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Disease relevance of Pueraria


High impact information on Pueraria


Biological context of Pueraria


Anatomical context of Pueraria


Associations of Pueraria with chemical compounds


Gene context of Pueraria

  • A continuing study of the ingredients of Puerariae Radix, the roots of Pueraria lobata (WILLD.) OHWI, which is one of the most important crude drugs, has resulted in the first isolation of four new oleanene-type triterpene glycosides, named kudzusaponins SA1, SA2, SA3 and C1 (1-4) [23].
  • Biochemical studies of a new class of alcohol dehydrogenase inhibitors from Radix puerariae [24].
  • Pharmacological studies on Puerariae flos III: protective effects of kakkalide on ethanol-induced lethality and acute hepatic injury in mice [25].
  • A glycoside flavonoid in Kudzu (Pueraria lobata): identification, quantification, and determination of antioxidant activity [26].
  • The aim of this study was to identify whether Puerariae radix extract induces osteogenic activity in human osteoblast-like SaOS-2 cells [18].

Analytical, diagnostic and therapeutic context of Pueraria


  1. Cross-reaction of chalcone synthase and stilbene synthase overexpressed in Escherichia coli. Yamaguchi, T., Kurosaki, F., Suh, D.Y., Sankawa, U., Nishioka, M., Akiyama, T., Shibuya, M., Ebizuka, Y. FEBS Lett. (1999) [Pubmed]
  2. Puerarin acts through brain serotonergic mechanisms to induce thermal effects. Chueh, F.S., Chang, C.P., Chio, C.C., Lin, M.T. J. Pharmacol. Sci. (2004) [Pubmed]
  3. Pharmacological studies on Puerariae Flos. IV: Effects of Pueraria thomsonii dried flower extracts on blood ethanol and acetaldehyde levels in humans. Yamazaki, T., Hosono, T., Matsushita, Y., Kawashima, K., Someya, M., Nakajima, Y., Narui, K., Hibi, Y., Ishizaki, M., Kinjo, J., Nohara, T. International journal of clinical pharmacology research. (2002) [Pubmed]
  4. Potentiation of the bioavailability of daidzin by an extract of Radix puerariae. Keung, W.M., Lazo, O., Kunze, L., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Evolution of the isoprene biosynthetic pathway in kudzu. Sharkey, T.D., Yeh, S., Wiberley, A.E., Falbel, T.G., Gong, D., Fernandez, D.E. Plant Physiol. (2005) [Pubmed]
  6. Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Lin, R.C., Li, T.K. Am. J. Clin. Nutr. (1998) [Pubmed]
  7. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. Shen, P., Liu, M.H., Ng, T.Y., Chan, Y.H., Yong, E.L. J. Nutr. (2006) [Pubmed]
  8. Comparative analysis of Pseudomonas syringae pv. actinidiae and pv. phaseolicola based on phaseolotoxin-resistant ornithine carbamoyltransferase gene (argK) and 16S-23S rRNA intergenic spacer sequences. Sawada, H., Takeuchi, T., Matsuda, I. Appl. Environ. Microbiol. (1997) [Pubmed]
  9. Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis. Hashim, M.F., Hakamatsuka, T., Ebizuka, Y., Sankawa, U. FEBS Lett. (1990) [Pubmed]
  10. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Chiang, H.M., Fang, S.H., Wen, K.C., Hsiu, S.L., Tsai, S.Y., Hou, Y.C., Chi, Y.C., Chao, P.D. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  11. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. Boué, S.M., Wiese, T.E., Nehls, S., Burow, M.E., Elliott, S., Carter-Wientjes, C.H., Shih, B.Y., McLachlan, J.A., Cleveland, T.E. J. Agric. Food Chem. (2003) [Pubmed]
  12. High-performance liquid chromatography-tandem mass spectrometry for identification of isoflavones and description of the biotransformation of kudzu root. Zhang, Y., Xu, Q., Zhang, X., Chen, J., Liang, X., Kettrup, A. Analytical and bioanalytical chemistry. (2005) [Pubmed]
