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Chemical Compound Review

Parvaquona     3-cyclohexyl-4-hydroxy- naphthalene-1,2-dione

Synonyms: Parvaquone, Parvaquonum, Wellcome 993C, NSC-278, NSC278, ...
 
 
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Disease relevance of NSC 278

 

High impact information on NSC 278

 

Chemical compound and disease context of NSC 278

 

Anatomical context of NSC 278

  • Elimination of schizonts with the anti-theilerial drug, parvaquone, resulted in reduced antigenicity of the membrane fraction as detected by both the T cell clones and the schizont-specific monoclonal antibody [10].
  • Schizont-infected cell lines derived by in vitro infection of bovine T cell clones with the Muguga isolate of Theileria parva were treated for 72 hr with the theileriacidal drug, parvaquone, at a concentration of 10 micrograms/ml [7].
  • Parvaquone was tested in cattle infected with Theileria annulata when they were presented at clinics in the vicinity of Baghdad. Out of over 200 cases presented with suspected theileriosis between July 1984 and July 1985, the drug was used in 45 cases where theileriosis was confirmed by microscopic examination of blood and lymph node biopsy smears [11].
 

Associations of NSC 278 with other chemical compounds

  • A high performance liquid chromatographic (HPLC) method for the determination of the antitheilerial drugs parvaquone and buparvaquone in plasma was developed [12].
  • Two groups of five cattle were immunised with a field isolate of Theileria parva as stabilate and simultaneously treated with long acting oxytetracycline or parvaquone in early clinical disease [13].
 

Gene context of NSC 278

 

Analytical, diagnostic and therapeutic context of NSC 278

References

  1. Treatment of theileriosis with parvaquone in Zambia. Musisi, F.L., Morgan, D.W., Schels, H.F. Vet. Rec. (1985) [Pubmed]
  2. Imidocarb and parvaquone in the treatment of piroplasmosis (Babesia equi) in equids. Kuttler, K.L., Zaugg, J.L., Gipson, C.A. Am. J. Vet. Res. (1987) [Pubmed]
  3. Chemotherapy of East Coast fever: the long term weight changes, carrier state and disease manifestations of parvaquone treated cattle. Dolan, T.T. J. Comp. Pathol. (1986) [Pubmed]
  4. Treatment of Theileria annulata infection in calves with parvaquone. McHardy, N., Morgan, D.W. Res. Vet. Sci. (1985) [Pubmed]
  5. Comparative studies of the efficacy of parvaquone and parvaquone-plus-frusemide in the treatment of Theileria parva infection (East Coast fever) in cattle. Mbwambo, H.A., Sudi, F.F., Mkonyi, P.A., Mfinanga, J.M., Mella, E.S., Ngovi, C.J. Vet. Parasitol. (2002) [Pubmed]
  6. Treatment of experimentally induced cytauxzoonosis in cats with parvaquone and buparvaquone. Motzel, S.L., Wagner, J.E. Vet. Parasitol. (1990) [Pubmed]
  7. Theileria parva: reappearance of schizonts in infected lymphoblastoid cells treated with parvaquone is dependent on interleukin 2-like growth factors. Brown, W.C., Shaw, M.K., Conrad, P.A., Dolan, T.T. Exp. Parasitol. (1989) [Pubmed]
  8. Chemotherapy of bovine tropical theileriosis: Theileria annulata infection. Gill, B.S., Bhattacharyulu, Y., Singh, A., Kaur, D. Res. Vet. Sci. (1984) [Pubmed]
  9. Treatment of East Coast fever of cattle with a combination of parvaquone and frusemide. Musoke, R.A., Tweyongyere, R., Bizimenyera, E., Waiswa, C., Mugisha, A., Biryomumaisho, S., McHardy, N. Tropical animal health and production. (2004) [Pubmed]
  10. Theileria parva: bovine helper T cell clones specific for both infected lymphocytes and schizont membrane antigens. Brown, W.C., Sugimoto, C., Grab, D.J. Exp. Parasitol. (1989) [Pubmed]
  11. Efficacy of parvaquone in the treatment of naturally occurring theileriosis in cattle in Iraq. Hawa, N., Rae, D.G., Younis, S., Mahadi, W., Ibrahim, R., al-Wahab, W. Tropical animal health and production. (1988) [Pubmed]
  12. Parvaquone and buparvaquone: HPLC analysis and comparative pharmacokinetics in cattle. Kinabo, L.D., Bogan, J.A. Acta Trop. (1988) [Pubmed]
  13. Comparison of long acting oxytetracycline and parvaquone in immunisation against East Coast fever by infection and treatment. Dolan, T.T., Linyonyi, A., Mbogo, S.K., Young, A.S. Res. Vet. Sci. (1984) [Pubmed]
  14. Chemotherapy of East Coast fever: parvaquone treatment of clinical disease induced by isolates of Theileria parva. Dolan, T.T., Young, A.S., Leitch, B.L., Stagg, D.A. Vet. Parasitol. (1984) [Pubmed]
  15. Relationships between Cytauxzoon felis and African piroplasmids. Uilenberg, G., Franssen, F.F., Perié, N.M. Vet. Parasitol. (1987) [Pubmed]
 
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