Disease relevance of Libido

• While hypogonadism, manifested by decreased libido and potency, was apparent at the time of estrogen administration, galactorrhea appeared two months after estrogen was discontinued [1].
• Chronic treatment with agonist analogs of GnRH results in reversible oligospermia in man, but leads to impotence and decreased libido due to a concomitant fall in serum testosterone (T) concentrations [2].
• Androgen deficiency in men is associated with severe osteopenia, alterations in body composition including an increase in fat mass, and decreased libido [3].
• Two sexual side effects associated with trazodone have been reported: priapism in men and increased libido in women [4].
• The absence of decreased libido or erectile dysfunction indicates that alpha1 adrenergic antagonism and not low serum testosterone due to hyperprolactinemia is the etiology for this side-effect [5].

Psychiatry related information on Libido

• Symptoms of androgen insufficiency in women may include a diminished sense of well-being, low mood, fatigue, and hypoactive sexual desire disorder with decreased libido, or decreased sexual receptivity and pleasure that causes a great deal of personal distress [6].
• As other side effects of propranolol include fatigue, diminished energy, decreased libido, anorexia and poor concentration, it is suggested that propranolol is a cause of organic mood disorder, depressed type [7].

High impact information on Libido

• Finally, diethylstilbestrol-exposed men had no impairment of sexual function, as indicated, for example, by the frequency of intercourse or reported episodes of decreased libido [8].
• Decreased libido and impotence were more common in patients given primidone [9].
• In the hypogonadal man whose only complaint is decreased libido, testosterone may be of benefit [10].
• Increased libido with trazodone [11].
• Decreased libido occurred more frequently in diazepam-treated patients, whereas increased libido was more frequent in clorazepate-treated patients [12].

Chemical compound and disease context of Libido

• Medroxyprogesterone therapy resulted in decreased libido, few side effects, and no recurrence of sex offenses, but there was no change in the patient's sexual orientation [13].
• Venlafaxine-induced increased libido and spontaneous erections [14].
• Most patients entered the study with decreased libido on fluoxetine [15].
• Citalopram-induced decreased libido [16].
• The decreased somnolence and increased libido and potency which accompanied therapy with levodopa suggest damage to dopaminergic and noradrenergic pathways [17].

Biological context of Libido

• However, preliminary data in postmenopausal women suggest that physiological androgen replacement therapy, which involves substantially lower doses than those used in men, may result in increased bone mineral density, increased libido, and improved quality of life [18].
• Menopause also results in a decline in androgen levels with resulting symptoms of decreased libido and sexual dysfunction [19].
• In the elderly >age 65 - DHEAS levels increase in both men and women with DHEA 50 mg/d but only in women were the higher DHEAS levels accompanied by a surge in testosterone levels and in women >age 70 increased libido and enhanced sexual satisfaction as well as a 26% diminution in bone resorption, and a 10% decrease in skin pigmentation [20].

Gene context of Libido

• Ten patients (33 per cent) with rheumatoid arthritis and four (13 per cent) with ankylosing spondylitis admitted to periods of impotence while 15 (50 per cent) of the former and 12 (39 per cent) of the latter had periods of decreased libido [21].
• Patients with epilepsy may have disturbances in sexual function such as anovulatory cycles in women and decreased libido and potency in men [22].
• AIMS AND METHODS: To describe patients with decreased libido during use of a HMG-CoA-reductase-inhibitor, and to discuss causality and pharmacological hypotheses for this association by analysis of the adverse drug reactions (ADR) database of the Netherlands Pharmacovigilance Centre Lareb [23].
• Nine of ten men aged 60 to 70 years with serum prolactin levels above 40 ng/ml reported decreased libido [24].
• Thirty-nine cases of decreased libido in glaucoma patients on carbonic anhydrase inhibitors are reported [25].

Analytical, diagnostic and therapeutic context of Libido

• Results from clinical studies show that hormone replacement therapy with estrogen plus androgens provides greater improvement in psychologic (eg, lack of concentration, depression, and fatigue) and sexual (eg, decreased libido and inability to have an orgasm) symptoms than does estrogen alone in naturally and surgically menopausal women [26].

References