Disease relevance of Deccox

• Effects of intermittent and continuous administration of decoquinate on bovine coccidiosis in male calves [1].
• Each experiment was a 3 X 3 Latin-square design with treatments being 0, .5 and 5 mg decoquinate/kg body weight [2].
• Effect of different decoquinate treatments on cryptosporidiosis in naturally infected cashmere goat kids [3].
• Decoquinate and the control of experimental ovine toxoplasmosis [4].
• Evaluation of decoquinate, lasalocid, and monensin against experimentally induced sarcocystosis in calves [5].

High impact information on Deccox

• Inhibition of electron transport by decoquinate and clopidol has been studied in mitochondria isolated from unsporulated oocysts of the same lines of E. tenella as those used in the in vivo studies [6].
• Effects of decoquinate and clopidol on electron transport in mitochondria of Eimeria tenella (Apicomplexa: Coccidia) [6].
• Mitochondrial electron transport that is more resistant to inhibition by decoquinate exhibits greater sensitivity to cyanide and azide; electron transport that is more resistant to inhibition by clopidol exhibits a decreased sensitivity to cyanide and azide [6].
• Effect of the quinolone coccidiostat decoquinate on the rearrangement of chromosomes of Eimeria tenella [7].
• Decoquinate-resistance was evident in several species during the rearing of the first decoquinate-medicated crop on each farm, although clinical coccidiosis did not occur [8].

Chemical compound and disease context of Deccox

• Efficacy of lasalocid and decoquinate against coccidiosis in naturally infected dairy calves [9].
• After 30 days of decoquinate feeding, half of the cattle in each group received 5 daily IM injections of dexamethasone (0.04 mg/kg of body weight) [10].
• Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves [11].
• Three experiments utilizing three Holstein steers (235 and 299 kg avg body weight for Exp. 1 and 2, respectively) were conducted to evaluate the effects of decoquinate, a synthetic coccidiostat, on ruminal fermentation, diet digestibility and performance of steers fed a finishing diet containing monensin and tylosin [2].

Biological context of Deccox

• Combinations of low concentrations of decoquinate and clopidol caused a greater inhibition of electron transport than expected from summation of their individual actions [6].
• This treatment also reduced the placental damage caused by the parasite, lengthened the mean gestation period and increased the number and weight of live lambs, in comparison with ewes not fed decoquinate but challenged with T gondii oocysts [4].
• Tracing the emergence of drug-resistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with decoquinate for the first time in the United Kingdom [8].
• A line of Eimeria tenella (H) resistant to robenidine, decoquinate and amprolium has been produced by genetic recombination [12].

Anatomical context of Deccox

• The results showed that continuous medication with decoquinate was effective in preventing the transfer of sporozoites from the intestine to the liver [13].
• All calves, except 2 controls necropsied 14 DAI and 4 calves given decoquinate, discharged moderate-to-large numbers of oocysts in feces and had moderate-to-serve changes in fecal consistency [14].
• We examined human foreskin fibroblast cell cultures infected with the normally tissue cyst-less RH strain of Toxoplasma gondii and treated with decoquinate for evidence of tissue cyst induction and formation [15].
• Lymphocytes from steers of the decoquinate-fed group had decreased random migration under agarose, enhanced cytochrome C reduction, and enhanced iodination activity [10].

Associations of Deccox with other chemical compounds

• Induced resistance to either decoquinate or clopidol resulted in an increased sensitivity of electron transport to inhibition by the other drug [6].
• During the medication period, qualitative oocyst shedding (all species, Eimeria bovis, E zuernii, species other than E bovis and E zuernii) was greater in controls than in either lasalocid-or decoquinate-treated groups [16].
• Evaluation of lasalocid as a coccidiostat in calves: titration, efficacy, and comparison with monensin and decoquinate [17].
• Effects of inoculations with Eimeria zuernii on young calves treated with decoquinate or narasin with or without dexamethasone [14].
• Group A kids were kept as nonmedicated controls and group B kids were orally medicated with 2.5 mg/kg/day of decoquinate (Deccox L. Rhône Poulenc Animal Nutrition) for 21 days from D-3 to D17 [18].

Gene context of Deccox

• Cytochrome b mutation identified in a decoquinate-resistant mutant of Toxoplasma gondii [19].

Analytical, diagnostic and therapeutic context of Deccox

• Activity of decoquinate against Cryptosporidium parvum in cell cultures and neonatal mice [20].
• Transmission electron microscopy observations demonstrated tissue cysts in decoquinate-treated cultures on days 3, 4, 5, and 6 after inoculation [15].
• Vaccination of sheep with the live vaccine is an effective preventive measure and the use of decoquinate in feed may be useful in some situations [21].
• OBJECTIVE: To evaluate the effect of daily oral administration of decoquinate to neonatal calves experimentally challenged with various numbers of Cryptosporidium parvum oocysts [22].
• Treatment groups included an unmedicated control group, lasalocid at 1 mg/kg of BW, decoquinate at .5 mg/kg of BW, or lasalocid plus decoquinate [9].

References