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Chemical Compound Review

Ethriol     2-ethyl-2- (hydroxymethyl)propane-1,3- diol

Synonyms: Ettriol, Etriol, Hexaglycerol, Hexaglycerine, TMP (alcohol), ...
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Disease relevance of TMP


Psychiatry related information on TMP


High impact information on TMP


Biological context of TMP


Anatomical context of TMP


Associations of TMP with other chemical compounds

  • For the mutagenic acrylates/methacrylates, primarily small-colony, trifluorothymidine (TFT)-resistant mutants were induced, suggesting a clastogenic mechanism that was supported by increased aberrations and micronucleus frequencies (except for trimethylolpropane trimethacrylate which was positive for aberration but not micronucleus induction) [13].
  • The study on the changes in fluorescence intensity and spectroscopic shifts of studied compounds were carried out during thermally initiated polymerization of methyl methacrylate (MMA) and during photoinitiated polymerization of 2-ethyl-2-(hydroxymethyl)propane-1,3-diol triacrylate (TMPTA) [14].
  • MIL-L-23699 lubricants that are composed principally of trimethylolpropane triheptanoate (TMP) and tricresyl phosphate (TCP) have been shown to form a neurotoxicant, trimethylolpropane phosphate (TMPP), during pyrolysis and/or combustion [15].

Gene context of TMP

  • Various photocurable liquid biodegradable trimethylene carbonate (TMC)-based (co)oligomers were prepared by ring-opening (co)polymerization of TMC with or without L-lactide (LL) using low molecular weight poly(ethylene glycol) (PEG) (mol wt 200, 600, or 1000) or trimethylolpropane (TMP) as an initiator [2].

Analytical, diagnostic and therapeutic context of TMP

  • OBJECTIVE: The purpose of this study was to prepare a light-cured adhesive applicable for orthodontics by mixing monomers and a polymerized reactive organic composite filler (prepolymerized trimethylolpropane trimethacrylate-filler, TMPT-filler) [16].
  • The effect of a single subconvulsive dose of the GABAergic convulsant trimethylolpropane phosphate (TMPP) on gene expression in total rat brain was examined using cDNA array analysis [17].


  1. Genotoxicity of multifunctional acrylates in the Salmonella/mammalian-microsome assay and mouse lymphoma TK+/-assay. Cameron, T.P., Rogers-Back, A.M., Lawlor, T.E., Harbell, J.W., Seifried, H.E., Dunkel, V.C. Environ. Mol. Mutagen. (1991) [Pubmed]
  2. Photocurable biodegradable liquid copolymers: synthesis of acrylate-end-capped trimethylene carbonate-based prepolymers, photocuring, and hydrolysis. Matsuda, T., Kwon, I.K., Kidoaki, S. Biomacromolecules (2004) [Pubmed]
  3. Trimethylolpropane phosphate (TMPP) perfusion into the nucleus accumbens of the rat: electroencephalographic, behavioral and neurochemical correlates. Lindsey, J.W., Prues, S.L., Alva, C., Ritchie, G.D., Rossi, J. Neurotoxicology (1998) [Pubmed]
  4. Fetal and neonatal exposure to trimethylolpropane phosphate alters rat social behavior and emotional responsivity. Bekkedal, M.Y., Rossi, J., Panksepp, J. Neurotoxicology and teratology. (1999) [Pubmed]
  5. Nanoparticle-based continuous full filling capillary electrochromatography/electrospray ionization-mass spectrometry for separation of neutral compounds. Nilsson, C., Viberg, P., Spégel, P., Jörntén-Karlsson, M., Petersson, P., Nilsson, S. Anal. Chem. (2006) [Pubmed]
  6. Photo-polymerized microarchitectural constructs prepared by microstereolithography (muSL) using liquid acrylate-end-capped trimethylene carbonate-based prepolymers. Kwon, I.K., Matsuda, T. Biomaterials (2005) [Pubmed]
  7. Using paramagnetic particles as repulsive templates for the preparation of membranes of controlled porosity. Tierno, P., Thonke, K., Goedel, W.A. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  8. Affinity depletion of albumin from human cerebrospinal fluid using Cibacron-blue-3G-A-derivatized photopatterned copolymer in a microfluidic device. Li, C., Lee, K.H. Anal. Biochem. (2004) [Pubmed]
  9. Identification of differential gene expression profiles in rat cortical cells exposed to the neuroactive agents trimethylolpropane phosphate and bicuculline. Andreadis, J.D., Mann, T.T., Russell, A.C., Stenger, D.A., Pancrazio, J.J. Biosensors & bioelectronics. (2001) [Pubmed]
  10. Tissue distribution, metabolism, and clearance of the convulsant trimethylolpropane phosphate in rats. Rossi, J., Jung, A.E., Ritchie, G.D., Lindsey, J.W., Nordholm, A.F. Drug Metab. Dispos. (1998) [Pubmed]
  11. Trimethylolpropane phosphate induces epileptiform discharges in the CA1 region of the rat hippocampus. Lin, J., Ritchie, G.D., Stenger, D.A., Nordholm, A.F., Pancrazio, J.J., Rossi, J. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  12. Repeated exposure to trimethylolpropane phosphate induces central nervous system sensitization and facilitates electrical kindling. Lin, J., Cassell, J., Ritchie, G.D., Rossi, J., Nordholm, A.F. Physiol. Behav. (1998) [Pubmed]
  13. Analysis of the genotoxicity of nine acrylate/methacrylate compounds in L5178Y mouse lymphoma cells. Dearfield, K.L., Millis, C.S., Harrington-Brock, K., Doerr, C.L., Moore, M.M. Mutagenesis (1989) [Pubmed]
  14. Stilbene-like molecules as fluorescent probes applied for monitoring of polymerization process. Kabatc, J., Jedrzejewska, B., Bajorek, A., Paczkowski, J. Journal of fluorescence. (2006) [Pubmed]
  15. Evaluation of shipboard formation of a neurotoxicant (trimethylolpropane phosphate) from thermal decomposition of synthetic aircraft engine lubricant. Wyman, J., Pitzer, E., Williams, F., Rivera, J., Durkin, A., Gehringer, J., Servé, P., von Minden, D., Macys, D. American Industrial Hygiene Association journal. (1993) [Pubmed]
  16. Preparation of an effective light-cured bonding agent for orthodontic application. Gunadi, G., Nakabayashi, N. Dental materials : official publication of the Academy of Dental Materials. (1997) [Pubmed]
  17. Gene modulation in total brain induced by exposure to the bicyclic phosphorus ester trimethylolpropane phosphate (TMPP). Russell, A.C., Bekkedal, M.Y., Mann, T.T., Ritchie, G.D., Rossi, J., Stenger, D.A., Pancrazio, J.J., Andreadis, J.D. Neurotoxicology (2002) [Pubmed]
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