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Chemical Compound Review

Kiton Brilliant Orange G     sodium(5E)-6-oxo-5- (phenylhydrazinylidene...

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Disease relevance of Kiton Brilliant Orange G

  • Peroral toxicity of Orange RN in pigs. Early haemotological changes [1].
  • Immunohistochemical findings, acid fuschin orange G staining and electromicroscope found no evidence of hepatitis B virus infection contributing to the pathogenesis of this lesion [2].
  • Destained smears (six defined as normal, six as inflammatory with squamous metaplasia, six as CIN I, six as CIN II, and five as CIN III) were submitted to the Ag-NOR method after staining with Orange G and EA36 [3].

Psychiatry related information on Kiton Brilliant Orange G

  • More than 80% of 10 mg/L Orange G decomposition in 60-minute reaction time was observed in this study and fast decomposition of Orange G only occurred in the presence of both TiO2 and suitable light energy [4].

High impact information on Kiton Brilliant Orange G

  • Interaction of Orange G (OG) with bovine plasma albumin (BPA) has been investigated using NMR, UV-visible absorption, CD, and fluorescence techniques [5].
  • Osteoclasts, osteoid, and mineralized bone were measured in a single section, reacted for acid phosphatase activity, and then stained with orange G and light green stain [6].
  • The orange G component of Mallory's trichrome stain had a high affinity for clavanins, and for the cytoplasmic granules of S. clava's hemocytes [7].
  • The putative STH cells are characterized by the presence of large dense secretory granules (250-300 nm) that are stained with orange-G by the trichrome method [8].
  • In vivo cytogenetic studies on mice exposed to Orange G, a food colourant [9].

Biological context of Kiton Brilliant Orange G

  • 25 mg/kg of Orange G was found to be the minimum effective dose for the induction of both SCEs and chromosome aberrations [9].
  • Oxidation of Crocein Orange G by lignin peroxidase isoenzymes. Kinetics and effect of H2O2 [10].
  • Deamination prevented eosin and orange G counterstains but did not impair nuclear stains with any of the mordant dye lakes [11].
  • Decolorization of Orange G and RBBR was studied also in liquid culture, where both dyes caused an enhancement of ligninolytic enzyme and overall hydrogen peroxide production and a decrease of biomass production [12].
  • Similarly induction of Heinz bodies, reduction of RBC and a rise in reticulocytes were demonstrated at our institute in pigs following a few weeks administration of Orange RN (P. Olsen et al., Toxicology, 1973, 101, 249) [1].

Anatomical context of Kiton Brilliant Orange G

  • Orange G and the century-old trichrome stain may provide simple screening tools for identifying cells that contain large amounts of antimicrobial peptides in mixed hemocyte populations [7].
  • Earlier experiments with Orange RN in rats have shown several changes in the blood i.g. induction of Heinz bodies, methaemoglobinaemia and reduction of RBC (J.F. Gaunt et al., Fd. Cosmet. Toxicol., 1971, 9, 619) [1].
  • Dyes with small size and molecular weight (i.e Orange G), penetrate all tissue structures rapidly, but are only tightly retained in densely textured tissues (i.e erythrocytes) [13].
  • The histological structures were stained with HE, and elastin, collagen and smooth muscles were stained with Weigert, Aniline blue and orange G, respectively [14].

Associations of Kiton Brilliant Orange G with other chemical compounds

  • The effect of enhanced laccase (Lac) activity (obtained after copper addition to cultivation media) on decolorization of azo dye Orange G in two basidiospore-derived monokaryotic isolates of Pleurotus ostreatus was determined [15].
  • Batch anaerobic reduction experiments were performed using two azo dyes, orange G and orange II, to determine reaction kinetics and to identify reduction products [16].
  • Both the adsorption capacities of crocein orange G (AO12) and acid green 25 (AG25), as the model compounds, decreased with increasing pH, and the decreasing effect was more significant for AO12 [17].
  • The technic uses equal strength solutions of orange G, acid fuchsin and methyl (or aniline) blue, in ascending order of molecular size, at pH 2.5 (range: 2.3 to 2.7) [18].

Gene context of Kiton Brilliant Orange G

  • Swiss albino male mice were exposed to Orange G through intraperitoneal injections [9].
  • The modification consisted of following two changes: use of Gill's Haematoxylin instead of RAH and omission of Orange G from cytostain [19].
  • The concentrations of beta MG and beta TP were determined based on the peak area relative to that of an internal standard, Orange G, which was added at a constant amount as the front marker [20].

Analytical, diagnostic and therapeutic context of Kiton Brilliant Orange G

  • Sensitive indirect photometric detection of inorganic and small organic anions by capillary electrophoresis using Orange G as a probe ion [21].
  • TSH cells identified by means of immunofluorescence were stained with the periodic acid-Schiff component of the performic acid-Alcian blue periodic acid-Schiff's Orange G stain [22].
  • In the present study, fine needle aspiration smears from 100 cases of breast lump were stained by modified ultrafast Papanicolaou stain which consisted of the following changes from ultrafast Papanicolaou stain: (i) Use of Gill 's haematoxylin instead of Richard Allan haematoxylin, (ii) omission of orange G from cytostain [23].


