Disease relevance of Robenidine

• Robenidine protected chickens against cecal coccidiosis infections initiated by a strain of the parasite that had no previous exposure to drugs [1].
• The decrease in mortality, in the severity of lesions and oocyst output and the increase in the average weight gain of infected chickens followed closely the increase in the level of robenidine in feed [2].
• Chemotherapy of experimental toxoplasmosis with special reference to robenidine [3].
• Inoculation of 0.09-9.75 mg robenidine/egg, 0.06-6.75 mg salinomycin/egg or 0.08-8.25 mg arprinocid/egg into the yolk sac of 7 days old embryos caused a dose-dependent fetal death [4].

High impact information on Robenidine

• These results suggest that robenidine may stimulate the enterocyte basolateral membrane flux of sugars and neutral amino acids [5].
• Because its action is restricted to the small intestine, the present work addresses the question whether robenidine affects the growth of the animals, sugar and amino acid intestinal transport and membrane-bound intestinal digestion [5].
• Resistance to robenidine developed more readily in experiments using larger numbers of birds with higher numbers of oocysts in the inoculum [6].
• Nicarbazin, halofuginone, and robenidine, when included in the starter feed for 3 wk, were effective in preventing lesions due to Eimeria [7].
• Efficacy of diclazuril against robenidine resistant Eimeria magna in rabbits [8].

Chemical compound and disease context of Robenidine

• Activity of clopidol/methylbenzoquate, robenidine and salinomycin against hepatic coccidiosis in rabbits [9].

Biological context of Robenidine

• Metabolic fate and pharmacokinetics of tissue residues of the anticoccidial drug robenidine in the rabbit. Incidence of coprophagy on its bioavailability [10].
• Drug resistance in coccidia: a robenidine-resistant strain of eimeria tenella [2].

Anatomical context of Robenidine

• Arprinocid was the most lethal to chicken fetuses, followed by salinomycin while robenidine was the least [4].
• The tests showed that the strain of E. tenella could establish infections in chickens medicated with fourfold the recommended level of robenidine in feed but no oocysts could be recovered from the feces of infected chickens when the level of drug was increased to eightfold [2].
• Common carp fingerlings fed diclazuril, lasalocid, robenidine HCl or maduramicin and killed on day 14 after exposure were free from infection, while other groups treated with amprolium, toltrazuril, monensin Na, narasin or salinomycin Na harboured oocysts in the mucus and epithelium of the gut [11].

Associations of Robenidine with other chemical compounds

• In 1982, the year of introduction of the anticoccidial robenidine in commercial rabbit feeds, a dramatic decrease of coccidial infection ratio was detected in commercial rabbitries: only 6% of samples contained greater than 100 oocysts per gram against 85% in 1979, when sulphaquinoxaline/pyrimethamine was used [12].
• Experimental development of resistance to decoquinate and robenidine in a multiple drug-resistant strain of Eimeria necatrix [13].

References