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Chemical Compound Review

YTTERBIUM     ytterbium

Synonyms: yterbio, ACMC-1BKDU, AG-D-84536, CHEBI:33381, KST-1A1428, ...
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Disease relevance of ytterbium


High impact information on ytterbium


Chemical compound and disease context of ytterbium


Biological context of ytterbium

  • A novel ytterbium binding site is also found at the dimer two-fold axis, near residues Asp-270 and Glu-272, and this site may be related to the reported inhibition by lanthanide metals (Achyuthan, K. E., Mary, A., and Greenberg, C. S. (1989) Biochem. J. 257, 331-338) [3].
  • Key steps involve oxidative decarboxylation of N-acyl-alpha-amino acid intermediates, followed by ytterbium triflate mediated solvolysis [7].
  • The molecular structure of the ate complex 4 exhibits a heavily distorted trigonal-bipyramidal coordination polyhedron about the ytterbium atom, with one of the mu-chlorine atoms and the oxygen atom of the tetrahydrofuran ligand representing the axial positions of the trigonal-bipyramidal arrangement [8].
  • Of interest is that the NIR luminescence of the erbium ion in Er(1/2)Yb(1/2)(HFA)(3)(TPPO)(2) is significantly enhanced because of the coexistence of the ytterbium ion through the energy-transfer between the ytterbium and erbium ions [9].
  • The LD50 of intravenous ytterbium-DTPA was 10 mM/kg (1.73 g ytterbium/kg) in rats [10].

Anatomical context of ytterbium

  • Complexation of ytterbium to human transferrin and its uptake by K562 cells [11].
  • 2. Continuous intrarumen infusions (8 d) of chromium and ytterbium were made in order to measure the flow of digesta through the rumen, duodenum and ileum with 15NH4Cl included in the infusate for the final 3 d [12].
  • Turnover rates of solids were determined by appearance of ytterbium in feces [13].
  • 2. Samples of duodenal digesta representative of a 24 h period were obtained using chromium-EDTA and ytterbium acetate for flow estimation and 35S as a marker of microbial N entering the small intestine [14].
  • Results indicated that the immobilized cells of P. aeruginosa enable removal of lanthanum, europium and ytterbium ions from aqueous effluents with significant and similar maximum adsorption capacities [15].

Associations of ytterbium with other chemical compounds


Gene context of ytterbium

  • Titration of Ca2+-saturated parvalbumin with ytterbium (YB3+) demonstrate that Yb3+ sequentially replaces the two bound calcium ions of the protein [21].
  • Three closely related rhombohedral crystal structures of human annexin V have been analysed and compared: a low-calcium, a high-calcium and an ytterbium-soaked crystal [22].
  • In enhanced CT scans and pulmonary angiography in dogs, ytterbium was visibly denser than iodine, and CT Hounsfield units showed greater enhancement of the aorta and inferior vena cava with ytterbium [10].
  • 5. In the neighbouring unit cells in the (001) plane there is, however, a strong tendency towards an alternating distribution of ytterbium in positions shifted by Delta z = 1/2 [23].
  • 171Yb cross polarisation/magic angle spinning (CP/MAS) is introduced as a new analytical tool for the investigation and structural characterisation of divalent ytterbium complexes [24].

Analytical, diagnostic and therapeutic context of ytterbium

  • The solution structures of the ytterbium heterobimetallic complexes Na(3)[Yb((S)-BINOL)(3)] (1), K(3)[Yb((S)-BINOL)(3)] (2), and Li(3)[Yb((S)-BINOL)(3)] (3), belonging to a family of well-known enantioselective catalysts, are studied by means of NMR and circular dichroism (CD) in the UV and near-IR regions [25].
  • A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy [26].
  • Ruminal turnover rates of liquid were measured with chromium-ethylenediaminetetraacetate and solid turnover rates with ytterbium-marked fecal fiber, both dosed through the ruminal cannula [27].
  • Radioactive microspheres, labeled withe ytterbium (169Yb), strontium (85Sr) and cerium (141Ce) were used in an investigation of the cardiovascular response to superficial thiopental anesthesia [28].
  • The potential of ytterbium 169 in brachytherapy: a brief physical and radiobiological assessment [29].


