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Chemical Compound Review

Cheladrate     disodium 2-[2-(carboxylatomethyl...

Synonyms: Chelaplex III, Complexon III, Chelaton III, Endrate (TN), AG-G-37723, ...
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Disease relevance of Edathamil


High impact information on Edathamil


Chemical compound and disease context of Edathamil


Biological context of Edathamil


Anatomical context of Edathamil


Associations of Edathamil with other chemical compounds

  • Diprivan contains disodium edetate and has a pH of 7-8.5, while the Gensia product contains sodium metabisulphite and is formulated to a pH of 4.5-6 [18].
  • The application of these methods to autoclaved solutions containing PM nitrate and disodium edetate demonstrates that under the conditions of heat sterilization the phenylmercuric ion is degraded to mercuric ion and benzene to the extent of 15% at pH 8, 80% at pH 7 and completely degraded at pH 5 and 6 [19].

Analytical, diagnostic and therapeutic context of Edathamil


  1. Unmasking of hypoparathyroidism in familial partial DiGeorge syndrome by challenge with disodium edetate. Gidding, S.S., Minciotti, A.L., Langman, C.B. N. Engl. J. Med. (1988) [Pubmed]
  2. Ectopic impulse generation in demyelinated axons: effects of PaCO2, pH, and disodium edetate. Burchiel, K.J. Ann. Neurol. (1981) [Pubmed]
  3. Lowering the calcium concentration in the subretinal space in vivo loosens retinal adhesion. Kita, M., Negi, A., Marmor, M.F. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  4. Electron microscope study of effect of benzalkonium chloride and edetate disodium on cell envelope of Pseudomonas aeruginosa. Richards, R.M., Cavill, R.H. Journal of pharmaceutical sciences. (1976) [Pubmed]
  5. Laryngospasm and paradoxical bronchoconstriction after repeated doses of beta 2-agonists containing edetate disodium. Mutlu, G.M., Moonjelly, E., Chan, L., Olopade, C.O. Mayo Clin. Proc. (2000) [Pubmed]
  6. Detection and treatment of occupational lead nephropathy. Wedeen, R.P., Malik, D.K., Batuman, V. Arch. Intern. Med. (1979) [Pubmed]
  7. An unusual cause of recurrent abdominal pain. Jongnarangsin, K., Mukherjee, S., Bauer, M.A. Am. J. Gastroenterol. (1999) [Pubmed]
  8. Kinin, kininogen and kininase levels during acute Babesia bovis (= B. argentina) infection of cattle. Wright, I.G. Br. J. Pharmacol. (1977) [Pubmed]
  9. Cation metabolism during propofol sedation with and without EDTA in patients with impaired renal function. Barr, J., Zaloga, G.P., Haupt, M.T., Weinmann, M., Murray, M.J., Bandi, V., Teres, D. Intensive care medicine. (2000) [Pubmed]
  10. Inhibition of pseudomonas strains in two soft contact lens soaking solutions. Penner, J.L., Jackson, D.M., Dixon, W.S. Can. J. Ophthalmol. (1976) [Pubmed]
  11. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005. Brown, M.J., Willis, T., Omalu, B., Leiker, R. Pediatrics (2006) [Pubmed]
  12. Effect of edetate disodium and reduced glutathione on absorption of acetazolamide from GI tract of rats. Schoenwald, R.D., Ward, R.L. Journal of pharmaceutical sciences. (1976) [Pubmed]
  13. Does calcium mediate the slowing of gastric emptying in primates? Hunt, J.N., McHugh, P.R. Am. J. Physiol. (1982) [Pubmed]
  14. Edetate disodium-mediated chloramphenicol resistance in Pseudomonas cepacia. Nielsen, P.A., Close, J.A. Journal of pharmaceutical sciences. (1982) [Pubmed]
  15. The effect of pre-treatment of syngeneic mice with tumour cells cultured in vitro on the induction of a transplantable tumour. Pugliese, A., Cavallo, G. Giornale di batteriologia, virologia ed immunologia. (1976) [Pubmed]
  16. Does the presence of unwanted dermal fibroblasts limit the usefullness of autologous epidermal keratinocyte grafts? Drewa, T., Szmytkowska, K., Wlodarczyk, Z., Sir, I., Kierzenkowska-Mila, C. Transplant. Proc. (2006) [Pubmed]
  17. Diagnostic significance of edetate disodium calcium testing in children with increased lead absorption. Saenger, P., Rosen, J.F., Markowitz, M. Am. J. Dis. Child. (1982) [Pubmed]
  18. Physical properties and stability of two emulsion formulations of propofol. Han, J., Davis, S.S., Washington, C. International journal of pharmaceutics. (2001) [Pubmed]
  19. The chemical degradation of phenylmercuric nitrate by disodium edetate during heat sterilization at pH values commonly encountered in ophthalmic products. Parkin, J.E., Duffy, M.B., Loo, C.N. Journal of clinical pharmacy and therapeutics. (1992) [Pubmed]
  20. Quantitative determination of disodium edetate in ophthalmic and contact lens care solutions by reversed-phase high-performance liquid chromatography. Hall, L., Takahashi, L. Journal of pharmaceutical sciences. (1988) [Pubmed]
  21. Polarographic determination of edetate disodium in eyewash and ophthalmic decongestant solutions. Carlson, M., Habeger, L.E. Journal of pharmaceutical sciences. (1980) [Pubmed]
  22. Chelation therapy of atherosclerosis. Rathmann, K.L., Golightly, L.K. Drug intelligence & clinical pharmacy. (1984) [Pubmed]
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