Disease relevance of Decadron

• Cataracts induced by intermittent Decadron used as an antiemetic [1].
• One hundred five untreated adult patients with acute lymphocytic leukemia (ALL) were entered on the vincristine, Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), and Decadron (dexamethasone; Merck Sharp and Dohme, West Point, PA) (VAD) regimen [2].
• CONCLUSION: The presence of pretreatment edema and lesion size are not predictors of post-SRS complication rates or the ability to taper Decadron [3].
• Decadron in the treatment of cerebral abscess. An experimental study [4].
• Our findings confirm other reports that paclitaxel chemotherapy hypersensitivity reactions can be decreased with a single-dose intravenous decadron premedication regimen and that patients who do have paclitaxel HSRs may be safely retreated with paclitaxel [5].

High impact information on Decadron

• METHODS AND MATERIALS: Forty-seven evaluable patients with 63 lesions were treated on a 6-MV linear accelerator radiosurgery system at Memorial Sloan Kettering Cancer Center. All patients received a 10-mg intravenous bolus of dexamethasone sodium phosphate (Decadron) prior to SRS [3].
• Inhibition of pituitary bioactive prolactin secretion in the male rat by the glucocorticoid agonist decadron phosphate [6].
• Premedication consisted of single-dose intravenous decadron, benadryl, and cimetidine administered immediately prior to chemotherapy [5].
• Administration of Decadron, chemotherapy and 3,000 rad cranial radiation resulted in dramatic improvement of dysphasia and right hand paresis [7].
• The effect of glucocorticoid on the maturation of premature lung membranes was studied in 121 premature infants by administering variable dosages of Decadron to the 114 mothers prior to delivery [8].

Chemical compound and disease context of Decadron

• A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea [1].
• For brain metastases, immediate treatment with dexamethasone (Decadron, Dexone, Hexadrol) is indicated [9].

Anatomical context of Decadron

• Dexamethasone (Decadron) caused minimal damage, while hydrocortisone (Solu-Cortef) and triamcinolone hexacetonide (Aristospan) caused widespread axonal and myelin degeneration [10].
• Morphological and histochemical examinations of the changes induced in the adrenal cortex by the administration of Dexamethasone (Decadron phosphate) to rats for 14 consecutive days were made at intervals during a 28-day post-treatment period, in order to follow the histo-functional recovery of this gland from the changes induced [11].

Associations of Decadron with other chemical compounds

• From the results of our experiment it was concluded that Dimer X of low concentration should be used with premedication of Valium and Decadron [12].

Gene context of Decadron

• Three comatose patients who were being kept on Decadron without benefit recovered from coma [13].
• A multicentre double-blind comparative trial was performed in 138 patients with rheumatoid arthritis (RA) after biweekly intravenous or intramuscular injections of liposteroid (containing 2.5 mg of dexamethasone), which had been developed as a drug for targeting therapy of RA, and Decadron (containing 3.3 mg of dexamethasone) as a reference drug [14].
• Conservative management with Decadron for 3 weeks resulted in a prompt clinical improvement, and a CT scan 1 month later showed resolution of the lesion, effectively ruling out a glioma [15].
• Dexamethasone sodium phosphate (Decadron) versus saline placebo injections in strabismus surgery [16].

Analytical, diagnostic and therapeutic context of Decadron

• Two of these patients received additional oral decadron followed by the standard premedication and were successfully retreated with multiple courses of paclitaxel therapy without reaction [5].
• Response was assessed every 8 weeks using CT/MRI scan and clinical criteria including decadron requirement [17].
• In spite of emergent radiotherapy and large dose decadron treatment, this patient still had severe sequela of paraplegia and incontinence [18].

References