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Chemical Compound Review

Clinacox     2-(4-chlorophenyl)-2-[2,6- dichloro-4-(3,5...

Synonyms: Vecoxan, DICLAZURIL, Nuoqiu, Diclazurilo, Diclazurilum, ...
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Disease relevance of DICLAZURIL


High impact information on DICLAZURIL

  • The method has been successfully used for the quantitative determination of diclazuril in plasma samples from treated sheep, demonstrating the usefulness of the developed method for application in the field of pharmacology and pharmacokinetics [6].
  • Diclazuril was then isolated by means of solid-phase extraction with a cartridge containing a C18 phase [7].
  • The pathogenicity of diclazuril- and amprolium-resistant lines of E. tenella was lower than that of the parental line [8].
  • Reduced weight gain and diarrhoea caused by Isospora suis was controlled by a single application of Toltra in the pre-patent period, while neither diclazuril nor sulphadimidine improved the clinical picture of isosporosis [9].
  • The efficacies of 20 mg/kg body weight (BW) of toltrazuril (Toltra) 2 days post-infection (dpi), 2 mg/kg BW of diclazuril 2 and 3 dpi and 200 mg/kg BW of sulphadimidine 2, 3 and 4 dpi were compared in a model for piglet isosporosis [9].

Chemical compound and disease context of DICLAZURIL


Biological context of DICLAZURIL


Anatomical context of DICLAZURIL


Associations of DICLAZURIL with other chemical compounds


Analytical, diagnostic and therapeutic context of DICLAZURIL


  1. Diclazuril for cryptosporidiosis in AIDS. Menichetti, F., Moretti, M.V., Marroni, M., Papili, R., Di Candilo, F. Am. J. Med. (1991) [Pubmed]
  2. Use of diclazuril for the treatment of isosporiasis in patients with AIDS. Limson-Pobre, R.N., Merrick, S., Gruen, D., Soave, R. Clin. Infect. Dis. (1995) [Pubmed]
  3. Economic benefits of prophylaxis with diclazuril against subclinical coccidiosis in lambs reared indoors. Alzieu, J.P., Mage, C., Maes, L., de Mûelenaere, C. Vet. Rec. (1999) [Pubmed]
  4. Anticoccidial efficacy of diclazuril in pheasants. Vanparijs, O., Hermans, L., Marsboom, R. Vet. Rec. (1990) [Pubmed]
  5. Determination of the activity of diclazuril against Sarcocystis neurona and Sarcocystis falcatula in cell cultures. Lindsay, D.S., Dubey, J.P. J. Parasitol. (2000) [Pubmed]
  6. Quantitative analysis of diclazuril in animal plasma by liquid chromatography/electrospray ionization mass spectrometry. Croubels, S., Cherlet, M., De Backer, P. Rapid Commun. Mass Spectrom. (2002) [Pubmed]
  7. Determination of diclazuril in animal feed by liquid chromatography. De Kock, J., De Smet, M., Sneyers, R. J. Chromatogr. (1992) [Pubmed]
  8. Eimeria tenella, E. acervulina and E. maxima: studies on the development of resistance to diclazuril and other anticoccidial drugs in the chicken. Chapman, H.D. Parasitology (1989) [Pubmed]
  9. Efficacy of various anticoccidials against experimental porcine neonatal isosporosis. Mundt, H.C., Mundt-W??stenberg, S., Daugschies, A., Joachim, A. Parasitol. Res. (2007) [Pubmed]
  10. The efficacy and economic benefits of Supercox((R)), a live anticoccidial vaccine in a commercial trial in broiler chickens in China. Suo, X., Zhang, J.X., Li, Z.G., Yang, C.T., Min, Q.R., Xu, L.T., Liu, Q., Zhu, X.Q. Vet. Parasitol. (2006) [Pubmed]
  11. Control of coccidiosis in turkeys with diclazuril and monensin: effects upon performance and development of immunity to Eimeria species. Chapman, H.D., Matsler, P.L., Chapman, M.E. Avian Dis. (2004) [Pubmed]
  12. In vivo action of the anticoccidial diclazuril (Clinacox) on the developmental stages of Eimeria tenella: an ultrastructural evaluation. Verheyen, A., Maes, L., Coussement, W., Vanparijs, O., Lauwers, F., Vlaminckx, E., Borgers, M., Marsboom, R. J. Parasitol. (1988) [Pubmed]
  13. Histopathological observations on the activity of diclazuril (Vecoxan) against the endogenous stages of Eimeria crandallis in sheep. Taylor, M.A., Catchpole, J., Marshall, J., Marshall, R.N., Hoeben, D. Vet. Parasitol. (2003) [Pubmed]
  14. The use of diclazuril in extended withdrawal anticoccidial programs: 2. Immunity to Eimeria tenella challenge after drug withdrawal. Conway, D.P., Mathis, G.F., Lang, M. Poult. Sci. (2002) [Pubmed]
  15. Epidemiology of Eimeria infections in an Austrian milking sheep flock and control with diclazuril. Platzer, B., Prosl, H., Cieslicki, M., Joachim, A. Vet. Parasitol. (2005) [Pubmed]
  16. New therapeutic approaches for equine protozoal myeloencephalitis: pharmacokinetics of diclazuril sodium salts in horses. Dirikolu, L., Karpiesiuk, W., Lehner, A.F., Hughes, C., Woods, W.E., Harkins, J.D., Boyles, J., Atkinson, A., Granstrom, D.E., Tobin, T. Vet. Ther. (2006) [Pubmed]
  17. Diclazuril preventive therapy of gamma interferon knockout mice fed Sarcocystis neurona sporocysts. Dubey, J.P., Fritz, D., Lindsay, D.S., Shen, S.K., Kwok, O.C., Thompson, K.C. Vet. Parasitol. (2001) [Pubmed]
  18. Activity of diclazuril against Toxoplasma gondii in cultured cells and mice. Lindsay, D.S., Blagburn, B.L. Am. J. Vet. Res. (1994) [Pubmed]
  19. Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae). Molnár, K., Ostoros, G. Acta Vet. Hung. (2007) [Pubmed]
  20. Activity of toltrazuril and diclazuril against Isospora species in kittens and puppies. Lloyd, S., Smith, J. Vet. Rec. (2001) [Pubmed]
  21. Studies on the efficacy of toltrazuril, diclazuril and sulphadimidine against artificial infections with Isospora suis in piglets. Mundt, H.C., Daugschies, A., Wüstenberg, S., Zimmermann, M. Parasitol. Res. (2003) [Pubmed]
  22. Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry. Dubois, M., Pierret, G., Delahaut, P. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  23. Diclazuril, a new broad spectrum anticoccidial drug in chickens. 2. Battery trials. Vanparijs, O., Marsboom, R., Hermans, L., Van der Flaes, L. Poult. Sci. (1989) [Pubmed]
  24. Ultrastructural effects of diclazuril against Toxoplasma gondii and investigation of a diclazuril-resistant mutant. Lindsay, D.S., Rippey, N.S., Toivio-Kinnucan, M.A., Blagburn, B.L. J. Parasitol. (1995) [Pubmed]
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