Disease relevance of FELYPRESSIN

• In group A 1% prilocaine with felypressin was used as the local anaesthetic agent in a volume of 0.25 ml/kg body weight [1].
• Hemodynamic changes were evaluated in patients with essential hypertension when felypressin of various concentrations was administered [2].
• Just before the start of the surgery, severe and persistent hypotension with tachycardia after local injection of 3% propitocaine with 0.03 IU/mL felypressin (Citanest-Octapressin) was followed by sudden ST elevations in the ECG [3].
• Felypressin and AVP induced a pressor effect, and bradycardia was inhibited by IV V1 antagonist [4].

High impact information on FELYPRESSIN

• In group B 3% prilocaine with felypressin was used in a volume of 0.08 ml/kg body weight (i.e. equal total drug dosages) [1].
• Arginine vasopressin, felypressin and desmopressins in concentrations considerably lower than those necessary to elicit directly the release of ACTH, potentiated, in a dose-related manner, the activity of CRF-41 in vitro [5].
• Angiotensin II and felypressin, also depressed under these conditions the elevation of plasma renin concentration caused by adrenalectomy [6].
• Comparative effects of adrenaline and felypressin (octapressin) on consecutive sections of the vascular bed in canine adipose tissue [7].
• Lidocaine with epinephrine and prilocaine with felypressin were effective in significantly inhibiting adhesion, chemotaxis, phagocytosis, and the production of hydrogen peroxide by neutrophils and macrophages [8].

Biological context of FELYPRESSIN

• Significant increase of blood pressure and decrease in 1/PEP2 was noted upon administration of 3 ml of anesthetic solution containing 0.13 IU/ml of felypressin [2].
• The influence of desipramine on the blood pressure elevation and heart rate stimulation by levonordefrin and felypressin alone and in the presence of local anaesthetics [9].
• It is therefore suggested that a mixture of felypressin and adrenaline be used in local anaesthetic solutions in order to provide more effective vasoconstriction [10].
• In contrast to the vasopressin, felypressin (contained in prilocaine), epinephrine (contained in lidocaine) caused an acceleration of cardiac function--increased heart rate, cardiac output, 1/pre-ejection period (PEP), and aortic pulse wave velocity and decreased PEP and left ventricular ejection time [11].

Anatomical context of FELYPRESSIN

• The present investigations in cats were designed to study the effects of local anaesthetics containing adrenaline and felypressin (octapressin) on dental pulp function [12].
• No ischemic change of the myocardium was detected even with the highest felypressin concentration (3 ml of 2% propitocaine containing 0.25 IU/ml of felypressin) [2].
• OBJECTIVE: To test the hypothesis that prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline when performing large loop excision of the transformation zone of the cervix [13].

Associations of FELYPRESSIN with other chemical compounds

• The effects of i.v. infused (asp1-beta-amid, val5)-angiotensin II (1 mug/kg min), felypressin (phen2, lys8-vasopressin) (40 mU/kg min) and phenylephrine (30 mug/kg min) were investigated on the increase in plasma renin concentration [6].
• The effects of felypressin, a synthetic vasoconstrictor, upon arterial blood pressure and heart are lesser than those of norepinephrine or epinephrine, but due to its effects like oxytocin these catecholamines are yet the most used vasoconstrictors in association with lidocaine or another anesthetic salt [14].

References