  1. Distribution of ytterbium (Yb) in cells of Streptomyces sp. YB-1 which can accumulate Yb, and reusability of cells and cell membrane as bioadsorbent for Yb. Pertiwiningrum, A., Ino, Y., Suzuki, T., Iwama, T., Kawai, K. J. Biosci. Bioeng. (2004) [Pubmed]
  2. Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate. Guo, Q., Shen, Y., Zhukovskaya, N.L., Florián, J., Tang, W.J. J. Biol. Chem. (2004) [Pubmed]
  3. Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography. Fox, B.A., Yee, V.C., Pedersen, L.C., Le Trong, I., Bishop, P.D., Stenkamp, R.E., Teller, D.C. J. Biol. Chem. (1999) [Pubmed]
  4. Diverse heteroleptic ytterbium(III) thiocyanate complexes by oxidation from bis(thiocyanato)ytterbium(II). Deacon, G.B., Forsyth, C.M., Wilkinson, D.L. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  5. Gd-EOB-DTPA and Yb-EOB-DTPA: two prototypic contrast media for CT detection of liver lesions in dogs. Schmitz, S.A., Wagner, S., Schuhmann-Giampieri, G., Krause, W., Bollow, M., Wolf, K.J. Radiology. (1997) [Pubmed]
  6. Lack of transbilayer coupling in phase transitions of phosphatidylcholine vesicles. Sillerud, L.O., Barnett, R.E. Biochemistry (1982) [Pubmed]
  7. Studies toward the synthesis of (-)-zampanolide: preparation of N-acyl hemiaminal model systems. Troast, D.M., Porco, J.A. Org. Lett. (2002) [Pubmed]
  8. Synthesis and structural characterization of 2,6-dimesitylphenyl complexes of scandium, ytterbium, and yttrium. Rabe, G.W., Bérubé, C.D., Yap, G.P., Lam, K.C., Concolino, T.E., Rheingold, A.L. Inorganic chemistry. (2002) [Pubmed]
  9. Novel stoichiometrically erbium-ytterbium cocrystalline complex exhibiting enhanced near-infrared luminescence. Zhong, Q., Wang, H., Qian, G., Wang, Z., Zhang, J., Qiu, J., Wang, M. Inorganic chemistry. (2006) [Pubmed]
  10. Ytterbium-DTPA. A potential intravascular contrast agent. Unger, E., Gutierrez, F. Investigative radiology. (1986) [Pubmed]
  11. Complexation of ytterbium to human transferrin and its uptake by K562 cells. Du, X.L., Zhang, T.L., Yuan, L., Zhao, Y.Y., Li, R.C., Wang, K., Yan, S.C., Zhang, L., Sun, H., Qian, Z.M. Eur. J. Biochem. (2002) [Pubmed]
  12. The effect of haemonchosis and blood loss into the abomasum on digestion in sheep. Rowe, J.B., Nolan, J.V., de Chaneet, G., Teleni, E., Holmes, P.H. Br. J. Nutr. (1988) [Pubmed]
  13. Effects of supplemental potassium and sodium chloride salts on ruminal turnover rates, acid-base and mineral status of lactating dairy cows during heat stress. Schneider, P.L., Beede, D.K., Wilcox, C.J. J. Anim. Sci. (1988) [Pubmed]
  14. The importance of the form of nitrogen on microbial protein synthesis in the rumen of cattle receiving grass silage and continuous intrarumen infusions of sucrose. Rooke, J.A., Armstrong, D.G. Br. J. Nutr. (1989) [Pubmed]
  15. Fixed-bed study for lanthanide (La, Eu, Yb) ions removal from aqueous solutions by immobilized Pseudomonas aeruginosa: experimental data and modelization. Texier, A.C., Andrès, Y., Faur-Brasquet, C., Le Cloirec, P. Chemosphere (2002) [Pubmed]
  16. Dual actions of lanthanides on ACTH-inhibited leak K(+) channels. Enyeart, J.J., Xu, L., Enyeart, J.A. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  17. Refined crystal structure of ytterbium-substituted carp parvalbumin 4.25 at 1.5 A, and its comparison with the native and cadmium-substituted structures. Kumar, V.D., Lee, L., Edwards, B.F. FEBS Lett. (1991) [Pubmed]
  18. Pump-induced nonlinear refractive-index change in erbium- and ytterbium-doped fibers: theory and experiment. Garcia, H., Johnson, A.M., Oguama, F.A., Trivedi, S. Optics letters. (2005) [Pubmed]
  19. A novel reductive dimerization/oxidative dehydrogenation of aldimines mediated by lanthanoid metals. Jin, W., Makioka, Y., Kitamura, T., Fujiwara, Y. J. Org. Chem. (2001) [Pubmed]
  20. Donor-functionalized lanthanide terphenyl complexes: Synthesis and structural characterization of 2,6-di(o-anisol)phenyl compounds of ytterbium, yttrium, and samarium. Rabe, G.W., Zhang-Presse, M., Riederer, F.A., Yap, G.P. Inorganic chemistry. (2003) [Pubmed]
  21. Proton nuclear magnetic resonance determination of the sequential ytterbium replacement of calcium in carp parvalbumin. Lee, L., Sykes, B.D. Biochemistry (1981) [Pubmed]
  22. The interaction of metal ions with annexin V: a crystallographic study. Lewit-Bentley, A., Bentley, G.A., Favier, B., L'Hermite, G., Renouard, M. FEBS Lett. (1994) [Pubmed]
  23. Diffuse X-ray scattering and reverse Monte Carlo simulation of the short-range order in ytterbium iodine phthalocyanine [YbPc(2)]I(2). Krawczyk, J., Pietraszko, A., Łukaszewicz, K. Acta Crystallogr., B (2002) [Pubmed]
  24. 171Yb cross polarisation/magic-angle spinning of divalent ytterbium complexes. Rabe, G.W., Sebald, A. Solid state nuclear magnetic resonance. (1996) [Pubmed]
  25. Solution versus solid-state structure of ytterbium heterobimetallic catalysts. Di Bari, L., Lelli, M., Pintacuda, G., Pescitelli, G., Marchetti, F., Salvadori, P. J. Am. Chem. Soc. (2003) [Pubmed]
  26. A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy. Aime, S., Botta, M., Fasano, M., Terreno, E., Kinchesh, P., Calabi, L., Paleari, L. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1996) [Pubmed]
  27. Nycterohemeral patterns of acid-base status, mineral concentrations and digestive function of lactating cows in natural or chamber heat stress environments. Schneider, P.L., Beede, D.K., Wilcox, C.J. J. Anim. Sci. (1988) [Pubmed]
  28. Hemodynamics during superficial thiopental anesthesia in the dog. Ahlgren, I., Aronsen, K.F., Björkman, I., Wetterlin, S. Acta anaesthesiologica Scandinavica. (1978) [Pubmed]
  29. The potential of ytterbium 169 in brachytherapy: a brief physical and radiobiological assessment. Loft, S.M., Coles, I.P., Dale, R.G. The British journal of radiology. (1992) [Pubmed]
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