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Chemical Compound Review

Shogaol     (E)-1-(4-hydroxy-3-methoxy- phenyl)dec-4-en...

Synonyms: CHEMBL25948, SureCN971812, CCRIS 2038, CHEBI:131487, NSC-752389, ...
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Disease relevance of Shogaol


High impact information on Shogaol


Biological context of Shogaol

  • The foremost protective effect of shogaol in SCI would therefore be manifested in the suppression of the acute secondary apoptotic cell death [2].
  • It was found that gingerol exhibited novel reversible kinetics, in which it undergoes dehydration-hydration transformations with shogaol, the major degradation product [4].
  • It was observed that ginger extract, gingerol and shogaol were mutagenic on metabolic activation in strains TA 100 and TA 1535, but zingerone was non-mutagenic in all the four strains with or without S9 mix [5].
  • (6)-Shogaol-induced pressor responses in blood pressure of rats were studied [6].

Anatomical context of Shogaol

  • Our data show that the therapeutic outcome of shogaol probably results from its comprehensive effects of blocking apoptotic cell death, resulting in the protection of white matter, oligodendrocytes and neurons, and inhibiting astrogliosis [2].
  • In addition, 6-shogaol ameliorated BaCl(2) -induced hyperperistalsis of the small intestine in vivo [7].
  • CONCLUSION: From these results, it is concluded that 6-shogaol reduced the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats [8].
  • The effect of 6-shogaol compared to the controls was associated with significantly lower concentration of soluble vascular cell adhesion molecule-1 (VCAM-1) in the blood and infiltration of leukocytes, including lymphocytes and monocytes/macrophages, into the synovial cavity of the knee [8].

Associations of Shogaol with other chemical compounds


Analytical, diagnostic and therapeutic context of Shogaol


  1. The effect of extracts from ginger rhizome on inflammatory mediator production. Lantz, R.C., Chen, G.J., Sarihan, M., Sólyom, A.M., Jolad, S.D., Timmermann, B.N. Phytomedicine (2007) [Pubmed]
  2. 6-Shogaol, a natural product, reduces cell death and restores motor function in rat spinal cord injury. Kyung, K.S., Gon, J.H., Geun, K.Y., Sup, J.J., Suk, W.J., Ho, K.J. Eur. J. Neurosci. (2006) [Pubmed]
  3. Variation in concentration and labeling of ginger root dietary supplements. Schwertner, H.A., Rios, D.C., Pascoe, J.E. Obstetrics and gynecology. (2006) [Pubmed]
  4. The stability of gingerol and shogaol in aqueous solutions. Bhattarai, S., Tran, V.H., Duke, C.C. Journal of pharmaceutical sciences. (2001) [Pubmed]
  5. Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay. Nagabhushan, M., Amonkar, A.J., Bhide, S.V. Cancer Lett. (1987) [Pubmed]
  6. Pharmacological studies on ginger. III. Effect of the spinal destruction on (6)-shogaol-induced pressor response in rats. Suekawa, M., Aburada, M., Hosoya, E. J. Pharmacobio-dyn. (1986) [Pubmed]
  7. Component of Zingiber officinale that improves the enhancement of small intestinal transport. Hashimoto, K., Satoh, K., Murata, P., Makino, B., Sakakibara, I., Kase, Y., Ishige, A., Higuchi, M., Sasaki, H. Planta Med. (2002) [Pubmed]
  8. 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant. Levy, A.S., Simon, O., Shelly, J., Gardener, M. BMC Pharmacol. (2006) [Pubmed]
  9. Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. Suekawa, M., Ishige, A., Yuasa, K., Sudo, K., Aburada, M., Hosoya, E. J. Pharmacobio-dyn. (1984) [Pubmed]
  10. Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric vascular beds of rats. Suekawa, M., Aburada, M., Hosoya, E. J. Pharmacobio-dyn. (1986) [Pubmed]
  11. Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action. Onogi, T., Minami, M., Kuraishi, Y., Satoh, M. Neuropharmacology (1992) [Pubmed]
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