Disease relevance of Maduramicin

• Some toxicity, as demonstrated by weight loss, was observed with both maduramicin and alborixin [1].
• Maduramicin was also evaluated in a relapsing model of cryptosporidiosis in which the infection was observed to recur after treatments were discontinued [1].
• Two polyether ionophores, maduramicin and alborixin, were evaluated for anticryptosporidial activity in a severe combined immune deficient (SCID) mouse model of cryptosporidiosis [1].
• Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions [2].
• Average weight gain and feed conversion at 10 weeks were significantly improved over unmedicated infected controls when maduramicin ammonium was given at 5-7 ppm [2].

High impact information on Maduramicin

• Eimeria parasites were isolated from Nanhai Guangdong province (southern China) and studied in chickens in wire cages to evaluate their drug resistance against commonly used ionophores: monensin (100 mg/kg of feed), lasolacid (90 mg/kg), salinomycin (60 mg/kg), maduramicin (5 mg/kg) and semduramicin (25 mg/kg) [3].
• Clinico-haematological and mineral studies on experimental maduramicin toxicity in chickens [4].
• Maduramicin medication caused significant reduction in haemoglobin in both the medicated group from day 14 and total erythrocyte count and packed cell volume in 10 ppm group on day 21 [4].
• Development of an ELISA for maduramicin and determination of the depletion kinetics of maduramicin residues in poultry [5].
• Feed and water consumption and performance of male and female broilers fed salinomycin and maduramicin followed by a withdrawal ration [6].

Chemical compound and disease context of Maduramicin

• The effects of the growth promoters avoparcin and avilamycin and the ionophore anticoccidials maduramicin, narasin and monensin on the growth of Clostridium perfringens (Cp) in the caeca and on performance of broiler chickens were tested in 2 experiments [7].

Biological context of Maduramicin

• Three Eimeria tenella field isolates from Gurgaon district of Haryana (north India) were studied in a battery test for evaluating drug resistance against two currently used ionophores; maduramicin (5ppm) and salinomycin (60ppm) [8].
• These results are consistent with the initial formation of a triene, which is converted to maduramicin by cyclization of the triepoxide [9].
• Chemistry of maduramicin. II. Decarboxylation, abnormal ketalization and dehydration [10].
• Cardiomyopathy of ruminants induced by the litter of poultry fed on rations containing the ionophore antibiotic, maduramicin. I. Epidemiology, clinical signs and clinical pathology [11].

Anatomical context of Maduramicin

• Two groups of 24 three-day-old turkeys each were inoculated with Eimeria meleagrimitis sporulated oocytes and fed a diet containing respectively 5 and 6 ppm of maduramicin ammonium [12].
• Common carp fingerlings fed diclazuril, lasalocid, robenidine HCl or maduramicin and killed on day 14 after exposure were free from infection, while other groups treated with amprolium, toltrazuril, monensin Na, narasin or salinomycin Na harboured oocysts in the mucus and epithelium of the gut [13].

Associations of Maduramicin with other chemical compounds

• Monensin, lasalocid, salinomycin, narasin and maduramicin are carboxylic ionophores intended for use as anticoccidial drugs for poultry and as growth promotants for ruminants [14].

Gene context of Maduramicin

• Fast atom bombardment mass spectrometry (FAB MS) and fast atom bombardment mass spectrometry-mass spectrometry (FAB MS/MS) were used to study the monovalent glycoside polyether antibiotics maduramicin alpha, beta and delta and the maduramicin alpha salts, their derivatives and degradation products [15].

Analytical, diagnostic and therapeutic context of Maduramicin

• Determination of maduramicin ammonium in poultry feedstuffs by high-performance liquid chromatography [16].
• Development of an enzyme-linked immunosorbent assay for the determination of maduramicin in broiler chicken tissues [17].

References