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Chemical Compound Review

Ginsenoside rb1     (2R,3R,4S,5R,6R)-2-[2- [(3S,8R,10S,13R)-3...

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Disease relevance of Ginsenoside rb1


High impact information on Ginsenoside rb1


Biological context of Ginsenoside rb1


Anatomical context of Ginsenoside rb1


Associations of Ginsenoside rb1 with other chemical compounds


Gene context of Ginsenoside rb1

  • We have examined the possibility that a component of Panax ginseng, ginsenoside-Rb1, acts by binding to estrogen receptor [2].
  • Dose-response experiments revealed that ginsenoside-Rb1 was the most active compound and it completely blocked PTK activation at a wide range of concentrations [13].
  • Ginsenoside-Rb1, Rc, Re and Rg, inhibited the TH activity by 51.5, 25.4, 31.3, 44.3 and 43.3%, respectively, at a concentration of 80 microg/ml [14].

Analytical, diagnostic and therapeutic context of Ginsenoside rb1

  • Blood samples were collected at several time intervals following intravenous injection of ginsenoside-Rb1 [12].
  • Neither GRb1-m nor GRb1 (1-30 microM) changed the prolongation effect of NGF, nor did NGF show a significant effect on the neurite elongation and re-elongation after axotomy by laser beam irradiation [10].


  1. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Hasegawa, H., Sung, J.H., Benno, Y. Planta Med. (1997) [Pubmed]
  2. Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Lee, Y.J., Jin, Y.R., Lim, W.C., Park, W.K., Cho, J.Y., Jang, S., Lee, S.K. Arch. Pharm. Res. (2003) [Pubmed]
  3. Effect of ginsenoside-Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats. Guan, L., Li, W., Liu, Z. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2002) [Pubmed]
  4. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. Cho, J., Park, W., Lee, S., Ahn, W., Lee, Y. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  5. Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate-induced cyclooxygenase-2 promoter. Park, W., Lim, W., Cho, J., Inoue, H., Rhyu, M.R., Lee, Y. Planta Med. (2006) [Pubmed]
  6. Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Motoo, Y., Sawabu, N. Cancer Lett. (1994) [Pubmed]
  7. Isolation and characterization of ginsenoside-Rg2, 20R-prosapogenin, 20S-prosapogenin and delta 20-prosapogenin. Chemical studies on saponins of Panax ginseng C. A. Meyer, Third report. Kaku, T., Kawashima, Y. Arzneimittel-Forschung. (1980) [Pubmed]
  8. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Karikura, M., Miyase, T., Tanizawa, H., Taniyama, T., Takino, Y. Chem. Pharm. Bull. (1991) [Pubmed]
  9. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Himi, T., Saito, H., Nishiyama, N. Chem. Pharm. Bull. (1989) [Pubmed]
  10. Malonylginsenoside Rb1 potentiates nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia. Nishiyama, N., Cho, S.I., Kitagawa, I., Saito, H. Biol. Pharm. Bull. (1994) [Pubmed]
  11. Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. Park, Y.C., Lee, C.H., Kang, H.S., Kim, K.W., Chung, H.T., Kim, H.D. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  12. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Tsai, S.C., Chiao, Y.C., Lu, C.C., Wang, P.S. The Chinese journal of physiology. (2003) [Pubmed]
  13. The inhibitory effects of ginsenosides on protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells. Dou, D.Q., Zhang, Y.W., Zhang, L., Chen, Y.J., Yao, X.S. Planta Med. (2001) [Pubmed]
  14. Effects of ginsenosides on bovine adrenal tyrosine hydroxylase. Kim, H.S., Zhang, Y.H., Fang, L.H., Lee, M.K. Journal of ethnopharmacology. (1999) [Pubmed]
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