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Gene Review

GGTA1  -  alpha-galactosyltransferase 1 (glycoprotein)

Bos taurus

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Disease relevance of GGTA1


High impact information on GGTA1


Chemical compound and disease context of GGTA1


Biological context of GGTA1


Anatomical context of GGTA1


Associations of GGTA1 with chemical compounds


Physical interactions of GGTA1

  • The results suggest that cell surface Gal Tase interacts with a form of the EGF-R, having altered carbohydrate moieties to promote intracellular signaling for acinar cell proliferation [19].

Other interactions of GGTA1

  • The influence of compounds that might modulate the reaction was also examined. alpha-Lactalbumin, a modifier of the galactosyltransferase in milk, acted as a competitive inhibitor of the galactosylation of opsin [20].
  • Together, these experiments show that neural crest cells have at least two distinct mechanisms for interacting with the substrate during migration, one that is fibronectin-dependent and one that uses GalTase recognition of basal lamina glycoconjugates [7].
  • A 1.3-kilobase cDNA clone (7A) coding for bovine galactosyltransferase (glycoprotein 4-beta-galactosyltransferase, EC was isolated from a lambda gt11 expression library by immunological screening with monospecific polyclonal antisera to the affinity-purified bovine enzyme [11].
  • The beta-elimination of galactosyltransferase radiolabeled synapsin I and subsequent analysis of released saccharide on high-voltage paper electrophoresis confirmed the presence of monosaccharidic GlcNAc moieties in O-linkage to the protein [21].
  • Galactosyltransferase, assayed as a lactose synthetase, showed a 10-fold greater affinity for glucose when Mn2+ ions were replaced by clupeine or by ribonuclease as cationic activator [22].

Analytical, diagnostic and therapeutic context of GGTA1


  1. Characterization of products synthesized by galactosyltransferase purified from the ascites of ovarian cancer patients. Chatterjee, S.K., Bhattacharya, M., Barlow, J.J. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Virion basic phosphoprotein from human cytomegalovirus contains O-linked N-acetylglucosamine. Benko, D.M., Haltiwanger, R.S., Hart, G.W., Gibson, W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation. Lopez, L.C., Maillet, C.M., Oleszkowicz, K., Shur, B.D. Mol. Cell. Biol. (1989) [Pubmed]
  4. Elevation of glycoprotein galactosyltransferase activity in human lung cancer related to histological types. Kijimoto-Ochiai, S., Makita, A., Kameya, T., Kodama, T., Araki, E., Yoneyama, T. Cancer Res. (1981) [Pubmed]
  5. Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin. Kelly, W.G., Hart, G.W. Cell (1989) [Pubmed]
  6. Isolation and characterization of membranes from bovine liver which are highly enriched in mannose 6-phosphate receptors. Messner, D.J., Griffiths, G., Kornfeld, S. J. Cell Biol. (1989) [Pubmed]
  7. Evidence for a novel enzymatic mechanism of neural crest cell migration on extracellular glycoconjugate matrices. Runyan, R.B., Maxwell, G.D., Shur, B.D. J. Cell Biol. (1986) [Pubmed]
  8. The wbbD gene of E. coli strain VW187 (O7:K1) encodes a UDP-Gal: GlcNAc{alpha}-pyrophosphate-R {beta}1,3-galactosyltransferase involved in the biosynthesis of O7-specific lipopolysaccharide. Riley, J.G., Menggad, M., Montoya-Peleaz, P.J., Szarek, W.A., Marolda, C.L., Valvano, M.A., Schutzbach, J.S., Brockhausen, I. Glycobiology (2005) [Pubmed]
  9. Electrophoretic analysis of glycoprotein glycans produced by lepidopteran insect cells infected with an immediate early recombinant baculovirus encoding mammalian beta1,4-galactosyltransferase. Wolff, M.W., Murhammer, D.W., Jarvis, D.L., Linhardt, R.J. Glycoconj. J. (1999) [Pubmed]
  10. Bovine alpha 1----3-galactosyltransferase: isolation and characterization of a cDNA clone. Identification of homologous sequences in human genomic DNA. Joziasse, D.H., Shaper, J.H., Van den Eijnden, D.H., Van Tunen, A.J., Shaper, N.L. J. Biol. Chem. (1989) [Pubmed]
  11. Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library. Shaper, N.L., Shaper, J.H., Meuth, J.L., Fox, J.L., Chang, H., Kirsch, I.R., Hollis, G.F. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  12. Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase. Narimatsu, H., Sinha, S., Brew, K., Okayama, H., Qasba, P.K. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  13. Enzymic characteristics of fat globule membranes from bovine colostrum and bovine milk. Powell, J.T., Järlfors, U., Brew, K. J. Cell Biol. (1977) [Pubmed]
  14. Localization of galactosyl- and sialyltransferase by immunofluorescence: evidence for different sites. Berger, E.G., Hesford, F.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  15. A comparison of the interactions of galactosyltransferase with a glycoprotein substrate (Ovalbumin) and with alpha-lactalbumin. Powell, J.T., Brew, K. J. Biol. Chem. (1976) [Pubmed]
  16. Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus. Boix, E., Swaminathan, G.J., Zhang, Y., Natesh, R., Brew, K., Acharya, K.R. J. Biol. Chem. (2001) [Pubmed]
  17. Developmental and mutational changes of glycoproteins in the mouse neuronal retina: studies with bovine galactosyltransferase. Wallenfels, B. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  18. An intrinsic membrane glycoprotein with cytosolically oriented n-linked sugars. Pedemonte, C.H., Sachs, G., Kaplan, J.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  19. Rat parotid gland acinar cell proliferation: signal transduction at the plasma membrane. Purushotham, K.R., Nakagawa, Y., Humphreys-Beher, M.G., Maeda, N., Schneyer, C.A. Crit. Rev. Oral Biol. Med. (1993) [Pubmed]
  20. In vitro galactosylation of rhodopsin and opsin: kinetics, properties and characterization. Ju, J.M., Kean, E.L. Exp. Eye Res. (1992) [Pubmed]
  21. Synapsins contain O-linked N-acetylglucosamine. Lüthi, T., Haltiwanger, R.S., Greengard, P., Bähler, M. J. Neurochem. (1991) [Pubmed]
  22. Cationic activation of galactosyltransferase from rat mammary Golgi membranes by polyamines and by basic peptides and proteins. Navaratnam, N., Virk, S.S., Ward, S., Kuhn, N.J. Biochem. J. (1986) [Pubmed]
  23. Purification and characterization of human serum galactosyltransferase (lactose synthetase A protein). Fujita-Yamaguchi, Y., Yoshida, A. J. Biol. Chem. (1981) [Pubmed]
  24. Golgi detection in mitotic and interphase cells by antibodies to secreted galactosyltransferase. Hiller, G., Weber, K. Exp. Cell Res. (1982) [Pubmed]
  25. Circular dichroism changes in galactosyltransferase upon substrate binding;. Geren, C.R., Magee, S.C., Ebner, K.E. Biochemistry (1975) [Pubmed]
  26. Manganese (II) And spin-labeled uridine 5'-diphosphate binding to bovine galactosyltransferase. Berliner, L.J., Wong, S.S. Biochemistry (1975) [Pubmed]
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