Disease relevance of ZOLAZEPAM

• Adult male rats were given a single intraperitoneal injection of Telazol dose at a of 20, 40, 80, or 120 mg/kg body weight (six rats/dose), while control rats received the vehicle only [1].
• There are no studies examining spinal toxicity of Telazol, and further studies are necessary before recommending clinical use of this technique [2].
• We developed a technique using Telazol (13 mg/kg) to anesthetize ducks before surgical biopsy of the liver in ducks infected with duck hepatitis B virus [3].

High impact information on ZOLAZEPAM

• The primary goal of the present study was to determine the constituent of Telazol responsible for the enzyme induction [4].
• Densitometric quantitation of immunoblots probed with polyclonal antibody against cytochrome P450 2B1 indicated a 17-fold increase in the hepatic level of cytochrome P450 2B1 for rats treated with the highest dose of Telazol [1].
• Monkeys were anesthetized during experiments with Telazol, a dissociative agent that has no significant effect on microstimulation-induced eye movement parameters (current threshold, velocity, and duration) [5].
• In the presence of 0.5 mg of anti-cytochrome P450 2B1 IgG/nmol P450, benzyloxyresorufin O-dealkylase activity was inhibited by 92% in hepatic microsomes prepared from a rat treated with Telazol at a dose of 120 mg/kg compared with only 25% inhibition in hepatic microsomes from a control rat [1].
• In macaques, lymphocyte numbers decreased following afternoon injection of Telazol, ketamine or saline [6].

Chemical compound and disease context of ZOLAZEPAM

• Forty seven free-ranging, adult, male koalas were captured and administered an intramuscular injection of the dissociative anaesthetic, Telazol (tiletamine HCl plus zolazepam HCl), at dose rates of 5.0 to 7.7 mg/kg body weight [7].

Biological context of ZOLAZEPAM

• Thermoregulation in Telazol (CI-744)-anesthetized rhesus monkey (Macaca mulatta) [8].
• In conclusion, xylazine-Telazol combination produced better muscle relaxation and longer duration of anesthesia than Telazol alone [9].
• There were no differences in heart rates (P = 0.36), blood pressures (P = 0.32), respiratory rates (P = 0.91), and rectal temperatures (P = 0.62) between the two TEL doses [10].
• Pharmacokinetics and tissue residues of Telazol in free-ranging polar bears [11].
• In 1986, 213 polar bears (Ursus maritimus) were immobilized with Telazol on the sea ice of the eastern Beaufort Sea during April and May, and 106 along the western coast of Hudson Bay near Churchill, Manitoba (Canada) in September [12].

Anatomical context of ZOLAZEPAM

• CONCLUSIONS: Photoreceptor and postreceptoral responses recorded under Nembutal and Telazol anesthesia differ significantly [13].

Associations of ZOLAZEPAM with other chemical compounds

• A combination of equal parts by weight of tiletamine hyrochloride and zolazepam hydrochloride was evaluated clinically in 12 adult male ferrets [14].
• Although recovery periods may be prolonged, higher doses of Telazol and xylazine should be safe based on data from domestic pigs [15].
• Immobilization of giant Chacoan peccaries (Catagonus wagneri) with a tiletamine hydrochloride/zolazepam hydrochloride combination [16].

Analytical, diagnostic and therapeutic context of ZOLAZEPAM

• Densitometric quantitation of immunoblots revealed that the hepatic CYP2B content was elevated by approximately 15-, 22-, and 25-fold, and the hepatic CYP3A content was increased by 2-, 2-, and 8-fold after treatment with zolazepam, Telazol, and PB, respectively [4].
• Telazol doses of 2.1 to 6.5 mg/kg resulted in a mean (+/- SD) induction time of 2.3 +/- 0.9 min and a mean (+/- SD) immobilization time of 82.2 +/- 28.6 min [17].
• Our results indicate that Telazol does not produce analgesia in rabbits and is nephrotoxic at both 32 and 64 mg/kg [18].

References