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Chemical Compound Review

CIPC     propan-2-yl N-(3-chlorophenyl)carbamate

Synonyms: ChlorIPC, Taterpex, Elbanil, Metoxon, Mirvale, ...
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Disease relevance of chlorpropham

  • Developmental toxicity of chlorpropham in mice [1].
  • At the end of CIPC administration, dose-dependent and significant methemoglobinemia, anemia, splenomegaly and pathological lesions indicating hemolytic anemia were observed in all the treated groups [2].
  • The results indicated that hematological changes induced by sub-chronic administration of CIPC were reversible but hemosiderin deposition and fibrosis in spleen were not reversible in the recovery period examined, suggesting the significance of splenic lesion in CIPC-toxicity [2].

High impact information on chlorpropham


Biological context of chlorpropham

  • In contrast, the hydrolysis of chlorpropham was inhibited by montmorillonite, probably because of its strong adsorption on montmorillonite [8].
  • There were no adverse effects of chlorpropham on either litter size or litter weight and sex ratio at birth [9].
  • After incubation for 12 hours at the restrictive temperature, 20% of the CIPC 6 amoebae displayed condensed chromosomes, compared to 2% at the permissive temperature, as determined by Giemsa staining [10].
  • CIPC treatment resulted in unequal cell divisions at atypical times, and skeletal spicule formation in these embryos was abnormal [11].
  • Chlorpropham was administered to pregnant mice by gavage at a level of 0 (control), 750, 1500, and 3000 mg/kg bw on Day 8.3 of gestation, and the females were killed on Day 18 of gestation [1].

Anatomical context of chlorpropham


Associations of chlorpropham with other chemical compounds


Gene context of chlorpropham


Analytical, diagnostic and therapeutic context of chlorpropham


  1. Developmental toxicity of chlorpropham in mice. Tanaka, T., Fujitani, T., Takahashi, O., Oishi, S., Yoneyama, M. Reprod. Toxicol. (1997) [Pubmed]
  2. Chlorpropham-induced splenotoxicity and its recovery in rats. Fujitani, T., Tada, Y., Yoneyama, M. Food Chem. Toxicol. (2004) [Pubmed]
  3. Bcl-1 RFLP at the human hepatic lipase gene locus (CIPC). Li, S.R., Chan, L., Thorn, J., Galton, D.J., Stocks, J. Nucleic Acids Res. (1991) [Pubmed]
  4. Immunofluorescence microscopy of microtubules in intact cell lineages of the moss, Physcomitrella patens. I. Normal and CIPC-treated tip cells. Doonan, J.H., Cove, D.J., Lloyd, C.W. J. Cell. Sci. (1985) [Pubmed]
  5. Anti-herbicide single-chain antibody expression confers herbicide tolerance in transgenic plants. Eto, J., Suzuki, Y., Ohkawa, H., Yamaguchi, I. FEBS Lett. (2003) [Pubmed]
  6. cps1+, a Schizosaccharomyces pombe gene homolog of Saccharomyces cerevisiae FKS genes whose mutation confers hypersensitivity to cyclosporin A and papulacandin B. Ishiguro, J., Saitou, A., Durán, A., Ribas, J.C. J. Bacteriol. (1997) [Pubmed]
  7. Optimization of microwave-assisted extraction and supercritical fluid extraction of carbamate pesticides in soil by experimental design methodology. Sun, L., Lee, H.K. Journal of chromatography. A. (2003) [Pubmed]
  8. Influence of clay minerals on the hydrolysis of carbamate pesticides. Wei, J., Furrer, G., Kaufmann, S., Schulin, R. Environ. Sci. Technol. (2001) [Pubmed]
  9. Reproductive and neurobehavioral effects of chlorpropham administered to mice in the diet. Tanaka, T. Toxicology and industrial health. (1997) [Pubmed]
  10. Biochemical and genetic approaches to microtubule function in Dictyostelium discoideum. White, E., Katz, E.R. Methods Cell Biol. (1987) [Pubmed]
  11. Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos. Holy, J. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  12. Cadmium-induced alterations of chlorpropham metabolism in isolated rat hepatocytes. Alary, J., Carrera, G., Lamboeuf, Y., Escrieut, C. Toxicology (1989) [Pubmed]
  13. Hemotoxicity of chlorpropham (CIPC) in F344 rats. Fujitani, T., Tada, Y., Noguchi, A.T., Yoneyama, M. Toxicology (1997) [Pubmed]
  14. Metabolism of chlorpropham by adult rat hepatocytes co-cultured with a liver epithelial cell line. Carrera, G., Alary, J., Lamboeuf, Y., Anglade, F., Escrieut, C., Pinchon, C. Food additives and contaminants. (1990) [Pubmed]
  15. Effects of modulation of sulphation and glucuronidation on chlorpropham metabolism and cytotoxicity in isolated rat hepatocytes. Carrera, G., Lamboeuf, Y., Pipy, B., Alary, J., Melgar, M.J. Veterinary and human toxicology. (1995) [Pubmed]
  16. Cardiac index measurements during rapid preload changes: a comparison of pulmonary artery thermodilution with arterial pulse contour analysis. Felbinger, T.W., Reuter, D.A., Eltzschig, H.K., Bayerlein, J., Goetz, A.E. Journal of clinical anesthesia. (2005) [Pubmed]
  17. The role of microfilaments and microtubules in apical growth and dimorphism of Candida albicans. Yokoyama, K., Kaji, H., Nishimura, K., Miyaji, M. J. Gen. Microbiol. (1990) [Pubmed]
  18. Determination of chlorprophame residues in potatoes by GC-NPD or GC-MS. Pigeon, O., de Vos, P., Potvin, J., Thiry, K., Villette, D., Vandenberghe, J.P., Huyghebaert, B., Noel, S. Communications in agricultural and applied biological sciences. (2005) [Pubmed]
  19. Residue analysis of isopropyl N-(3-Chlorophenyl)carbamate in fruits and vegetables using high-performance liquid chromatography. Wilson, A.M., Bushway, A.A., Bushway, R.J. J. Agric. Food Chem. (1981) [Pubmed]
  20. The heterogeneity of sprout inhibitor application with chlorpropham. Noël, S., Huyghebaert, B., Pigeon, O., Weickmans, B., Mostade, O. Communications in agricultural and applied biological sciences. (2003) [Pubmed]
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