Disease relevance of Olea

• BACKGROUND: Olive tree (Olea europaea) pollen is an important cause of pollinosis in countries of the Mediterranean area and California. OBJECTIVE: The aim of this study was to identify and purify a new allergen of olive tree pollen [1].
• An allergen from Olea europaea pollen (Ole e 7) is associated with plant-derived food anaphylaxis [2].
• BACKGROUND: Olea europaea pollen is an important cause of seasonal allergic rhinitis and bronchial asthma in southern Spain. For patients allergic to grass pol- len the critical concentration of airborn pollen is 50 grains/m3, but in the case of Olea pollinosis no data is available [3].
• Fifteen (88.2%) of the 17 patients who had IgE reactivity in their sera to olive tree pollen antigen demonstrated allergic reactions to an extract of olive tree pollen [4].

High impact information on Olea

• NMR solution structure of Ole e 6, a major allergen from olive tree pollen [5].
• BACKGROUND: The major antigen of olive tree pollen, Ole e 1, produces an IgE response restricted by DQ2 [6].
• Recently, Ole e 1, the major allergen from olive tree pollen, has been isolated and its amino acid sequence has been elucidated [7].
• IgE-binding and histamine-release capabilities of the main carbohydrate component isolated from the major allergen of olive tree pollen, Ole e 1 [7].
• Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen [8].

Biological context of Olea

• Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts [9].
• This low RNA editing frequency might correlate with both the GC content observed in the cox3 gene and the phylogenetic position of Olea [10].

Anatomical context of Olea

• Differential effects of oleuropein, a biophenol from Olea europaea, on anionic and zwiterionic phospholipid model membranes [11].
• Changes that take place in the hemicellulosic and cellulosic polysaccharide fractions of the cell wall of olives (Olea europaea pomiformis, Manzanilla variety) during "Spanish style" processing have been studied [12].
• A peroxidative activity was found in solubilized thylakoid membranes of olives (Olea europaea) cv. hojiblanca that catalyses degradation of chloroplast pigments in the presence of H2O2 and 2,4-dichlorophenol (DCP) [13].

Associations of Olea with chemical compounds

• Horseradish peroxidase, bromelain, and ascorbate oxidase are recognized by the IgE of sera from patients who are hypersensitive to olive tree pollen [14].
• Alternative pathways for phosphatidylcholine synthesis in olive (Olea europaea L.) callus cultures [15].
• One of the most effective in terms of free radical scavenging is 3,4-dihydroxyphenyl ethanol or hydroxytyrosol (HT), a simple phenol found predominantly in Olea europea, or the olive plant [16].
• Total RNA from the olive tree pollen was isolated, and a specific cDNA was amplified by the polymerase chain reaction using a degenerate oligonucleotide primer designed according to the NH2-terminal sequence of the protein [17].
• Oleuropein (Ole) is the major phenolic constituent of the olive leaf (Olea europaea) and it is also present in olive oil and fruit [11].

Gene context of Olea

• We report the characterisation of two cytochrome b5 genes and their spatial and temporal patterns of expression during development in olive, Olea europaea [18].
• Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent [19].
• Most of our monosensitized patients needed a high Olea pollen concentration in the atmosphere (around 400 grains/m3) to suffer at least from mild allergic rhinitis symptoms [3].
• A cDNA encoding Ole e 3, a major allergen from olive-tree pollen, has been cloned and sequenced [20].
• Cloning and Expression of the Olea europaea allergen Ole e 5, the pollen Cu/Zn superoxide dismutase [21].

Analytical, diagnostic and therapeutic context of Olea

• Monoclonal antibodies against Olea europaea major allergen: allergenic activity of affinity-purified allergen and depleted extract and development of a radioimmunoassay for the quantitation of the allergen [22].
• The Ole e 6 allergen from olive tree pollen has been isolated by combining gel permeation and reverse-phase chromatographies [17].
• Purification of allergens by high-performance liquid chromatography. IV. Purification of the allergen of olive pollen (Olea europea) [23].
• Molecular cloning and expression of active Ole e 3, a major allergen from olive-tree pollen and member of a novel family of Ca2+-binding proteins (polcalcins) involved in allergy [20].
• Two different cDNA sequences, designated OepFAD2-1 and OepFAD2-2, encoding two microsomal oleate desaturases (FAD2) have been isolated from olive (Olea europaea cv. Picual) using a PCR approach [24].

References