydroxypropyl)-2-methyl- prop-2-enamide

Synonyms: AG-E-57145, CTK4E6787, AKOS006344692, AC1L206H, A815380, ...
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Disease relevance of Duxon


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Chemical compound and disease context of Duxon


Biological context of Duxon


Anatomical context of Duxon


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Gene context of Duxon


Analytical, diagnostic and therapeutic context of Duxon


  1. Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. Nishiyama, N., Nori, A., Malugin, A., Kasuya, Y., Kopecková, P., Kopecek, J. Cancer Res. (2003) [Pubmed]
  2. Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin. O'Hare, K.B., Hume, I.C., Scarlett, L., Chytrý, V., Kopecková, P., Kopecek, J., Duncan, R. Hepatology (1989) [Pubmed]
  3. Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer. Duncan, R., Vicent, M.J., Greco, F., Nicholson, R.I. Endocr. Relat. Cancer (2005) [Pubmed]
  4. Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Seymour, L.W., Miyamoto, Y., Maeda, H., Brereton, M., Strohalm, J., Ulbrich, K., Duncan, R. Eur. J. Cancer (1995) [Pubmed]
  5. Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. Jensen, K.D., Kopecková, P., Kopecek, J. Bioconjug. Chem. (2002) [Pubmed]
  6. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Vasey, P.A., Kaye, S.B., Morrison, R., Twelves, C., Wilson, P., Duncan, R., Thomson, A.H., Murray, L.S., Hilditch, T.E., Murray, T., Burtles, S., Fraier, D., Frigerio, E., Cassidy, J. Clin. Cancer Res. (1999) [Pubmed]
  7. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Omelyanenko, V., Gentry, C., Kopecková, P., Kopecek, J. Int. J. Cancer (1998) [Pubmed]
  8. Synthesis and characterization of HE-24.8: a polymeric contrast agent for magnetic resonance angiography. Kiessling, F., Heilmann, M., Lammers, T., Ulbrich, K., Subr, V., Peschke, P., Waengler, B., Mier, W., Schrenk, H.H., Bock, M., Schad, L., Semmler, W. Bioconjug. Chem. (2006) [Pubmed]
  9. Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice. Shiah, J.G., Dvorák, M., Kopecková, P., Sun, Y., Peterson, C.M., Kopecek, J. Eur. J. Cancer (2001) [Pubmed]
  10. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. Omelyanenko, V., Kopecková, P., Gentry, C., Kopecek, J. Journal of controlled release : official journal of the Controlled Release Society. (1998) [Pubmed]
  11. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro. Omelyanenko, V., Kopecková, P., Gentry, C., Shiah, J.G., Kopecek, J. Journal of drug targeting. (1996) [Pubmed]
  12. Effect of the chemical structure of N-(2-hydroxypropyl)methacrylamide copolymers on their ability to induce antibody formation in inbred strains of mice. Rihová, B., Kopecek, J., Ulbrich, K., Pospisil, M., Mancal, P. Biomaterials (1984) [Pubmed]
  13. The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Wang, D., Miller, S.C., Sima, M., Parker, D., Buswell, H., Goodrich, K.C., Kopecková, P., Kopecek, J. Pharm. Res. (2004) [Pubmed]
  14. DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers. Oupický, D., Konák, C., Ulbrich, K., Wolfert, M.A., Seymour, L.W. Journal of controlled release : official journal of the Controlled Release Society. (2000) [Pubmed]
  15. Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies. Pimm, M.V., Perkins, A.C., Duncan, R., Ulbrich, K. Journal of drug targeting. (1993) [Pubmed]
  16. Biorecognition of HPMA copolymer-adriamycin conjugates by lymphocytes mediated by synthetic receptor binding epitopes. Omelyanenko, V., Kopecková, P., Prakash, R.K., Ebert, C.D., Kopecek, J. Pharm. Res. (1999) [Pubmed]
  17. Immunosuppressive effects of a synthetic polymer poly N-(2-hydroxypropyl)methacrylamide (Duxon). Paluska, E., Cinátl, J., Korcáková, L., Stĕrba, O., Kopecek, J., Hrubá, A., Nezvalová, J., Stanĕk, R. Folia Biol. (Praha) (1980) [Pubmed]
  18. Pinocytic uptake and intracellular degradation of N-(2-hydroxypropyl)methacrylamide copolymers. A potential drug delivery system. Duncan, R., Rejmanova, P., Kopecek, J., Lloyd, J.B. Biochim. Biophys. Acta (1981) [Pubmed]
  19. Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia. Duncan, R., Kopecková, P., Strohalm, J., Hume, I.C., Lloyd, J.B., Kopecek, J. Br. J. Cancer (1988) [Pubmed]
  20. Gamma scintigraphy of a 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate containing galactosamine following intravenous administration to nude mice bearing hepatic human colon carcinoma. Pimm, M.V., Perkins, A.C., Strohalm, J., Ulbrich, K., Duncan, R. Journal of drug targeting. (1996) [Pubmed]
  21. Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. Wang, D., Miller, S.C., Liu, X.M., Anderson, B., Wang, X.S., Goldring, S.R. Arthritis Res. Ther. (2007) [Pubmed]
  22. Macrophage Targeted N-(2-Hydroxypropyl)methacrylamide Conjugates for Magnetic Resonance Imaging. Zarabi, B., Nan, A., Zhuo, J., Gullapalli, R., Ghandehari, H. Mol. Pharm. (2006) [Pubmed]
  23. A possibility to overcome P-glycoprotein (PGP)-mediated multidrug resistance by antibody-targeted drugs conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier. St'astný, M., Strohalm, J., Plocová, D., Ulbrich, K., Ríhová, B. Eur. J. Cancer (1999) [Pubmed]
  24. Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance. Tijerina, M., Fowers, K.D., Kopecková, P., Kopecek, J. Biomaterials (2000) [Pubmed]
  25. Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates. Flanagan, P.A., Kopecková, P., Kopecek, J., Duncan, R. Biochim. Biophys. Acta (1989) [Pubmed]
  26. Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates. Lu, Z.R., Gao, S.Q., Kopecková, P., Kopecek, J. Bioconjug. Chem. (2000) [Pubmed]
  27. The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine. Wróblewski, S., Ríhová, B., Rossmann, P., Hudcovicz, T., Reháková, Z., Kopecková, P., Kopecek, J. Journal of drug targeting. (2001) [Pubmed]
  28. N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation. Searle, F., Gac-Breton, S., Keane, R., Dimitrijevic, S., Brocchini, S., Sausville, E.A., Duncan, R. Bioconjug. Chem. (2001) [Pubmed]
  29. Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates. Kasuya, Y., Lu, Z.R., Kopecková, P., Minko, T., Tabibi, S.E., Kopecek, J. Journal of controlled release : official journal of the Controlled Release Society. (2001) [Pubmed]
  30. Gamma scintigraphy of the biodistribution of 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in mice with transplanted melanoma and mammary carcinoma. Pimm, M.V., Perkins, A.C., Strohalm, J., Ulbrich, K., Duncan, R. Journal of drug targeting. (1996) [Pubmed]
  31. Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells. Tijerina, M., Kopecková, P., Kopecek, J. Pharm. Res. (2003) [Pubmed]
  32. Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. Shiah, J.G., Sun, Y., Kopecková, P., Peterson, C.M., Straight, R.C., Kopecek, J. Journal of controlled release : official journal of the Controlled Release Society. (2001) [Pubmed]
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