Disease relevance of CLAVULANATE POTASSIUM

• Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections [1].
• A single-blinded, randomized, parallel clinical trial in 10 centers in the United States compared the efficacy and safety of loracarbef with that of amoxicillin/clavulanate potassium in the treatment of acute bacterial maxillary sinusitis [2].
• In this study, both fleroxacin and amoxicillin/clavulanate potassium were effective and well tolerated in the treatment of skin and soft tissue infections [3].
• In a one-year follow-up, 11 of the 19 patients treated with penicillin and two of the 18 treated with amoxycillin/clavulanate potassium had recurrent streptococcal tonsillitis (P less than 0.005) [4].
• Treatment of symptomatic chronic adenotonsillar hypertrophy with amoxicillin/clavulanate potassium: short- and long-term results [5].

Psychiatry related information on CLAVULANATE POTASSIUM

• DUE (drug usage evaluation) of ticarcillin and clavulanate potassium: determining appropriate and cost-effective therapeutic options [6].

High impact information on CLAVULANATE POTASSIUM

• Ticarcillin disodium plus clavulanate potassium (in a ratio of 30:1) was used to treat 30 children (mean age equal to 4.9 years) with acute infections of the urinary tract, skeletal system, respiratory tract, gastrointestinal tract, skin and subcutaneous tissue, and blood [7].
• Ticarcillin disodium plus clavulanate potassium appears to be safe and effective therapy for a wide range of acute infections in children, including those caused by at least some pathogens that produce beta-lactamase [7].
• The antibacterial effects produced by ticarcillin disodium plus clavulanate potassium, a combination of the broad-spectrum penicillin ticarcillin, and the beta-lactamase inhibitor clavulanic acid as the potassium salt, have been measured in vitro and in experimental infection studies [8].
• A prospective randomized clinical study comparing the efficacy of penicillin-V potassium with amoxycillin plus clavulanate potassium (Augmentin) in the treatment of acute episodes of recurrent streptococcal tonsillitis was conducted [4].
• Amoxicillin and clavulanate potassium proved to be an effective therapy symptomatically and resulted in disappearance of the extremely long organisms in vaginal smears [9].

Chemical compound and disease context of CLAVULANATE POTASSIUM

• Treatment of patients with acute recurrent tonsillitis due to group A beta-haemolytic streptococci: a prospective randomized study comparing penicillin and amoxycillin/clavulanate potassium [4].
• Comparative trial of cefprozil vs. amoxicillin clavulanate potassium in the treatment of children with acute otitis media with effusion [10].
• Eighty-four randomly chosen women with postcesarean endomyometritis received 3 g ticarcillin disodium plus 100 mg clavulanate potassium intravenously every six hours [11].
• CASE SUMMARY: A 75-year-old man receiving long-term warfarin therapy developed a lower respiratory tract infection with paroxysmal coughing that was treated with oral amoxicillin 250 mg/clavulanate potassium 125 mg TID for 7 days [12].
• Loracarbef (LY 163892), a beta-lactam antibiotic (carbacephem), was compared with amoxicillin/clavulanate potassium in a 10-day, single-blind, randomized parallel trial in the treatment of acute bacterial maxillary sinusitis [13].

Biological context of CLAVULANATE POTASSIUM

• Bioequivalence of clavulanate potassium and amoxicillin (1:7) dispersible tablets in healthy volunteers [14].

Anatomical context of CLAVULANATE POTASSIUM

• When persistent middle ear effusion was analyzed by pneumatic otoscopy, 64 of 103 affected ears (62.1%) treated with cefprozil and 80 of 105 affected ears (76.1%) treated with amoxicillin clavulanate potassium were abnormal (P = 0.04) [10].

Analytical, diagnostic and therapeutic context of CLAVULANATE POTASSIUM

• OBJECTIVE: To report a case of warfarin-amoxicillin/clavulanate potassium (AM/CL) interaction resulting in an elevated international normalized ratio (INR) and hematuria [15].
• Ticarcillin disodium/clavulanate potassium and other beta-lactamase inhibitor/penicillin combinations have been recognized recently as broad-spectrum drugs that have a major role in chemotherapy for serious surgical sepsis [16].

References