Disease relevance of disodium fluoro-dioxido-oxo-phosphorane

• The preponderance of evidence indicates that sodium monofluorophosphate exerts a highly beneficial effect on dental caries incidence and enamel solubility [1].
• Although the ability of dental plaque to hydrolyze sodium monofluorophosphate (MFP) has been known for some time, its effect on the F- concentration at the plaque-enamel interface is undefined [2].
• Efficacy of a dentifrice containing 5% potassium nitrate and 1500 PPM sodium monofluorophosphate in a precipitated calcium carbonate base on dentinal hypersensitivity [3].
• The effect of sodium fluoride and sodium monofluorophosphate at concentrations of 1, 5, 10, 50, 100 and 1000 mg/l in phosphate buffer (pH 6.5) as well as in UHT milk were studied on cultures and suspensions of Streptococcus mutans, Lactobacillus acidophilus and Candida albicans [4].

High impact information on disodium fluoro-dioxido-oxo-phosphorane

• Effect of sodium monofluorophosphate and calcium on bone density and fracture rate in osteoporosis [5].
• Male and female Drosophila melanogaster with special sex chromosome or special autosome constitutions were fed with the mutagenic chemicals Trenimon (2,3,5-trisethyleneimino-1,4-benzoquinone) and PDMT (1-phenyl-3, 3-dimethyltriazene) and with the toxic substance Na2PO3F (sodium monofluorophosphate) [6].
• These effects may be dose dependent and, in this study, we examine the pharmacokinetics of sodium monofluorophosphate (MFP) in osteoporotic patients and relate this to changes in BMD [7].
• This study evaluated the dose-response relationship between four increasing levels of fluoride from 1000 to 2500 ppm F as sodium monofluorophosphate (MFP) and three-year dental caries increments, as measured by DMFS, DMFT, and DFS-A on 4424 schoolchildren [8].
• Acceleration of remineralization in vitro by sodium monofluorophosphate and sodium fluoride [9].

Biological context of disodium fluoro-dioxido-oxo-phosphorane

• The aim of the present work was to study the usefulness of disodium monofluorophosphate (MFP) as a milk-fluoridating agent by measuring the bioavailability of F from MFP in milk relative to that of F from NaF in water [10].
• Acid hydrolysis of aqueous sodium monofluorophosphate solutions [11].
• Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoride when it was administered intragastrically as NaF, disodium monofluorophosphate (Na2PO3F, MFP) or NaF and MFP [12].
• The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared [13].
• Intestinal absorption of disodium monofluorophosphate in the rat as affected by concurrent administration of calcium [14].

Anatomical context of disodium fluoro-dioxido-oxo-phosphorane

• Fluoride uptake in vivo by artificial caries lesions in root surface dentin from sodium monofluorophosphate dentifrices [15].
• The effect of calcium on disodium monofluorophosphate absorption from the gastrointestinal tract of rats [16].
• The absorption of fluoride from disodium monofluorophosphate with or without added calcium has been studied in ligated stomachs and duodena of rats, in vivo [16].

Associations of disodium fluoro-dioxido-oxo-phosphorane with other chemical compounds

• Fluoride bioavailability from disodium monofluorophosphate fluoridated milk in children and rats [10].
• A 3-year clinical trial of calcium carbonate dentifrice containing calcium glycerophosphate and sodium monofluorophosphate [17].
• Interaction between chlorhexidine digluconate and sodium monofluorophosphate in vitro [18].
• An ion chromatographic method for simultaneous quantitative determination of fluorine and sodium monofluorophosphate in oral hygiene products is described [19].
• A double-blind clinical trial of an anticalculus toothpaste containing pyrophosphate and sodium monofluorophosphate [20].

Gene context of disodium fluoro-dioxido-oxo-phosphorane

• This paper reports a reassessment of the bioavailability of fluoride from monofluorophosphate (MFP, CAS 10163-15-2) [21].

Analytical, diagnostic and therapeutic context of disodium fluoro-dioxido-oxo-phosphorane

• Aqueous solutions of NaF and sodium monofluorophosphate (MFP) were given to fasting young adults in an intra-individual cross-over study [22].
• Six lesions were placed into the buccal surfaces of lower partial dentures of seven subjects, covered with a stainless steel mesh to provide a plaque cover, and brushed with either a sodium monofluorophosphate or placebo dentifrice for four weeks, by means of a double-blind random cross-over design [23].
• A 3-yr daily supervised toothbrushing study with a double blind design was conducted to evaluate the anticaries effectiveness of a 1.14% sodium monofluorophosphate (MFP) dentifrice (1500 ppm F) compared to a 0.76% MFP dentifrice (1000 ppm F) [24].
• In the control group an abrasive paste was used containing 5% sodium monofluorophosphate (Jodka Fluor Polerpasta) [25].
• Effect of disodium monofluorophosphate, calcium and vitamin D supplementation on bone mineral density in patients chronically treated with glucocorticosteroids: a prospective, randomized, double-blind study [26].

References