  13. Effects of crude drugs on lipolysis in differentiated 3T3-L1 adipocytes. Hong, S.J., Fong, J.C., Hwang, J.H. The Kaohsiung journal of medical sciences. (2002) [Pubmed]
  14. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Hsu, H.H., Chang, C.K., Su, H.C., Liu, I.M., Cheng, J.T. Planta Med. (2002) [Pubmed]
  15. Isolation, sequence and bacterial expression of a cDNA for chalcone synthase from the cultured cells of Pueraria lobata. Nakajima, O., Akiyama, T., Hakamatsuka, T., Shibuya, M., Noguchi, H., Ebizuka, Y., Sankawa, U. Chem. Pharm. Bull. (1991) [Pubmed]
  16. Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. Bo, J., Ming, B.Y., Gang, L.Z., Lei, C., Jia, A.L. Neurosci. Res. (2005) [Pubmed]
  17. Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. Jun, M., Hong, J., Jeong, W.S., Ho, C.T. Molecular nutrition & food research. (2005) [Pubmed]
  18. Puerariae radix promotes differentiation and mineralization in human osteoblast-like SaOS-2 cells. Huh, J.E., Yang, H.R., Park, D.S., Choi, D.Y., Baek, Y.H., Cho, E.M., Cho, Y.J., Kang-Il, K., Kim, D.Y., Lee, J.D. Journal of ethnopharmacology. (2006) [Pubmed]
  19. Separation and purification of isoflavones from Pueraria lobata by high-speed counter-current chromatography. Cao, X., Tian, Y., Zhang, T., Li, X., Ito, Y. Journal of chromatography. A. (1999) [Pubmed]
  20. Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. Lin, R.C., Guthrie, S., Xie, C.Y., Mai, K., Lee, D.Y., Lumeng, L., Li, T.K. Alcohol. Clin. Exp. Res. (1996) [Pubmed]
  21. Analysis of Puerariae radix and its medicinal preparations by capillary electrophoresis. Wang, C.Y., Huang, H.Y., Kuo, K.L., Hsieh, Y.Z. Journal of chromatography. A. (1998) [Pubmed]
  22. An overexpression of chalcone reductase of Pueraria montana var. lobata alters biosynthesis of anthocyanin and 5'-deoxyflavonoids in transgenic tobacco. Joung, J.Y., Kasthuri, G.M., Park, J.Y., Kang, W.J., Kim, H.S., Yoon, B.S., Joung, H., Jeon, J.H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  23. Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination. Arao, T., Kinjo, J., Nohara, T., Isobe, R. Chem. Pharm. Bull. (1995) [Pubmed]
  24. Biochemical studies of a new class of alcohol dehydrogenase inhibitors from Radix puerariae. Keung, W.M. Alcohol. Clin. Exp. Res. (1993) [Pubmed]
  25. Pharmacological studies on Puerariae flos III: protective effects of kakkalide on ethanol-induced lethality and acute hepatic injury in mice. Yamazaki, T., Nakajima, Y., Niho, Y., Hosono, T., Kurashige, T., Kinjo, J., Nohara, T. J. Pharm. Pharmacol. (1997) [Pubmed]
  26. A glycoside flavonoid in Kudzu (Pueraria lobata): identification, quantification, and determination of antioxidant activity. Lau, C.S., Carrier, D.J., Beitle, R.R., Howard, L.R., Lay, J.O., Liyanage, R., Clausen, E.C. Appl. Biochem. Biotechnol. (2005) [Pubmed]
  27. Narrow-bore HPLC analysis of isoflavonoid aglycones and their O- and C-glycosides from Pueraria lobata. Rong, H., De Keukeleire, D., De Cooman, L., Baeyens, W.R., Van der Weken, G. Biomed. Chromatogr. (1998) [Pubmed]
  28. Plant derivatives in the treatment of alcohol dependency. Rezvani, A.H., Overstreet, D.H., Perfumi, M., Massi, M. Pharmacol. Biochem. Behav. (2003) [Pubmed]
  29. HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone. Yan, B., Xing, D., Ding, Y., Tao, J., Du, L.J. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  30. Antitumor activity of spinasterol isolated from Pueraria roots. Jeon, G.C., Park, M.S., Yoon, D.Y., Shin, C.H., Sin, H.S., Um, S.J. Exp. Mol. Med. (2005) [Pubmed]
  31. Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor. Kintzios, S., Makri, O., Pistola, E., Matakiadis, T., Shi, H.P., Economou, A. Biotechnol. Lett. (2004) [Pubmed]
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