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Chemical Compound Review

Torbafilina     7-(ethoxymethyl)-1-(5- hydroxy-5-methyl...

Synonyms: Torbafylline, Torbafyllinum, SureCN93832, CHEMBL2104934, AC1L246H, ...
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Disease relevance of Torbafylline

  • Effects of torbafylline on muscle atrophy: prevention and recovery [1].
  • Torbafylline might thus prove effective in stimulating muscle regeneration in myopathy [2].
  • These data indicate a possible role for torbafylline as an adjunct to exercise therapy for chronic muscle ischemia [3].
  • Torbafylline treatment had little further effect on ischemic muscles subjected to mild stimulation, which on its own improved functional hyperemia, resistance to fatigue, and the capillaries per fibre ratio in tibialis anterior, although it did significantly increase the capillary per fibre ratio in extensor digitorum longus [3].
  • The effects of torbafylline [7-ethoxymethyl-1-(5-hydroxy-5-methylhexyl)3-methylxanthine] on the above parameters were studied after chronic oral gavage (25 mg/kg body weight per day); treatment started the day after surgery and the last drug application was performed the day of the final experiments [4].

High impact information on Torbafylline


Chemical compound and disease context of Torbafylline


Biological context of Torbafylline


Anatomical context of Torbafylline


Associations of Torbafylline with other chemical compounds


Analytical, diagnostic and therapeutic context of Torbafylline

  • 3. The percentage of glycolytic fibres was not changed by ligation, but it decreased significantly in animals treated with torbafylline [16].


  1. Effects of torbafylline on muscle atrophy: prevention and recovery. Aboudrar, S., Desplanches, D., Graber-von Bergen, F., Favier, R., Okyayuz-Baklouti, I., Hoppeler, H. Can. J. Physiol. Pharmacol. (1992) [Pubmed]
  2. Effect of torbafylline on mitochondrial calmitine in mouse skeletal muscle regeneration after injection of a myotoxic drug. Lucas-Héron, B., Ollivier, B., Schmitt, N. J. Neurol. Sci. (1993) [Pubmed]
  3. Effect of torbafylline on muscle blood flow, performance, and capillary supply in ischemic muscles subjected to varying levels of activity. Hudlicka, O., Egginton, S., Brown, M.D., Okyayuz-Baklouti, I. Can. J. Physiol. Pharmacol. (1994) [Pubmed]
  4. Correlation of function and energy metabolism in rat ischemic skeletal muscle by 31P-NMR spectroscopy: effects of torbafylline. Koch, H., Okyayuz-Baklouti, I., Norris, D., Kogler, H., Leibfritz, D. Journal of medicine. (1993) [Pubmed]
  5. Torbafylline (HWA 448) inhibits enhanced skeletal muscle ubiquitin-proteasome-dependent proteolysis in cancer and septic rats. Combaret, L., Tilignac, T., Claustre, A., Voisin, L., Taillandier, D., Obled, C., Tanaka, K., Attaix, D. Biochem. J. (2002) [Pubmed]
  6. Influence of pentoxifylline and its derivatives on antibiotic uptake and superoxide generation by human phagocytic cells. Hand, W.L., Hand, D.L. Antimicrob. Agents Chemother. (1995) [Pubmed]
  7. Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration. Kelleher, D.K., Thews, O., Vaupel, P. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  8. The influence of pentoxifylline and torbafylline on muscle blood flow in animals with peripheral arterial insufficiency. Dinn, R.F., Yang, H.T., Terjung, R.L. Journal of clinical pharmacology. (1990) [Pubmed]
  9. The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle. Okyayuz-Baklouti, I. Eur. J. Pharmacol. (1989) [Pubmed]
  10. Role of neutrophils and macrophages in experimental nephrosis of the rat. Berens, K.L., Verani, R.R., Luke, D.R. Renal failure. (1998) [Pubmed]
  11. Modification of cisplatin-induced renal p-aminohippurate uptake alteration and lipid peroxidation by thiols, Ginkgo biloba extract, deferoxamine and torbafylline. Inselmann, G., Blöhmer, A., Kottny, W., Nellessen, U., Hänel, H., Heidemann, H.T. Nephron (1995) [Pubmed]
  12. The effect of torbafylline on enzyme activities in fast and slow muscles with limited blood supply. Egginton, S., Hudlická, O. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1991) [Pubmed]
  13. Skeletal muscle microcirculation: the effects of limited blood supply and treatment with torbafylline. Dawson, J.M., Okyayuz-Baklouti, I., Hudlickà, O. International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation. (1990) [Pubmed]
  14. Collateral circulation in skeletal muscles: effect of pentoxifylline and torbafylline. Hudlicka, O., Torres, S.H. Journal of medicine. (1990) [Pubmed]
  15. Fine structure of capillaries in ischaemic and non ischaemic rat striated muscle. Effect of torbafylline. Egginton, S., Hudlicka, O., Glover, M. International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation. (1993) [Pubmed]
  16. Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply. Hudlická, O., Price, S. Br. J. Pharmacol. (1990) [Pubmed]
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