Disease relevance of ytterbium

• The cells of Streptomyces sp. YB-1 adsorbed 4-6 mg ytterbium (Yb) per g dry weight [1].

High impact information on ytterbium

• The anomalous difference Fourier map revealed that two ytterbium ions (Yb(3+)) could bind the catalytic site of EF.CaM in the presence of cAMP and PP(i), suggesting the presence of two magnesium ions at the catalytic site of EF [2].
• Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography [3].
• The new ytterbium(II) thiocyanate complex [Yb(NCS)2(thf)2] (1), synthesised by redox transmetallation between [Hg(SCN)2] and ytterbium metal in THF at room temperature, gave monomeric, eight coordinate [Yb-(NCS)2(dme)3] (2, dme = 1,2-dimethoxyethane) on crystallisation from DME, and is a powerful, synthetically useful reductant [4].
• RESULTS: At 120 kV, in vitro CT attenuation of gadolinium and ytterbium exceeded that of iodine by 41% and 45%, respectively, when measured at equal mass concentrations (in milligrams per milliliter of saline) [5].
• Praseodymium and ytterbium chlorides were used as nuclear magnetic resonance shift reagents to resolve the inner and outer choline methyl resonances of single-walled dimyristoylphosphatidylcholine bilayer vesicles [6].

Chemical compound and disease context of ytterbium

• Distribution of ytterbium (Yb) in cells of Streptomyces sp. YB-1 which can accumulate Yb, and reusability of cells and cell membrane as bioadsorbent for Yb [1].

Biological context of ytterbium

• A novel ytterbium binding site is also found at the dimer two-fold axis, near residues Asp-270 and Glu-272, and this site may be related to the reported inhibition by lanthanide metals (Achyuthan, K. E., Mary, A., and Greenberg, C. S. (1989) Biochem. J. 257, 331-338) [3].
• Key steps involve oxidative decarboxylation of N-acyl-alpha-amino acid intermediates, followed by ytterbium triflate mediated solvolysis [7].
• The molecular structure of the ate complex 4 exhibits a heavily distorted trigonal-bipyramidal coordination polyhedron about the ytterbium atom, with one of the mu-chlorine atoms and the oxygen atom of the tetrahydrofuran ligand representing the axial positions of the trigonal-bipyramidal arrangement [8].
• Of interest is that the NIR luminescence of the erbium ion in Er(1/2)Yb(1/2)(HFA)(3)(TPPO)(2) is significantly enhanced because of the coexistence of the ytterbium ion through the energy-transfer between the ytterbium and erbium ions [9].
• The LD50 of intravenous ytterbium-DTPA was 10 mM/kg (1.73 g ytterbium/kg) in rats [10].

Anatomical context of ytterbium

• Complexation of ytterbium to human transferrin and its uptake by K562 cells [11].
• 2. Continuous intrarumen infusions (8 d) of chromium and ytterbium were made in order to measure the flow of digesta through the rumen, duodenum and ileum with 15NH4Cl included in the infusate for the final 3 d [12].
• Turnover rates of solids were determined by appearance of ytterbium in feces [13].
• 2. Samples of duodenal digesta representative of a 24 h period were obtained using chromium-EDTA and ytterbium acetate for flow estimation and 35S as a marker of microbial N entering the small intestine [14].
• Results indicated that the immobilized cells of P. aeruginosa enable removal of lanthanum, europium and ytterbium ions from aqueous effluents with significant and similar maximum adsorption capacities [15].

Associations of ytterbium with other chemical compounds

• In whole cell patch clamp recordings, it was discovered that the trivalent lanthanides (Ln(3+)s) lanthanum and ytterbium interact with two binding sites to modulate K(+) flow through these channels [16].
• The crystal structure of carp parvalbumin 4.25 containing a 1:1 molar ratio of ytterbium chloride to protein has been refined at 1.5 A resolution by restrained least-squares methods to a crystallographic R value of 0.199 [17].
• Pump-induced nonlinear refractive-index change in erbium- and ytterbium-doped fibers: theory and experiment [18].
• Aromatic aldimines (1) were dimerized in the presence of 0.5 mol of ytterbium metal (Yb) and 1-naphthaldehyde (1-NpCHO) to give the corresponding vicinal diimines (2) in good to high yields [19].
• The syntheses and molecular structures of a number of 2,6-di(o-anisol)phenyl ([double bond]Danip-) -based bis(amide) and bis(alkoxide) compounds of ytterbium, yttrium, and samarium are reported [20].

Gene context of ytterbium

• Titration of Ca2+-saturated parvalbumin with ytterbium (YB3+) demonstrate that Yb3+ sequentially replaces the two bound calcium ions of the protein [21].
• Three closely related rhombohedral crystal structures of human annexin V have been analysed and compared: a low-calcium, a high-calcium and an ytterbium-soaked crystal [22].
• In enhanced CT scans and pulmonary angiography in dogs, ytterbium was visibly denser than iodine, and CT Hounsfield units showed greater enhancement of the aorta and inferior vena cava with ytterbium [10].
• 5. In the neighbouring unit cells in the (001) plane there is, however, a strong tendency towards an alternating distribution of ytterbium in positions shifted by Delta z = 1/2 [23].
• 171Yb cross polarisation/magic angle spinning (CP/MAS) is introduced as a new analytical tool for the investigation and structural characterisation of divalent ytterbium complexes [24].

Analytical, diagnostic and therapeutic context of ytterbium

• The solution structures of the ytterbium heterobimetallic complexes Na(3)[Yb((S)-BINOL)(3)] (1), K(3)[Yb((S)-BINOL)(3)] (2), and Li(3)[Yb((S)-BINOL)(3)] (3), belonging to a family of well-known enantioselective catalysts, are studied by means of NMR and circular dichroism (CD) in the UV and near-IR regions [25].
• A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy [26].
• Ruminal turnover rates of liquid were measured with chromium-ethylenediaminetetraacetate and solid turnover rates with ytterbium-marked fecal fiber, both dosed through the ruminal cannula [27].
• Radioactive microspheres, labeled withe ytterbium (169Yb), strontium (85Sr) and cerium (141Ce) were used in an investigation of the cardiovascular response to superficial thiopental anesthesia [28].
• The potential of ytterbium 169 in brachytherapy: a brief physical and radiobiological assessment [29].

References