  1. Peroral toxicity of Orange RN in pigs. Early haemotological changes. Hansen, E., Olsen, P. Arch. Toxicol. Suppl. (1978) [Pubmed]
  2. Churg-Strauss syndrome with perforating ulcers of the colon. Kim, Y.B., Choi, S.W., Park, I.S., Han, J.Y., Hur, Y.S., Chu, Y.C. J. Korean Med. Sci. (2000) [Pubmed]
  3. Silver staining method for nucleolar organizer regions in cervical smears. Calore, E.E., Shirata, N.K., Shih, L.W., Cavaliere, M.J., de Siqueira, M. Diagn. Cytopathol. (1997) [Pubmed]
  4. Photocatalytic degradation of azo dye in TiO2 suspended solution. Hung, C.H., Chiang, P.C., Yuan, C., Chou, C.Y. Water Sci. Technol. (2001) [Pubmed]
  5. Interaction of 7-hydroxy-8-(phenylazo)1,3-naphthalenedisulfonate with bovine plasma albumin. Spectroscopic studies. Patel, A.B., Srivastava, S., Phadke, R.S. J. Biol. Chem. (1999) [Pubmed]
  6. Measurement of osteoclasts and bone resorption by automated image analysis. Dunstan, C.R., Lauren, P.D., Somers, N.M., Evans, R.A. J. Bone Miner. Res. (1993) [Pubmed]
  7. Immunolocalization of clavanins in Styela clava hemocytes. Menzel, L.P., Lee, I.H., Sjostrand, B., Lehrer, R.I. Dev. Comp. Immunol. (2002) [Pubmed]
  8. Light- and electron-microscopic studies on the secretory cytology of the adenohypophysis of the Japanese quail, Coturnix coturnix japonica. Mikami, S., Kurosu, T., Farner, D.S. Cell Tissue Res. (1975) [Pubmed]
  9. In vivo cytogenetic studies on mice exposed to Orange G, a food colourant. Giri, A.K., Mukherjee, A., Talukder, G., Sharma, A. Toxicol. Lett. (1988) [Pubmed]
  10. Oxidation of Crocein Orange G by lignin peroxidase isoenzymes. Kinetics and effect of H2O2. Ollikka, P., Harjunpää, T., Palmu, K., Mäntsälä, P., Suominen, I. Appl. Biochem. Biotechnol. (1998) [Pubmed]
  11. Nuclear stains with soluble metachrome metal mordant dye lakes. The effect of chemical endgroup blocking reactions and the artificial introduction of acid groups into tissues. Lillie, R.D., Pizzolato, P., Donaldson, P.T. Histochemistry (1976) [Pubmed]
  12. Synthetic dye decolorization capacity of white rot fungus Dichomitus squalens. Eichlerová, I., Homolka, L., Nerud, F. Bioresour. Technol. (2006) [Pubmed]
  13. New tetrachromic VOF stain (Type III-G.S) for normal and pathological fish tissues. Sarasquete, C., Gutiérrez, M. European journal of histochemistry : EJH. (2005) [Pubmed]
  14. Comparison of morphology and microstructural components of hepatic portal vein between human and pig. Zhang, Y., Huang, T., Wang, P., Li, W., Yu, M. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
  15. Decolorization of orange G by Pleurotus ostreatus monokaryotic isolates with different laccase activity. Eichlerová, I., Homolka, L., Nerud, F. Folia Microbiol. (Praha) (2003) [Pubmed]
  16. Zero-valent iron pretreatment for enhancing the biodegradability of Azo dyes. Perey, J.R., Chiu, P.C., Huang, C.P., Cha, D.K. Water Environ. Res. (2002) [Pubmed]
  17. Adsorption kinetics and thermodynamics of acid dyes on a carboxymethylated chitosan-conjugated magnetic nano-adsorbent. Chang, Y.C., Chen, D.H. Macromolecular bioscience. (2005) [Pubmed]
  18. A new principle in polychrome staining: a system of automated staining, complementary to hematoxylin and eosin, and usable as a research tool. Shoobridge, M.P. Stain technology. (1983) [Pubmed]
  19. Efficacy of a modified Ultra Fast Papanicolaou (UFP) stain for breast aspirates. Kamal, M.M., Bodele, A., Munshi, M.M., Bobhate, S.K., Kher, A.V. Indian journal of pathology & microbiology. (2000) [Pubmed]
  20. Analysis of low-molecular-mass proteins in cerebrospinal fluid by sodium dodecyl sulfate capillary gel electrophoresis. Hiraoka, A., Arato, T., Tominaga, I., Eguchi, N., Oda, H., Urade, Y. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  21. Sensitive indirect photometric detection of inorganic and small organic anions by capillary electrophoresis using Orange G as a probe ion. Johns, C., Shaw, M.J., Macke, M., Haddad, P.R. Electrophoresis (2003) [Pubmed]
  22. Hypothalamo-adenohypophyseal-thyroid interrelationships in the chick embryo. IV. Immunocytochemical demonstration of TSH in the hypophyseal pars distalis. Thommes, R.C., Martens, J.B., Hopkins, W.E., Caliendo, J., Sorrentino, M.J., Woods, J.E. Gen. Comp. Endocrinol. (1983) [Pubmed]
  23. Efficacy of a modified ultrafast Papanicolaou (UFP) stain for breast aspirates. Bandlish, U., Kapoor, K., Shukla, S. Journal of the Indian Medical Association. (2004) [Pubmed]
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